Zobrazeno 1 - 10
of 35
pro vyhledávání: ''
Autor:
Kristina Zec, Roman Fischer, Irina A. Udalova, Tariq E. Khoyratty, Claire Pearson, Hayley L. Eames, Benedikt M. Kessler, Hannah Almuttaqi, Grigory Ryzhakov, Simon Travis, Samuel J. Bullers, Luke Jostins-Dean, Alastair L. Corbin, Sarah Bonham, Zhichao Ai, Dorothée L. Berthold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8cfb57ebeee917922ddd5935776e62
https://doi.org/10.1038/s41467-021-27038-5
https://doi.org/10.1038/s41467-021-27038-5
Autor:
Robert E MacLaren, Harry O Orlans, Michelle E. McClements, Alun R. Barnard, Cristina Martinez-Fernandez de la Camara
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Rhodopsin (RHO) gene mutations are a common cause of autosomal dominant retinitis pigmentosa (ADRP). The need to suppress toxic protein expression together with mutational heterogeneity pose challenges for treatment development. Mirtrons are atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d763a884a5b2e72b00d42ebcc5cfa5
https://ora.ox.ac.uk/objects/uuid:d5255281-048a-4e08-ac4a-f0defc618a77
https://ora.ox.ac.uk/objects/uuid:d5255281-048a-4e08-ac4a-f0defc618a77
Autor:
Anders Moen, Jesper V. Olsen, Lisa Schroer, Ida A. Grønsberg, Niels Eijkelkamp, Albert Jeltsch, Takehiro Suzuki, Tadahiro Shimazu, Naoshi Dohmae, Erna Davydova, Mikiko Sodeoka, Valentina Siino, Mai Akakabe, Jędrzej Małecki, Pål Ø. Falnes, Michael A. McDonough, Takashi Umehara, Yoshihiro Sohtome, Magnus E. Jakobsson, Angela Ho, Rita Pinto, Masaki Kikuchi, Sara Weirich, Christopher J. Schofield, Yoichi Shinkai, Hanneke L.D.M. Willemen, Maren Kirstin Schuhmacher, Tongri Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Davydova, E, Shimazu, T, Schuhmacher, M K, Jakobsson, M E, Willemen, H L D M, Liu, T, Moen, A, Ho, A Y Y, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, I A, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, J V, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, M A, Eijkelkamp, N, Schofield, C J, Jeltsch, A, Shinkai, Y & Falnes, P 2021, ' The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes ', Nature Communications, vol. 12, 891 . https://doi.org/10.1038/s41467-020-20670-7
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8df554296bacb78fc88ad2f9d35057
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
https://ora.ox.ac.uk/objects/uuid:5d2edc4d-b490-4789-a8f9-e3a23c7392d4
Publikováno v:
Sharma, Puneet; Wu, Jie; Nilges, Benedikt S.; Leidel, Sebastian A. (2021). Humans and other commonly used model organisms are resistant to cycloheximide-mediated biases in ribosome profiling experiments. Nature Communications, 12(1), p. 5094. Springer Nature 10.1038/s41467-021-25411-y
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ribosome profiling measures genome-wide translation dynamics at sub-codon resolution. Cycloheximide (CHX), a widely used translation inhibitor to arrest ribosomes in these experiments, has been shown to induce biases in yeast, questioning its use. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dea5cae60549e3ad89cdfae2553dc5c
https://boris.unibe.ch/160036/1/NATURE_COMMUNICATIONS_2021_.pdf
https://boris.unibe.ch/160036/1/NATURE_COMMUNICATIONS_2021_.pdf
Autor:
Yun-Ru Chen, Lee-Way Jin, Yu Sheng Fang, Yao Hsiang Shih, Ling Hsien Tu, Wei Wei Chang, Yeh Tung Lin, Kiruthika Ganesan, Pao Sheng Chang, Ting Yu Chang
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
TDP-43 inclusions are found in many Alzheimer’s disease (AD) patients presenting faster disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187131f111a6378df3c13344a8d36c5
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Yohei Kawana, Kei Takahashi, Keizo Kaneko, Shinjiro Kodama, Vladimir V. Kalinichenko, Tetsuya Yamada, Shojiro Sawada, Junta Imai, Yoichiro Asai, Akira Endo, Tomohito Izumi, Kenji Uno, Hideki Katagiri, Junpei Yamamoto, Junhong Gao, Masato Kohata, Hiroto Sugawara, Yasushi Ishigaki
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The liver possesses a high regenerative capacity. Liver regeneration is a compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that a vagus-macrophage-hepatocyte link regulates acute liver re
Autor:
Paulina Siejka-Zielińska, Jinfeng Chen, Jingfei Cheng, Chun-Xiao Song, Yibin Liu, Zhiyuan Hu, Masato Inoue, Ahmed Ashour Ahmed
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Although various methods have been developed for sequencing cytosine modifications, it is still challenging for specific and quantitative sequencing of individual modification at base-resolution. For example, to obtain both true 5-methylcytosine (5mC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b103451534a791d53089c2344d648bb
https://ora.ox.ac.uk/objects/uuid:b9d4284d-e5fc-4a1d-8a24-bfc7d4b8749b
https://ora.ox.ac.uk/objects/uuid:b9d4284d-e5fc-4a1d-8a24-bfc7d4b8749b
Autor:
Agostinho Carvalho, Johan Maertens, Marina Botto, Toine Mercier, Tilo Schorn, João F. Lacerda, Barbara Bottazzi, Katrien Lagrou, Ilaria Laface, António Campos, Sarah N. Mapelli, Francesca Petroni, Elena Magrini, Alberto Mantovani, Antonio Inforzato, John D. Lambris, Cristina Cunha, Raffaella Parente, Federico Colombo, Rémi Porte, Andrea Doni, Cecilia Garlanda
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b919d27fbbddc19312122cdb01b1a873
Autor:
Antonio Garcia-Gomez, Laura San-Segundo, Laura Ciudad, Manel Esteller, Xabier Morales, Esteban Ballestar, Javier Rodríguez-Ubreva, Carlos Ortiz-de-Solorzano, Julen Oyarzabal, Felipe Prosper, Mercedes Garayoa, Tianlu Li, Sandra Muntión, Montserrat Martín-Sánchez, Xabier Agirre, Edurne San José-Enériz, Carlos de la Calle-Fabregat, Gerard Godoy-Tena, Francesc Català-Moll
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digital.CSIC. Repositorio Institucional del CSIC
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digital.CSIC. Repositorio Institucional del CSIC
© The Author(s) 2021.
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epige
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe16b4cd0ce50169152c027ce7ca5a9
http://hdl.handle.net/2445/174307
http://hdl.handle.net/2445/174307