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Autor:
Yuuta Yamamoto, Takuya Matsuda, Akihiro Kimura, Nao Shimizu, Shozo Nishida, Shuji Genno, Masanobu Tsubaki, Tomoya Takeda
Publikováno v:
Clinical and Experimental Medicine. 22:221-228
Non-small cell lung cancer (NSCLC) is a highly aggressive cancer with one of the most prevalent malignant tumors. Metastasis in NSCLC is the major cause of treatment failure and cancer-related deaths. Yes-associated protein (YAP) is a transcriptional
Autor:
Farhad Pouremamali, Yousef Faridvand, Pirouz Pourmohammad, Hamid Reza Nejabati, Saba Hajazimian, Mahsa Ghaffari-Novin, Nazila Fathi Maroufi, Alireza Isazadeh, Mohsen Rashidi, Vahid Vahedian, Mohammad Nouri
Publikováno v:
Biochemical Genetics. 60:1-23
miRNAs are evolutionarily conserved non-coding ribonucleic acids with a length of between 19 and 25 nucleotides. Because of their ability to regulate gene expression, miRNAs have an important function in the controlling of various biological processe
Autor:
Jun Hu, Chun-Wa Wong, Xincheng Liu, Lin Ziqing, Jia Dan, Jing Cai, Lebin Liang, Max Sander, Deli Song, Wenbo Zhu, Jingyi Tan, Jiayu Zhang, Ying Liu, Xiaozhi Yang, Guangmei Yan, Yuwei Zhou, Yuan Lin, Jiankai Liang, Yanming Zhang
Publikováno v:
Oncogene. 40:4783-4795
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among breast tumors and remains a challenge even for the most current therapeutic regimes. Here, we demonstrate that oncolytic alphavirus M1 effectively kills both TNBC and
Publikováno v:
Oncogene. 40:4625-4651
This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multipl
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 394:1949-1961
Breast cancer is the most common malignancy in women worldwide. Strategies for cancer chemotherapy commonly require the use of combination therapy for better outcomes of results. The present work is aimed to evaluate the potential of naringenin and m
Autor:
Alexey Manikhas, Hans Friedrich Koch, Charuwan Akewanlop, Kakhaber Baramidze, Sirshendu Roy, Gopichand Mamillapalli, Ashwani Marwah, Virote Sriuranpong, Eduardo Yanez Ruiz, Miguel Hernandez-Bronchud, Unmesh Gopalakrishnan, Maria Luisa T. Abesamis-Tiambeng, Guzel Mukhametshina, Abhijit Barve, Joseph D. Parra, Adolfo Fuentes-Alburo, Ihor Vynnychenko, Sarika Deodhar, Gia Nemsadze, Igor Bondarenko, Eduardo J. Pennella, Cornelius F. Waller, Hope S. Rugo, Jay Herson, Subramanian Loganathan
Publikováno v:
Breast Cancer Research and Treatment
Breast cancer research and treatment, vol 188, iss 2
Breast cancer research and treatment, vol 188, iss 2
Purpose The phase 3 HERITAGE trial demonstrated that the biosimilar trastuzumab-dkst is well tolerated with similar efficacy (measured by overall response rate [ORR] and progression-free survival [PFS]) compared with originator trastuzumab combined w
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:533-542
Genetic variation in the activation of the prodrug cyclophosphamide (CP) by cytochrome P450 (CYP) enzymes has been shown to influence outcomes. However, CYP are also subject to phenoconversion due to either the effects of comedications or cancer asso
Autor:
Thella Revanth, Sreejita Saha, Deboshruti Chakraborty, Sharada Rai, Nitin Joseph, Flora D. Lobo, Gauri Badoni, Kshitiz Singhal
Publikováno v:
Indian J Surg Oncol
Paediatric cancers are gradually on the rise in India. Its proportion among children aged
Autor:
Kang Sun, Jing Zhang, Mingkun Yan, Baiqing Li, Shuo Lian, Jin Wu, Jun Xia, Jia Ma, Wenjing Zhou, Chaoqun Lian
Publikováno v:
Frontiers of Medicine. 15:922-932
Aberrant de novo lipid synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need. In this study, we
Autor:
Lama Hamadneh, Bashaer Abu-Irmaileh, May Al-Majawleh, Tariq Al-Qirim, Yazun Jarrar, Yasser Bustanji
Publikováno v:
Molecular and Cellular Biochemistry. 476:3647-3654
Breast cancer is one of the significant causes of death among women diagnosed with cancer worldwide. Even though several chemotherapy combinations are still the primary treatment of breast cancer, unsuccessful treatments, and poor prognostic outcomes