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Publikováno v:
Molecular Biology Reports. 49:531-537
Signal recognition particle (SRP) promotes co-translational translocation of the proteins through or into the endoplasmic reticulum membrane and it also has elongation arrest function. SRP9 is one of the six protein subunits of SRP and functions in e
Publikováno v:
Molecular Biology Reports. 48:7147-7152
The promoter region is a key element of gene expression regulation. In mammals, most of the genes present, at the level of their promoter, a large number of islands CpG. Age also is seen as another factor for developing breast cell cancer reaching th
Autor:
Kejia Hu, Lei Deng, Chuanxu Luo, Chengshi Wang, Rulla M. Tamimi, Donghao Lu, Fang Fang, Unnur Valdimarsdóttir, Katja Fall
Publikováno v:
Br J Cancer
BACKGROUND: To assess the risk of cardiovascular mortality among cancer survivors who developed breast cancer as a second malignancy (BCa-2) compared with patients with first primary breast cancer (BCa-1) and the general population. METHODS: Using th
Autor:
Janice Lu, Pushpinder Kaur, Alexander Ring, Julie E. Lang, Anthony R. Colombo, Irene Kang, Tania B. Porras
Publikováno v:
Br J Cancer
Background Individualising treatment in breast cancer requires effective predictive biomarkers. While relatively few genomic aberrations are clinically relevant, there is a need for characterising patients across different subtypes to identify action
Autor:
Shuo Li, Xiaoqing Shi, Xiaofeng Huang, Lu Xu, Yinggang Xu, Zhu Qiannan, Weiwei Zhang, Rui Chen, Yan Li, Jue Wang, Xiaoming Zha
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:3495-3501
Purpose Studies show that axillary surgery can be potentially omitted in certain breast cancer patients who achieve breast pathologic complete response (pCR) after neoadjuvant systemic therapy (NST). However, potential differences between the ypT0 an
Autor:
Andreas Schneeweiss, Wolfgang Wick, Georg Martin Haag, Joachim Wiskemann, Jana Müller, Karen Steindorf, Markus Weiler
Publikováno v:
British Journal of Cancer
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common, unpleasant and usually long-lasting side effect of neurotoxic chemotherapeutic agents. This study aimed to investigate the preventive potential of sensorimotor- (SMT) and resis
Autor:
Joanna Streb, Katarzyna Ewa Tyrak, Krzysztof Okoń, Joanna Szpor, Diana Hodorowicz-Zaniewska, Anna Glajcar, Agnieszka Łazarczyk
Publikováno v:
Virchows Archiv
Luminal A breast cancers are generally associated with low metastatic potential and good prognosis. However, there is a proportion of patients, who present with metastases in lymph nodes. The aim of our study was to determine the association between
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:533-542
Genetic variation in the activation of the prodrug cyclophosphamide (CP) by cytochrome P450 (CYP) enzymes has been shown to influence outcomes. However, CYP are also subject to phenoconversion due to either the effects of comedications or cancer asso
Autor:
Ehsan Sohrabi, Mansoor Khaledi, Hamed Afkhami, Javad Fathi, Masoumeh Moslemi, Ali Zekri, Ehsan Rezaie, Nahid Nafissi
Publikováno v:
Genes & Genomics. 43:1065-1077
Background: Breast cancer (BC) is a common malignancy with a high mortality rate. Malignant cell transformation is associated with metabolic changes. One group pf proteins that are affected are the monocarboxylate transporters (MCTs-SLC16A). The MCTs
Publikováno v:
Br J Cancer
Background We sought to estimate the annual risk and 25-year cumulative risk of contralateral breast cancer among women with stage 0-III unilateral breast cancer. Methods We identified 812,851 women with unilateral breast cancer diagnosed between 199