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Publikováno v:
Scientific Reports. 13
Deficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the locus coeruleus (LC)
Publikováno v:
Mol Neurobiol
Sex differences in opioid analgesia occur in rodents and humans, and could be due to differences in drug and metabolite levels. Thus, we investigated the sex and cycle differences in analgesia (nociception) from oxycodone in rats and related these to
Autor:
Paola Perrotta, Margreet R. de Vries, Pieter-Jan Guns, Bart Peeters, Wim Martinet, Guido R.Y. De Meyer, Paul H.A. Quax
Publikováno v:
Angiogenesis
Angiogenesis, 25, 129-143. SPRINGER
Angiogenesis, 25, 129-143. SPRINGER
Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP) angiogenesis, which promotes atherogenesis and formation of unstable plaques. Graft neovessels are main
Autor:
Gustavo Turecki, Saumeh Saeedi, Jane A. Foster, Sidney H. Kennedy, Laura M. Fiori, Corina Nagy, Marina Wakid, Jean-François Théroux, Jennie Yang, Naguib Mechawar, Susan Rotzinger, Pascal Ibrahim
Publikováno v:
Molecular Psychiatry. 26:7417-7424
Previous work has demonstrated that microRNAs (miRNAs) change as a function of antidepressant treatment (ADT) response. However, it is unclear how representative these peripherally detected miRNA changes are to those occurring in the brain. This stud
Publikováno v:
Psychopharmacology (Berl)
Drugs of abuse including cannabis and inhalants impair risk/reward decision making. Cannabis use is often concurrent with inhalant intoxication; yet, preclinical studies investigating the role of endocannabinoids in inhalant misuse are limited. To ad
Autor:
Emmanuel Ampofo, Maximilian M Menger, Matthias W. Laschke, Michael D. Menger, Leticia Prates Roma, Lisa Nalbach
Publikováno v:
Acta Diabetologica
Aims The exposure of isolated pancreatic islets to pro-angiogenic factors prior to their transplantation represents a promising strategy to accelerate the revascularization of the grafts. It has been shown that erythropoietin (EPO), a glycoprotein re
Publikováno v:
Journal of Endocrinological Investigation
Aims Metformin, rosiglitazone and sulfonylureas enhance either insulin action or secretion and thus have been used extensively as early stage anti-diabetic medication, independently of the aetiology of the disease. When administered to newly diagnose
Autor:
Melissa Sorosina, Ferdinando Clarelli, P. Provero, G. Comi, F. Martinelli Boneschi, Laura Ferrè, Federica Esposito, Massimo Filippi, Elisabetta Mascia, Linda Ottoboni, Giacomo Sferruzza, Silvia Santoro, Lucia Moiola, Vittorio Martinelli
Publikováno v:
Molecular Neurobiology. 58:4816-4827
Fingolimod (FTY), a second-line oral drug approved for relapsing remitting Multiple Sclerosis (RRMS) acts in preventing lymphocyte migration outside lymph nodes; moreover, several lines of evidence suggest that it also inhibits myeloid cell activatio
Publikováno v:
Cardiovascular Toxicology. 21:800-807
The protective effect and mechanism of isoflurane on myocardial injury was investigated by constructing in vitro hypoxia/reoxygenation (HR) cell model. HR cell models were established in vitro and treated with isoflurane (ISO). qRT-PCR was used to de
Autor:
Li Han Sun, Chianfang G. Cherng, Ya Hsuan Chan, Yi Han Liao, Yu Han Huang, Ing Tiau B. Kuo, Hao Chen, Yi Chi Su, Lung Yu
Publikováno v:
Psychopharmacology. 238:2851-2865
This study was undertaken to assess the modulating effects of (1) pre-exposure to repeated social disruption and (2) group testing on writhing associated with visceral pain induced by intraperitoneal administration of acetic acid. Six consecutive day