Zobrazeno 1 - 9
of 9
pro vyhledávání: ''
Autor:
Yun-Ru Chen, Lee-Way Jin, Yu Sheng Fang, Yao Hsiang Shih, Ling Hsien Tu, Wei Wei Chang, Yeh Tung Lin, Kiruthika Ganesan, Pao Sheng Chang, Ting Yu Chang
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
TDP-43 inclusions are found in many Alzheimer’s disease (AD) patients presenting faster disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187131f111a6378df3c13344a8d36c5
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
https://ora.ox.ac.uk/objects/uuid:fb36f9aa-6fd0-4b55-b6a0-09c5d1ec070c
Autor:
Rushika C. Wirasinha, Hong Ying Teh, Adam E. Handel, Stephen R. Daley, Benoit Roch, Saulius Žuklys, Stuart H. Orkin, Thomas Barthlott, Jean-Pierre de Villartay, Katrin Hafen, Georg A. Holländer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9e2439df69c3a497fbd82be6559f2d
https://doi.org/10.1038/s41467-021-24158-w
https://doi.org/10.1038/s41467-021-24158-w
Autor:
José Luis Trillo-Contreras, Pedro Gómez-Gálvez, Luis M. Escudero, Nieves Lara-Ureña, Andrea S. Bullones-Bolanos, Javier Vitorica, Miriam Echevarría, Rosana March-Díaz, Miguel Marchena, Jose Carlos Davila, Ana C. Sanchez-Hidalgo, Eloisa Herrera, Fernando de Castro, Jakob Körbelin, Antonia Gutierrez, Rocio González-Martínez, Alicia E. Rosales-Nieves, Raquel del Toro, Clara Ortega-de San Luis, Maria I. Alvarez-Vergara, Alberto Pascual, Pablo Vicente-Munuera, Manuel A. Sanchez-Garcia, Guiomar Rodriguez-Perinan, Martin Trepel, Francisco G. Scholl, Alberto Rábano, Javier Villadiego, Miguel Martin-Bornez, Beatriz Fernández-Gómez
Publikováno v:
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa049ed47a103e3d3ff4480d727c21b5
Autor:
Theodore S. Jardetzky, Georgios Skiniotis, Chensong Zhang, Luke F. Pennington, Silke Kleinboelting, Pascal Gasser, Alexander Eggel
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Antibody drugs exert therapeutic effects via a range of mechanisms, including competitive inhibition, allosteric modulation, and immune effector mechanisms. Facilitated dissociation is an additional mechanism where antibody-mediated “disruption”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4680202a24536052c4c588fb2ac753
Autor:
Daniel Brigger, Rahel Ruppli, Pascal Guntern, Theodore S. Jardetzky, Alexander Eggel, Svetlana S. Tarchevskaya, Silke Kleinboelting, Noemi Zbären, Pascal Gasser, Christoph Heusser
Publikováno v:
Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f87e01b9a61768d0b922f9bc49897
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf
Autor:
Jonathan W. Yewdell, Justin Malin, Izumi Ohigashi, Avinash Bhandoola, Yousuke Takahama, Yongge Zhao, Christelle Harly, Maggie Cam, Mina O. Seedhom, Michael C. Kelly, Jennifer E. Cowan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5498. ⟨10.1038/s41467-019-13465-y⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5498. ⟨10.1038/s41467-019-13465-y⟩
Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that
Autor:
Hironori Haga, Hirofumi Shibata, Bunya Kuze, Mio Kabata, Shingo Komura, Takuya Yamamoto, Akito Tanaka, Nao Sankoda, Yosuke Yamada, Satoko Sakurai, Knut Woltjen, Tomoyo Ukai, Yoshiya Kawaguchi, Yasuhiro Yamada, Yatsuji Ito
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors (1–3 d
Autor:
Javier Rangel-Moreno, Shabaana A. Khader, Kristin L. Griffiths, Maxim N. Artyomov, Terry D. Connell, Mushtaq Ahmed, Shibali Das, Jay K. Kolls, Kelly D. Moynihan, William Horne, Radha Gopal, Darrell J. Irvine
Publikováno v:
Nature
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039a941640f2f8f9ece4994982f1a14
http://hdl.handle.net/1721.1/107719
http://hdl.handle.net/1721.1/107719
Autor:
Natàlia Reixach, Salvador Ventura, Raul Insa, Ricardo Sant'Anna, Oscar Huertas, David Reverter, Adrián Velázquez-Campoy, Lei Z. Robinson, Sebastian Esperante, Nelson Ferreira, Maria Rosário Almeida, Pablo Gallego, Alda Pereira-Henriques, Irantzu Pallarès, Francisca Pinheiro, Núria Reig
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
13 pags, 6 figs, 1 tab. -- Supplementary information is available at the Publisher's web
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggrega
Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64234fcfaf7f7adcb8d807ac4da4df1f
http://hdl.handle.net/10261/255695
http://hdl.handle.net/10261/255695