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Autor:
Jiani Hu, Khanh T. Do, Geoffrey I. Shapiro, Emily M. Thrash, Claire Manuszak, Anita Giobbie-Hurder, Allison Powers, Sarah Kelland, Adrienne de Jonge, Mariano Severgnini
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2991-3000
Checkpoint kinase 1 (CHK1) has dual roles in both the DNA damage response and in the innate immune response to genotoxic stress. The combination of CHK1 inhibition and immune checkpoint blockade has the potential to enhance anti-tumoral T-cell activa