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Publikováno v:
Purinergic Signal
Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play important roles in many diseases. Activation of P2 receptors (P2R) channels and subsequent membrane de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8e7567dfb641597ce56353cbe8def7
https://europepmc.org/articles/PMC8155138/
https://europepmc.org/articles/PMC8155138/
Publikováno v:
Purinergic Signal
Adenosine triphosphate (ATP) and adenosine are neurotransmitters and neuromodulators in the central nervous system. Astrocytes regulate extracellular concentration of purines via ATP release and its metabolisms via ecto-enzymes. The expression and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d3471e563d6d5aa817a755ae5e7498
https://europepmc.org/articles/PMC7855126/
https://europepmc.org/articles/PMC7855126/
Autor:
Vigneshwaran Namasivayam, Christa E. Müller, Lukas Zappe, Ali El-Tayeb, Elisabetta De Filippo, Anke C. Schiedel
The G protein-coupled A2A adenosine receptor represents an important drug target. Crystal structures and modeling studies indicated that three disulfide bonds are formed between ECL1 and ECL2 (I, Cys71(2.69)-Cys159(45.43); II, Cys74(3.22)-Cys146(45.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44f798c433500bb62801e2b17df5700
https://europepmc.org/articles/PMC4854839/
https://europepmc.org/articles/PMC4854839/
Autor:
Bárbara S. Pinheiro, Rui O. Beleza, Cristina Lemos, Ricardo Gouveia Rodrigues, Attila Köfalvi, Joana Marques, Rodrigo A. Cunha, Daniel Rial
ATP consumption during intense neuronal activity leads to peaks of both extracellular adenosine levels and increased glucose uptake in the brain. Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83fd4bf9539b77142d6badb6a0f7e61
https://europepmc.org/articles/PMC4648789/
https://europepmc.org/articles/PMC4648789/
Publikováno v:
Purinergic Signalling
Latest results on the action of adenosine A(2A) receptor antagonists indicate their potential therapeutic usefulness in the treatment of Parkinson's disease. Basal ganglia possess high levels of adenosine A(2A) receptors, mainly on the external surfa
Recruitment of oligodendrocyte precursor cells (OPCs) to the lesions is the most important event for remyelination after central nervous system (CNS) injury or in demyelinating diseases. However, the underlying molecular mechanism is not fully unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2f7c8b9429643e1618b4ca19c3d719
https://europepmc.org/articles/PMC4529846/
https://europepmc.org/articles/PMC4529846/
The pharmacokinetics of adenosine 5′-triphosphate (ATP) was investigated in a clinical trial that included 15 patients with advanced malignancies (solid tumors). ATP was administered by continuous intravenous infusions of 8 h once weekly for 8 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6601c229cfbc1ca64af7b793747b1a79
https://europepmc.org/articles/PMC4425716/
https://europepmc.org/articles/PMC4425716/
Autor:
Sarah E. Street, Nathaniel A. Sowa
Publikováno v:
Subcellular Biochemistry ISBN: 9789401771962
Chronic pain is one of the most debilitating and expensive diseases, yet current therapies are often insufficient in bringing about long-term relief. Further, many treatments for chronic pain also carry significant side effects. The molecule adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d2e2e52bde455e484b04936ff695fa
https://doi.org/10.1007/978-94-017-7197-9_13
https://doi.org/10.1007/978-94-017-7197-9_13
Autor:
Gregory Wynn, Geoffrey Burnstock
Publikováno v:
Purinergic Signalling
Evidence of a role for purinergic signalling in visceral afferents involving P2X(2), P2X(3) and P2Y(1) receptors exists, which appears to be important during inflammation. This study aimed to evaluate the degree of interaction between adenosine 5'-tr
Autor:
Roshni I. Patel, Catherine C. Redick, Rideout Janet L, José L. Boyer, Benjamin R. Yerxa, Sammy R. Shaver, Maryse Picher, William Pendergast, Edward G. Brown, James G. Douglass, Arthur C. Jones
Publikováno v:
Purinergic Signalling
Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine dinucleotides are found in most living cells and their actions are generally known. Unsymmetri