Zobrazeno 1 - 10
of 13
pro vyhledávání: ''
Autor:
Kristina Zec, Roman Fischer, Irina A. Udalova, Tariq E. Khoyratty, Claire Pearson, Hayley L. Eames, Benedikt M. Kessler, Hannah Almuttaqi, Grigory Ryzhakov, Simon Travis, Samuel J. Bullers, Luke Jostins-Dean, Alastair L. Corbin, Sarah Bonham, Zhichao Ai, Dorothée L. Berthold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8cfb57ebeee917922ddd5935776e62
https://doi.org/10.1038/s41467-021-27038-5
https://doi.org/10.1038/s41467-021-27038-5
Autor:
Chandrani Mukhopadhyay, Lesa D. Deonarine, Dennis Huang, Arul M. Chinnaiyan, Deli Liu, Yu Wang, Brian D. Robinson, Christopher E. Barbieri, Joanna Cyrta, Pengbo Zhou, Elai Davicioni, Chenyi Yang, Mark A. Rubin, Limei Xu, Andrea Sboner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mukhopadhyay, Chandrani; Yang, Chenyi; Xu, Limei; Liu, Deli; Wang, Yu; Huang, Dennis; Deonarine, Lesa Dayal; Cyrta, Joanna; Davicioni, Elai; Sboner, Andrea; Robinson, Brian D; Chinnaiyan, Arul M; Rubin, Mark A; Barbieri, Christopher E; Zhou, Pengbo (2021). G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nature Communications, 12(1), p. 6662. Springer Nature 10.1038/s41467-021-27024-x
Mukhopadhyay, Chandrani; Yang, Chenyi; Xu, Limei; Liu, Deli; Wang, Yu; Huang, Dennis; Deonarine, Lesa Dayal; Cyrta, Joanna; Davicioni, Elai; Sboner, Andrea; Robinson, Brian D; Chinnaiyan, Arul M; Rubin, Mark A; Barbieri, Christopher E; Zhou, Pengbo (2021). G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nature Communications, 12(1), p. 6662. Springer Nature 10.1038/s41467-021-27024-x
SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafb7b6620fd672c80f1eca55319f78b
Autor:
José Ríos, Amador Valladares, Irene Suárez-Pereira, Mónica Venegas-Calerón, José M. Monje-Moreno, Paula Sansigre, Sara Esteban-García, Marta Artal-Sanz, Manuel Muñoz, Javier Vitorica, Angel M. Carrión, Alicia Sánchez-García, Ana María Brokate-Llanos, Mercedes M. Pérez-Jiménez
Publikováno v:
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
12 Páginas.-- 5 Figuras
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase
Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128e349166f272ab02aca1badb82eb4c
Autor:
James E.N. Minchin, John F. Rawls, Julia El Sayed Moustafa, Nathan Denton, Fredrik Karpe, Marijana Todorčević, Constantinos Christodoulides, John P. Kemp, Nellie Y. Loh, David M. Evans, Anubha Mahajan, Mark I. McCarthy, Manu Verma, Celia L Gregson, Matt J. Neville, Kerrin S. Small, Katherine E. Pinnick
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6f2bebf972c47cc7176712a31a5b32
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
Autor:
Christopher F. Bennett, Steven P. Gygi, Elizabeth A. Perry, Pere Puigserver, John G. Doench, Eduardo Balsa, Mark P. Jedrychowski
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95f128f878290842de9ec12cc621065
http://hdl.handle.net/10261/222158
http://hdl.handle.net/10261/222158
Autor:
Yuto Yoshinari, Akira Nakamura, Hiromu Tanimoto, Hina Kosakamoto, Takumi Kamiyama, Ryo Hoshino, Ryusuke Niwa, Rena Matsuoka, Shu Kondo, Fumiaki Obata
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like hormones have been found across animal phyla, incretin-like EEC-derived horm
Autor:
Amjad Alkodsi, Elmo Saarentaus, Outi Kilpivaara, Mikko Seppänen, Mervi Aavikko, Minna Taipale, Riku Katainen, Pia Vahteristo, Auli Karhu, Tomas Tanskanen, Kari Kaikkonen, Rainer Lehtonen, Morgane Hilpert, Heikki Ristolainen, Ekaterina Morgunova, Jussi Taipale, Mitja I. Kurki, Aarno Palotie, Lauri A. Aaltonen, Markus J. Mäkinen, Outi Kuismin, Aurora Taira, Kaarle Franssila, Radek C. Skoda, Kari K. Eklund, Juhani Junttila, Silva Saarinen, Kristiina Aittomäki, Jaakko Niinimäki, Johanna Kondelin, Eevi Kaasinen, Elina A. M. Hirvonen, Olli Pietilainen, Kristiina Rajamäki, Davide G. Berta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6ed4cb89b20d91fa977ec6638ab13c
http://urn.fi/urn:nbn:fi-fe2019092529684
http://urn.fi/urn:nbn:fi-fe2019092529684
Autor:
Shinji Takeuchi, Yoshihiko Taniguchi, Kyoichi Kaira, Akihiro Yoshimura, Wei Wang, Shinji Atagi, Akihiro Nishiyama, Kunio Matsumoto, Xujun Han, Koji Fukuda, Hirokazu Taniguchi, Azusa Tanimoto, Tadaaki Yamada, Takeshi Suzuki, Isao Matsumoto, Akihiko Ishimura, Minoru Terashima, Kenji Kita, Rikinari Hanayama, Sachiko Arai, Tomoyoshi Yamano, Rong Wang, Koichi Takayama, Koshiro Ohtsubo, Seiji Yano, Kaname Yamashita, Hisanori Uehara
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing EGFR mutat
Autor:
Iori Itagaki, Masatsugu Ema, Hideaki Tsuchiya, Hiroyuki Izumi, Akihiro Kawauchi, Shinji Kume, Chizuru Iwatani, Ikuo Kawamoto, Teppei Iwakiri, Tomoyuki Tsukiyama, Koji Fukuda, Takahiro Nakagawa, Kenichi Kobayashi, Saori Nishio, Yasunari Seita, Kahoru Kitajima, Masataka Nakaya, Shinichiro Nakamura, Hiroshi Maegawa, Jun Matsushita, Ryuichi Nishinakamura
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However, the key pathological processes underlying cyst development and exacerbation in pre-symptomatic stages remain unknow
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
Autor:
Yutaka Suzuki, Kenichi Chiba, Kazunari Murakami, Mamoru Kato, Masaki Mori, Tetsuichi Yoshizato, Keishi Sugimachi, Ryutaro Uchi, Sho Nambara, Yohsuke Kuroda, Shotaro Sakimura, Koshi Mimori, Yusuke Matsui, Atsushi Niida, Satoru Miyano, Hidenari Hirata, Hidetoshi Eguchi, Shuhei Ito, Satoshi Nagayama, Taro Tobo, Yuichi Shiraishi, Tsutomu Daa, Mitsutaka Shuto, Haruto Nishida, Hiroyuki Aburatani, Tatsuhiro Shibata, Takaaki Masuda, Hisateru Komatsu, Kazutaka Yamada, Masaaki Kodama, Kensuke Fukuda, Ryo Ogawa, Shuto Hayashi, Tadayoshi Okimoto, Kazuhiro Mizukami, Tomoko Saito, Teppei Shimamura, Seishi Ogawa, Kazuhisa Okamoto, Yuichiro Doki, Takanori Hasegawa
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Advanced colorectal cancer harbors extensive intratumor heterogeneity shaped by neutral evolution; however, intratumor heterogeneity in colorectal precancerous lesions has been poorly studied. We perform multiregion whole-exome sequencing on ten earl