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Autor:
Vigneshwaran Namasivayam, Christa E. Müller, Lukas Zappe, Ali El-Tayeb, Elisabetta De Filippo, Anke C. Schiedel
The G protein-coupled A2A adenosine receptor represents an important drug target. Crystal structures and modeling studies indicated that three disulfide bonds are formed between ECL1 and ECL2 (I, Cys71(2.69)-Cys159(45.43); II, Cys74(3.22)-Cys146(45.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44f798c433500bb62801e2b17df5700
https://europepmc.org/articles/PMC4854839/
https://europepmc.org/articles/PMC4854839/
Autor:
Bárbara S. Pinheiro, Rui O. Beleza, Cristina Lemos, Ricardo Gouveia Rodrigues, Attila Köfalvi, Joana Marques, Rodrigo A. Cunha, Daniel Rial
ATP consumption during intense neuronal activity leads to peaks of both extracellular adenosine levels and increased glucose uptake in the brain. Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83fd4bf9539b77142d6badb6a0f7e61
https://europepmc.org/articles/PMC4648789/
https://europepmc.org/articles/PMC4648789/
Publikováno v:
Purinergic Signalling
Latest results on the action of adenosine A(2A) receptor antagonists indicate their potential therapeutic usefulness in the treatment of Parkinson's disease. Basal ganglia possess high levels of adenosine A(2A) receptors, mainly on the external surfa
Autor:
Sarah E. Street, Nathaniel A. Sowa
Publikováno v:
Subcellular Biochemistry ISBN: 9789401771962
Chronic pain is one of the most debilitating and expensive diseases, yet current therapies are often insufficient in bringing about long-term relief. Further, many treatments for chronic pain also carry significant side effects. The molecule adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d2e2e52bde455e484b04936ff695fa
https://doi.org/10.1007/978-94-017-7197-9_13
https://doi.org/10.1007/978-94-017-7197-9_13
Stimulation of A2B adenosine receptors protects against trauma–hemorrhagic shock-induced lung injury
Autor:
Pal Pacher, Zoltan H. Nemeth, Alexey Trepakov, Balázs Csóka, Holger K. Eltzschig, György Haskó, Balázs Koscsó
Inflammation is responsible for secondary organ failure after trauma and hemorrhagic shock (T/HS). Adenosine, acting through four G protein-coupled cell surface receptors, A1, A2A, A2B, and A3, exerts a number of tissue protective and anti-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bed06f25cd9b253987a169f9728a1d
https://europepmc.org/articles/PMC3757139/
https://europepmc.org/articles/PMC3757139/
Autor:
José Luis Arteaga, Albino García-Sacristán, Paz Recio, Ana Martínez-Sáenz, Luis M. Orensanz, Dolores Prieto, Vítor S. Fernandes, Ana S. F. Ribeiro, Belén Climent, María Pilar Martínez, Medardo Hernández
Benign prostatic hypertrophy has been related with glandular ischemia processes and adenosine is a potent vasodilator agent. This study investigates the mechanisms underlying the adenosine-induced vasorelaxation in pig prostatic small arteries. Adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba44501a9754f4f380eeaf80763a1ce7
https://europepmc.org/articles/PMC3224642/
https://europepmc.org/articles/PMC3224642/
Autor:
Maryse Picher
Publikováno v:
Purinergic Regulation of Respiratory Diseases ISBN: 9789400712164
In the respiratory system, extracellular nucleotides and nucleosides serve as signaling molecules for a wide spectrum of biological functions regulating airway defenses against infection and toxic material. Their concentrations are controlled by a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732938b7f1b72fdb00b495fce671961b
https://doi.org/10.1007/978-94-007-1217-1_2
https://doi.org/10.1007/978-94-007-1217-1_2
Autor:
Karl-Norbert Klotz
Publikováno v:
A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics ISBN: 9789048131433
Adenosine is an important metabolite and a building block for many biologically relevant molecules. Most abundantly, it contributes the purine base adenine and a ribose to ATP which as an energy-providing compound occurs in millimolar concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80dfe7182bbabfd3973970fb586e377
https://doi.org/10.1007/978-90-481-3144-0_3
https://doi.org/10.1007/978-90-481-3144-0_3
Autor:
D. Scott McLeod, Gerard A. Lutty
Publikováno v:
Retinal and Choroidal Angiogenesis ISBN: 9781402067792
Adenosine is a ubiquitous molecule produced predominantly by catabolism of adenosine triphosphate. Levels of this nucleoside increase dramatically with ischemia and elevated tissue activity. Adenosine induces angiogenesis in tumors and wound healing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78778a066ba81fe15ae021d88c520d60
https://doi.org/10.1007/978-1-4020-6780-8_12
https://doi.org/10.1007/978-1-4020-6780-8_12
Publikováno v:
Delayed Preconditioning and Adaptive Cardioprotection ISBN: 9789401062312
Adenosine is a purine nucleoside that is produced by catabolism of adenosine triphosphate (ATP) by many different cell types. The cardiovascular actions of adenosine have been appreciated for many years (see reference 1 for review). It is known that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9803090df298a6af41b51f141c58914
https://doi.org/10.1007/978-94-011-5312-6_10
https://doi.org/10.1007/978-94-011-5312-6_10