Zobrazeno 1 - 10
of 22
pro vyhledávání: ''
Autor:
Joern Pezoldt, Carolin Wiechers, Mangge Zou, Maria Litovchenko, Marjan Biocanin, Michael Beckstette, Katarzyna Sitnik, Martina Palatella, Guido van Mierlo, Wanze Chen, Vincent Gardeux, Stefan Floess, Maria Ebel, Julie Russeil, Panagiota Arampatzi, Ehsan Vafardanejad, Antoine-Emmanuel Saliba, Bart Deplancke, Jochen Huehn
Gut-draining mesenteric lymph nodes (LN) provide the framework to shape intestinal adaptive immune responses. Based on the transcriptional signatures established by our previous work, the composition and immunomodulatory function of LN stromal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b1596f6d0859d07ae304d91f41eaf2
https://doi.org/10.1038/s41467-022-34868-4
https://doi.org/10.1038/s41467-022-34868-4
Autor:
Kristina Zec, Roman Fischer, Irina A. Udalova, Tariq E. Khoyratty, Claire Pearson, Hayley L. Eames, Benedikt M. Kessler, Hannah Almuttaqi, Grigory Ryzhakov, Simon Travis, Samuel J. Bullers, Luke Jostins-Dean, Alastair L. Corbin, Sarah Bonham, Zhichao Ai, Dorothée L. Berthold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8cfb57ebeee917922ddd5935776e62
https://doi.org/10.1038/s41467-021-27038-5
https://doi.org/10.1038/s41467-021-27038-5
Autor:
Anders Moen, Jesper V. Olsen, Lisa Schroer, Ida A. Grønsberg, Niels Eijkelkamp, Albert Jeltsch, Takehiro Suzuki, Tadahiro Shimazu, Naoshi Dohmae, Erna Davydova, Mikiko Sodeoka, Valentina Siino, Mai Akakabe, Jędrzej Małecki, Pål Ø. Falnes, Michael A. McDonough, Takashi Umehara, Yoshihiro Sohtome, Magnus E. Jakobsson, Angela Ho, Rita Pinto, Masaki Kikuchi, Sara Weirich, Christopher J. Schofield, Yoichi Shinkai, Hanneke L.D.M. Willemen, Maren Kirstin Schuhmacher, Tongri Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8df554296bacb78fc88ad2f9d35057
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
Autor:
Rushika C. Wirasinha, Hong Ying Teh, Adam E. Handel, Stephen R. Daley, Benoit Roch, Saulius Žuklys, Stuart H. Orkin, Thomas Barthlott, Jean-Pierre de Villartay, Katrin Hafen, Georg A. Holländer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9e2439df69c3a497fbd82be6559f2d
https://doi.org/10.1038/s41467-021-24158-w
https://doi.org/10.1038/s41467-021-24158-w
Autor:
Yohei Kawana, Kei Takahashi, Keizo Kaneko, Shinjiro Kodama, Vladimir V. Kalinichenko, Tetsuya Yamada, Shojiro Sawada, Junta Imai, Yoichiro Asai, Akira Endo, Tomohito Izumi, Kenji Uno, Hideki Katagiri, Junpei Yamamoto, Junhong Gao, Masato Kohata, Hiroto Sugawara, Yasushi Ishigaki
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The liver possesses a high regenerative capacity. Liver regeneration is a compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that a vagus-macrophage-hepatocyte link regulates acute liver re
Autor:
Agostinho Carvalho, Johan Maertens, Marina Botto, Toine Mercier, Tilo Schorn, João F. Lacerda, Barbara Bottazzi, Katrien Lagrou, Ilaria Laface, António Campos, Sarah N. Mapelli, Francesca Petroni, Elena Magrini, Alberto Mantovani, Antonio Inforzato, John D. Lambris, Cristina Cunha, Raffaella Parente, Federico Colombo, Rémi Porte, Andrea Doni, Cecilia Garlanda
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b919d27fbbddc19312122cdb01b1a873
Autor:
Martina Schifferer, Ludovico Cantuti-Castelvetri, Susanne A. Schneider, Sabina Tahirovic, Andrew P. Lieberman, Jasmin König, Lina Dinkel, Silva Hećimović, Laura Sebastian Monasor, Tatiana Bremova-Ertl, Lea Vidatic, Alessio Colombo, Stephan A. Müller, Stefan F. Lichtenthaler, Michael Strupp, Mikael Simons
Publikováno v:
Nature communications
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f3dd22cdadfd9d9d515dc2698deab
http://fulir.irb.hr/6941/
http://fulir.irb.hr/6941/
Autor:
José Luis Trillo-Contreras, Pedro Gómez-Gálvez, Luis M. Escudero, Nieves Lara-Ureña, Andrea S. Bullones-Bolanos, Javier Vitorica, Miriam Echevarría, Rosana March-Díaz, Miguel Marchena, Jose Carlos Davila, Ana C. Sanchez-Hidalgo, Eloisa Herrera, Fernando de Castro, Jakob Körbelin, Antonia Gutierrez, Rocio González-Martínez, Alicia E. Rosales-Nieves, Raquel del Toro, Clara Ortega-de San Luis, Maria I. Alvarez-Vergara, Alberto Pascual, Pablo Vicente-Munuera, Manuel A. Sanchez-Garcia, Guiomar Rodriguez-Perinan, Martin Trepel, Francisco G. Scholl, Alberto Rábano, Javier Villadiego, Miguel Martin-Bornez, Beatriz Fernández-Gómez
Publikováno v:
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa049ed47a103e3d3ff4480d727c21b5
Autor:
Jianhua Li, Sebastian A. Leidel, Kenjiro Adachi, Karina Mildner, Rui Fan, Dagmar Zeuschner, Jie Wu, Yung Su Kim, Hans R. Schöler, Rui Chen, Styliani Galatidou, Guangming Wu, Ivan Bedzhov
Publikováno v:
Fan, Rui; Kim, Yung Su; Wu, Jie; Chen, Rui; Zeuschner, Dagmar; Mildner, Karina; Adachi, Kenjiro; Wu, Guangming; Galatidou, Styliani; Li, Jianhua; Schöler, Hans R.; Leidel, Sebastian A.; Bedzhov, Ivan (2020). Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nature Communications, 11(1) Springer Nature 10.1038/s41467-020-19353-0
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The epiblast, which provides the foundation of the future body, is actively reshaped during early embryogenesis, but the reshaping mechanisms are poorly understood. Here, using a 3D in vitro model of early epiblast development, we identify the canoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c7d65da8a54a7621a5f7a7ab5e2651
https://boris.unibe.ch/151555/1/s41467-020-19353-0.pdf
https://boris.unibe.ch/151555/1/s41467-020-19353-0.pdf
Autor:
Daniel Brigger, Rahel Ruppli, Pascal Guntern, Theodore S. Jardetzky, Alexander Eggel, Svetlana S. Tarchevskaya, Silke Kleinboelting, Noemi Zbären, Pascal Gasser, Christoph Heusser
Publikováno v:
Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f87e01b9a61768d0b922f9bc49897
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf