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of 217
pro vyhledávání: ''
Autor:
Henghui Zhang, Wei Zhou, Chao Wu, Ruyan Xie, Xianchao Guo, Jun Ji, Lei Zhang, Chenhong Peng, Fei Yuan, Ying Yang, Chao Wang, Min Shi, Jun Zhang
Publikováno v:
Cancer Immunology, Immunotherapy
Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-yea
Autor:
Mathijs A. Sanders, Mark van Duin, Pieter Sonneveld, Cyrus Khandanpour, Sabrin Tahri, Zoltán Kellermayer, Jessica Vermeulen, Davine Hofste op Bruinink, Pieter C. van de Woestijne, P. Koen Bos, Madelon de Jong, Remco Hoogenboezem, Annemiek Broijl, Tom Cupedo, Philippe Moreau, Natalie Papazian
Publikováno v:
Nature Immunology, 22(6), 769-780. Nature Publishing Group
Progression and persistence of malignancies are influenced by the local tumor microenvironment, and future eradication of currently incurable tumors will, in part, hinge on our understanding of malignant cell biology in the context of their nourishin
Autor:
Salvatore Siena, Emilia Maria Cristina Mazza, Giulia Della Chiara, Chiara Godano, Nicola Zucchini, Valeria Ranzani, Stefania Oliveto, Paola Gruarin, Jens Geginat, Roberto Bosotti, Claudia D'Oria, Elena Carelli, Pierluigi Novellis, Saveria Mazzara, Ylenia Silvestri, Marco Passaro, Alessio Amatu, Marco Alloisio, Antonio Lanzavecchia, Stefano Biffo, Giorgia Alvisi, Federica Gervasoni, Maria Lucia Sarnicola, N. Mariani, Alberto Bardelli, Ramona Bason, Jolanda Brummelman, Mariangela Lorenzo, Giulia Veronesi, Emanuela Bonoldi, Massimiliano Pagani, Daniele Prati, Enrico Opocher, Lorenzo Drufuca, Martina Martinovic, Andrea Sartore-Bianchi, Sergio Abrignani, Alessandro Giani, Marco De Simone, Enrico Lugli, Chiara Cordiglieri, Serena Curti, Grazisa Rossetti, Valeria Bevilacqua, Andrea Pisani Ceretti, Raoul J. P. Bonnal
Publikováno v:
Nature Immunology, 22, 735-745
Nature Immunology, 22, 6, pp. 735-745
Nature Immunology, 22, 6, pp. 735-745
Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and metastatic colorectal cancer and non-small-cell lung cancer are highly e
Publikováno v:
Inflammation. 44:1803-1814
Rheumatoid arthritis (RA) remains the most common inflammatory arthritis and a major cause of disability. This study investigated the mechanism of MLL3 in fibroblast-like synoviocyte (FLS) apoptosis and inflammatory factor secretion in RA. Expression
Autor:
Karam Khaddour, Sangeeta Khanna, Michael Ansstas, Ishaan Jakhar, Sonika Dahiya, Laurin Council, George Ansstas
Publikováno v:
Cancer Immunology, Immunotherapy
Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome that involves the production of autoantibodies which can cross-react with retinal epitopes leading to visual symptoms. Autoantibodies can target intracellular proteins, and only a few
Publikováno v:
Genes & Immunity. 21:380-389
Killer cell immunoglobulin-like receptors (KIR) consists of activating and inhibitory genes are essential for natural killer cell education. To determine the association of KIRs with susceptibility to invasive Breast cancer (BC), genotyping of 16 KIR
Autor:
Annamaria Offidani, Anna Campanati, Mariangela Di Vincenzo, Monia Orciani, Giulia Radi, Federico Diotallevi, Miriam Caffarini, Guendalina Lucarini
Publikováno v:
Inflammation Research. 70:79-87
Psoriasis cellular hallmarks, such as the imbalance between Th1/Th17 and Th2 cytokines and the dysregulated expression of vascular endothelial growth factor (VEGF), inducible nitric oxide synthase, (iNOS) and indoleamine 2,3-dioxygenase (IDO), are al
Autor:
Enrico Giarnieri, Adriana Bonifacino, Daniele Greco, Marshall E. Kadin, Fabio Santanelli di Pompeo, Alessandro Gulino, Luigi Aurisicchio, Arianna Di Napoli, John Morgan, Giorgia Scafetta, Rita Mancini, Francesca Ascenzi
Publikováno v:
Cancer Immunology, Immunotherapy
Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is an uncommon peripheral T cell lymphoma usually presenting as a delayed peri-implant effusion. Chronic inflammation elicited by the implant has been implicated in its pathogenesis.
Autor:
Jialu Li, Conglin Shen
Publikováno v:
Inflammation. 44:194-205
Sepsis is recognized as the acute systemic inflammatory response to severe infection. It is main cause of multiple organ system dysfunction and even organ failure. Long non-coding RNA X inactivate-specific transcript (XIST) is implicated in multiple
Autor:
Tomoya Muto, Zartash Gul, Molly A. Smith, Kwangmin Choi, Yi Zheng, Daniel T. Starczynowski, Guillermo Garcia-Manero, Callum S. Walker, Kathleen Hueneman, Averil Ma
Publikováno v:
Nat Immunol
Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and progenitor cells (HSPCs), the mechanisms responsible for the competitive a