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Publikováno v:
British Journal of Cancer
Background Cancer stem cells (CSCs) are related to the patient’s prognosis, recurrence and therapy resistance in oesophageal squamous cell carcinoma (ESCC). Although increasing evidence suggests that aspirin (acetylsalicylic acid, ASA) could lower
Autor:
Agnieszka Paradowska-Gorycka, Ewa Walczuk, Katarzyna Romanowska-Próchnicka, Malgorzata Jaronczyk, L N Sivitskaya, Tomasz Wysocki, Jakub Lach, Anna Wajda, Barbara Stypinska, Danat Yermakovich
Publikováno v:
The Pharmacogenomics Journal
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX metabolis
Autor:
Richard M. Weinshilboum, David Goldman, Jennifer R. Geske, Victor M. Karpyak, Sofia Pozsonyiova, Colin A. Hodgkinson, Lea Zillich, Ada Man-Choi Ho, Ray Anton, Colin L. Colby, Ming Fen Ho, Brandon J. Coombes, Anthony Batzler, Stephanie S. O'Malley, Josef Frank, Joanna M. Biernacka, M. Rietschel, Karl Mann, Falk Kiefer, Michelle K. Skime
Publikováno v:
Neuropsychopharmacology
Naltrexone can aid in reducing alcohol consumption, while acamprosate supports abstinence; however, not all patients with alcohol use disorder (AUD) benefit from these treatments. Here we present the first genome-wide association study of AUD treatme
Autor:
Parminder Singh, Irbaz Bin Riaz, Cassandra N. Moore, Heidi E. Kosiorek, Renee K. Sharpsten, Andrea McNatty, Glenn A. Stewart, Steven R. Hwang, Alan H. Bryce, Thai H. Ho, Jan B. Egan, Miguel Gonzalez Velez, Brian A. Costello
Publikováno v:
Prostate Cancer and Prostatic Diseases. 25:479-483
Background Altered tumor suppressor genes (TSG-alt) in prostate cancer are associated with worse outcomes. The prognostic value of TSG-alt in metastatic, hormone-sensitive prostate cancer (M1-HSPC) is unknown. We evaluated the effects of TSG-alt on o
Autor:
Yi-long Wang, Ben-qing Wu, Weizhong Gu, Pei-chun Chen, Zhengyan Zhao, Meng-ying Zhu, Xiao-qiang Hao, Jinhu Wang, Chu-di Zhang, Yao Lv, Jin-gan Lou, Dong-ming Zhou, Hongqiang Shen
Publikováno v:
Gastric Cancer
Background DDP-based chemotherapy is one of the first-line treatment in GC. However, the therapeutic efficacy of DDP is limited due to side effects. Therefore, it is of great significance to develop novel adjuvants to synergize with DDP. We had demon
Autor:
In Jeoung Baek, Dae Won Jun, Brian Raught, Eun-Jung Jin, Chang Yeob Han, Jinsoo Song, Peter K. Kim, Sujeong Park, Kyu Yun Jang
Publikováno v:
Experimental & Molecular Medicine
In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12−/−), the major acyl-C
Autor:
Sumana Chakravarty, Eric R. James, Stephen L. Hoffman, Lei K. Ding, Jillian Neal, Charles Wyatt, Sahand Kalhori, Anita Manoj, Alemush Imeru, Omely Marte-Salcedo, Sangeeta N. Bhatia, Hope Decederfelt, David M. Cook, Agnes Mwakingwe-Omari, Martha Nason, Jen C. C. Hume, Sara A. Healy, Aarti Kolluri, Natasha Kc, Ijeoma Ikpeama, B. Kim Lee Sim, Peter F. Billingsley, Sean C. Murphy, L. W. Preston Church, Jihyun E. Jeon, Sandra March, Grace K. Lee, Irfan Zaidi, Jacob Raiten, Junhui Duan, Anusha Gunasekera, Thomas L. Richie, Tooba Murshedkar, Jacquelyn Lane, Patrick E. Duffy, Charles Anderson
Publikováno v:
Nature. 595:289-294
The global decline in malaria has stalled1, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination (CVac), for which aseptic, purified, cryopreserved, infectious Plasmod
Autor:
Melissa Sorosina, Ferdinando Clarelli, P. Provero, G. Comi, F. Martinelli Boneschi, Laura Ferrè, Federica Esposito, Massimo Filippi, Elisabetta Mascia, Linda Ottoboni, Giacomo Sferruzza, Silvia Santoro, Lucia Moiola, Vittorio Martinelli
Publikováno v:
Molecular Neurobiology. 58:4816-4827
Fingolimod (FTY), a second-line oral drug approved for relapsing remitting Multiple Sclerosis (RRMS) acts in preventing lymphocyte migration outside lymph nodes; moreover, several lines of evidence suggest that it also inhibits myeloid cell activatio
Autor:
Hiroki Ishihara, Takashi Ikeda, Hiroaki Shimmura, Toshio Takagi, Hideki Ishida, Kazunari Tanabe, Junpei Iizuka, Kazutaka Nakamura, Hidekazu Tachibana, Kazuhiko Yoshida, Hirohito Kobayashi, Hironori Fukuda, Yasunobu Hashimoto, Tsunenori Kondo, Yuki Nemoto
Publikováno v:
Targeted Oncology. 16:493-502
It remains unclear how early treatment interruption of nivolumab plus ipilimumab due to immune-related adverse events affects the outcome of previously untreated metastatic renal cell carcinoma (mRCC). To investigate the prognostic impact of the earl
Autor:
Kathrine Grell, Lisa Lyngsie Hjalgrim, Anja Möricke, Jacob Nersting, Jaitri Joshi, Bruce Bostrom, Petter Quist-Paulsen, Kim Dalhoff, Bendik Lund, Kristi Lepik, Anthony V. Moorman, Goda Vaitkevičienė, Kjeld Schmiegelow, Daniel Murdy, Jukka Kanerva, Olafur G. Jonsson, Linea Natalie Toksvang, Bodil Als-Nielsen, Martin Zimmermann, Stine Nygaard Nielsen, Ajay Vora, Matilda Degn, Laimonas Griskevicius, Jonas Abrahamsson
Publikováno v:
Leukemia. 36:33-41
Methotrexate/6-mercaptopurine maintenance therapy improves acute lymphoblastic leukemia (ALL) outcome. Cytotoxicity is mediated by DNA incorporation of thioguanine nucleotides (DNA-TG). We investigated the association of DNA-TG to relapse risk in 1 9