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Publikováno v:
British Journal of Cancer
Background Cancer stem cells (CSCs) are related to the patient’s prognosis, recurrence and therapy resistance in oesophageal squamous cell carcinoma (ESCC). Although increasing evidence suggests that aspirin (acetylsalicylic acid, ASA) could lower
Autor:
Agnieszka Paradowska-Gorycka, Ewa Walczuk, Katarzyna Romanowska-Próchnicka, Malgorzata Jaronczyk, L N Sivitskaya, Tomasz Wysocki, Jakub Lach, Anna Wajda, Barbara Stypinska, Danat Yermakovich
Publikováno v:
The Pharmacogenomics Journal
Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis. Nevertheless, MTX resistance is quite a common issue in clinical practice. There are some premises that aryl hydrocarbon receptor (AhR) gene battery may take part in MTX metabolis
Autor:
Parminder Singh, Irbaz Bin Riaz, Cassandra N. Moore, Heidi E. Kosiorek, Renee K. Sharpsten, Andrea McNatty, Glenn A. Stewart, Steven R. Hwang, Alan H. Bryce, Thai H. Ho, Jan B. Egan, Miguel Gonzalez Velez, Brian A. Costello
Publikováno v:
Prostate Cancer and Prostatic Diseases. 25:479-483
Background Altered tumor suppressor genes (TSG-alt) in prostate cancer are associated with worse outcomes. The prognostic value of TSG-alt in metastatic, hormone-sensitive prostate cancer (M1-HSPC) is unknown. We evaluated the effects of TSG-alt on o
Autor:
Asmaa M A Bayoumi, Sayed Shehata, Marwa M.M. Refaie, Walaa Yehia Abdelzaher, Nashwa Fathy Gamal El-Tahawy
Publikováno v:
Cardiovascular Drugs and Therapy. 36:817-827
The cardiotoxicity of anticancer drugs such as 5-fluorouracil (5FU) is a major complication that challenges their clinical usefulness. Thus there is a critical need to find new protective drugs to defend against these harmful side effects. Up to now,
Autor:
Yue Wang, Hong-feng Jiang, Hai-ming Dang, Meng-ru Liu, Xin-yan Liu, Yang Yu, Jiang Xie, Xiao-jun Zhan, Hui-na Zhang, Xiao-fan Wu
Publikováno v:
Cardiovascular Drugs and Therapy. 36:805-815
It has been established that obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. Chronic intermittent hypoxia (CIH) activates sympathoadrenal system and upregulates β3 adrenergic receptor (β3 AR). However, the effect of
Autor:
Tamires Flauzino, Edna Maria Vissoci Reiche, Maisa Rocha Nagao, Marcell Alysson Batisti Lozovoy, Maria Caroline Martins de Araújo, Daniela Frizon Alfieri, Andréa Name Colado Simão, Leonardo Bodner de Freitas, José Wander Breganó, Emanuelle Roberto Trevisani, Michael Maes, Jair Roberto Gelinski, Ana Lucia Cruz Fürstenberger Lehmann, Francisco Spessatto Pesente, Marcio Francisco Lehmann
Publikováno v:
Clinical and Experimental Medicine. 22:111-123
Some clinical, imaging, and laboratory biomarkers have been identified as predictors of prognosis of acute ischemic stroke (IS). The aim of this study was to evaluate the prognostic validity of a combination of clinical, imaging, and laboratory bioma
Publikováno v:
Archives of Toxicology. 95:2895-2940
Cathinone, the main psychoactive compound found in the plant Catha edulis Forsk. (khat), is a β-keto analogue of amphetamine, sharing not only the phenethylamine structure, but also the amphetamine-like stimulant effects. Synthetic cathinones are de
Autor:
M V Putilina, D. V. Grishin
Publikováno v:
Neuroscience and Behavioral Physiology
The SARS-CoV-2 (COVID-19) pandemic has attracted attention to the challenge of neuroinflammation as an unavoidable component of viral infections. Acute neuroinflammatory responses include activation of resident tissue macrophages in the CNS followed
Publikováno v:
Inflammopharmacology. 29:825-839
The effects of Chrysophyllum albidum fruit pulp on haemodynamic parameters, pro-inflammatory markers, antioxidant parameters and critical biomolecules associated with hypertension in vivo were determined. Feeding with supplemented diet with pulp redu
Autor:
Salwa Fayez, Basma Emad Aboulhoda, Laila A. Rashed, Sahar M. Abd Elwahab, Zeinab A. Nour, Asmaa Fathi Galal, Ola Ahmed Heikal, Shimaa Saad El-Din
Publikováno v:
Metabolic Brain Disease. 36:1903-1915
Alzheimer's Disease (AD), the most prevalent neurodegenerative disorder among elderly people, is ordinarily associated with progressive cognitive decline. Peroxisome proliferator-activated receptors-gamma (PPAR-γ) agonists can be targeted as a benef