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Prostaglandins (PGs) are signaling lipids derived from arachidonic acid (AA), which is metabolized by cyclooxygenase (COX)-1 or 2 and class-specific synthases to generate PGD2, PGE2, PGF2α, PGI2 (prostacyclin), and thromboxane A2. PGs signal through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de97163b5446cb8636d7351d5a6cd277
https://europepmc.org/articles/PMC5440348/
https://europepmc.org/articles/PMC5440348/
Autor:
Pinky Karim Syeda, Fumiaki Shono, Mitsuo Jisaka, Michael Nii N. Nartey, Mohammad Shahidur Rahman, Kohji Nishimura, Ferdous Khan, Mohammad Safiqul Islam, Kazushige Yokota
We have previously shown that cultured adipocytes have the ability to biosynthesize prostaglandin (PG) I2 called alternatively as prostacyclin during the maturation phase by the positive regulation of gene expression of PGI synthase and the prostanoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f2e29590e3d2c7d84b7faef36341b5
https://europepmc.org/articles/PMC5101312/
https://europepmc.org/articles/PMC5101312/
Publikováno v:
Dan Shen (Salvia miltiorrhiza) in Medicine ISBN: 9789401794626
The kidney is an important organ with multiple functions , primarily to excrete metabolic wastes through urination and to maintain the equilibrium of water, electrolytes, osmotic pressure, and acid–base balance in order to keep the internal environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdd86605796c78931170e2932d7c8bb
https://doi.org/10.1007/978-94-017-9463-3_9
https://doi.org/10.1007/978-94-017-9463-3_9
Autor:
Clary B. Clish, Karsten Gronert, Charles N. Serhan, Sean P. Colgan, Nan Chiang, Jessica Brannon
Publikováno v:
Advances in Prostaglandin and Leukotriene Research ISBN: 9789048158812
Many studies carried out in the past 25 years suggest that dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) have beneficial effects in human diseases [1,2]. These include antithrombotic, immunoregulatory, and anti-inflammatory responses releva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5907f2d2a57a5ae98e6fb8f64540b8
https://doi.org/10.1007/978-94-015-9721-0_9
https://doi.org/10.1007/978-94-015-9721-0_9
Publikováno v:
Side Effects of Anti-Inflammatory Drugs IV ISBN: 9789401062695
Misoprostol is currently marketed throughout the world for the prevention of non-steroidal anti-inflammatory drug-induced gastric/duodenal damage. Although safe and effective, intestinal side-effects, namely diarrhoea and cramping, can limit its use.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4da69b5033be52e86b2ac4bc58f9c3
https://doi.org/10.1007/978-94-011-5394-2_24
https://doi.org/10.1007/978-94-011-5394-2_24
Autor:
M. F. Browner
Publikováno v:
New Targets in Inflammation ISBN: 9789401062657
Non-steroid anti-inflammatory drugs (NSAIDs) exert their beneficial anti-inflammatory actions, as well as their undesirable gastro-intestinal effects, through inhibition of the enzyme prostaglandin H synthase1, also referred to as cyclooxygenase (COX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::471c708dab07cb059602d0bb56ebb9a5
https://doi.org/10.1007/978-94-011-5386-7_8
https://doi.org/10.1007/978-94-011-5386-7_8
Autor:
R. M. Botting, John R. Vane
Publikováno v:
Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors ISBN: 9789401090315
Inflammation is the response of living tissues to injury. It involves a complex battery of enzyme activation, mediator release, extravasation of fluid, cell migration, tissue breakdown and repair. This overview will concentrate on the actions of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09036f2f02d193323928a1de8bc4b7da
https://doi.org/10.1007/978-94-010-9029-2_1
https://doi.org/10.1007/978-94-010-9029-2_1
Autor:
Roberto Padovano, Francesco Cipollone, M. R. Panara, Giovanna Santini, Maria G. Sciulli, Paola Patrignani, M. di Giamberardino, Carlo Patrono, M. T. Rotondo
Publikováno v:
Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors ISBN: 9789401090315
The conversion of arachidonic acid to prostaglandin (PG) H2 is catalysed by PG-endoperoxide synthase (PGHS) which exhibits both cyclooxygenase (COX) and peroxidase activities1. PGH2 is further metabolized by other enzymes to various prostanoids (PGs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dac7f689a66bdb988e735a64189fa6b
https://doi.org/10.1007/978-94-010-9029-2_7
https://doi.org/10.1007/978-94-010-9029-2_7
Autor:
John Fawcett Wilson
Publikováno v:
The Immunoassay Kit Directory ISBN: 9780792388630
Prostaglandin F2α is a primary prostaglandin which can also be produced from prostaglandin E2 by the action of prostaglandin E9-ketoreductase in some tissue. It causes contraction of uterine smooth muscle at all stages of pregnancy and is used as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ca3899b5d32effede5a2131031bd8c1
https://doi.org/10.1007/978-94-011-0679-5_87
https://doi.org/10.1007/978-94-011-0679-5_87
Autor:
Helmut Sinzinger
Publikováno v:
Developments in Cardiovascular Medicine ISBN: 9789401055406
Endogenous prostaglandins have been shown to beneficially affect the haemostatic balance. Experimental as well as clinical pharmacological data confirmed this benefit for PGE1, PGI2 and the analogs iloprost and taprostene. Controlled trials are avail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc07f5912f473abbefa161060a1b9ed
https://doi.org/10.1007/978-94-011-3484-2_12
https://doi.org/10.1007/978-94-011-3484-2_12