Zobrazeno 1 - 10
of 265
pro vyhledávání: ''
Autor:
José González-Martínez, Andrzej W. Cwetsch, Javier Gilabert-Juan, Jesús Gómez, Guillermo Garaulet, Paulina Schneider, Guillermo de Cárcer, Francisca Mulero, Eduardo Caleiras, Diego Megías, Eva Porlan, Marcos Malumbres
Publikováno v:
Cell Death and Differentiation 29: 1474-1485 (2022).
Alteration of centrosome function and dynamics results in major defects during chromosome segregation and is associated with primary autosomal microcephaly (MCPH). Despite the knowledge accumulated in the last few years, why some centrosomal defects
Autor:
Helen J Knowles, Martin Philpott, Srinivasa R. Rao, Sarah J. B. Snelling, Quitterie C. Larrouture, Adam P. Cribbs
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative conditions including osteoarthritis, rheumatoid arthritis and primary bone sarcoma. This study explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca54015a618034d4a9a384cd501e35a
https://ora.ox.ac.uk/objects/uuid:83c153db-a50e-4698-a92b-343317d2b104
https://ora.ox.ac.uk/objects/uuid:83c153db-a50e-4698-a92b-343317d2b104
Autor:
White Mpj., Mary E. Deadman, Duncan Howie, Ioanna A. Rota, Roman Fischer, Nikolaus S. Trede, Adam E. Handel, Georg A. Holländer, Bergithe E Oftedal, Benedikt M. Kessler, N Prevot, Rick M. Maizels, Simon J. Davis, Erdinc Sezgin, Stefano Maio
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology, 4 (1)
Communications Biology
Communications Biology, 4 (1)
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdf286cea5a98cf4e6d87b3b8500a56
https://ora.ox.ac.uk/objects/uuid:98b26ca7-9dd0-4cff-b27c-f76d0324a584
https://ora.ox.ac.uk/objects/uuid:98b26ca7-9dd0-4cff-b27c-f76d0324a584
Autor:
Rita Alonaizan, Sophia Malandraki-Miller, Lisa C. Heather, Carolyn A. Carr, Colleen Lopez, Sonia Iftekhar, Arne A. N. Bruyneel, Fatemeh Kermani, Matthew Kerr, Ujang Purnama, Maria da Luz Sousa Fialho, Jan T. Czernuszka, Heba Hussain A. A. Al-Siddiqi, Rabia Nazir
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomyocytes. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960ef522e39221777096e12365d4810
https://ora.ox.ac.uk/objects/uuid:27ea348b-1957-4a24-8a09-6d7cd1f726f2
https://ora.ox.ac.uk/objects/uuid:27ea348b-1957-4a24-8a09-6d7cd1f726f2
Autor:
Atsuhiko Hikita, Ali Mobasheri, Tomoaki Sakamoto, Zivile Tachtamisevaite, Ilona Uzieliene, Eiva Bernotiene, Kazuto Hoshi, Edvardas Bagdonas, Giedrius Kvederas, Greta Rakauskiene
Publikováno v:
Stem cell research and therapy, London : BioMed Central Ltd, 2021, vol. 12, no. 1, art. no. 251, p. 1-16
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Stem Cell Research & Therapy
Background Due to its low capacity for self-repair, articular cartilage is highly susceptible to damage and deterioration, which leads to the development of degenerative joint diseases such as osteoarthritis (OA). Menstrual blood-derived mesenchymal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9163faf5844f7df95e73e87d855bf6c
http://urn.fi/urn:nbn:fi-fe2021070741218
http://urn.fi/urn:nbn:fi-fe2021070741218
Autor:
Marta G. Montero, Rocio Sotillo, Pablo Lujan, Andreas Hoffmann, Teresa Rubio, Maja Köhn, Martin Jechlinger, Judith Weyershaeuser
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Molecular Medicine (Berlin, Germany)
Universidad de Barcelona
Journal of Molecular Medicine (Berlin, Germany)
Expression of the phosphatase of regenerating liver-3 (PRL-3) is known to promote tumor growth in gastrointestinal adenocarcinomas, and the incidence of tumor formation upon inflammatory events correlates with PRL-3 levels in mouse models. These carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed807464d3c3245931f59389ac0d27c
http://hdl.handle.net/2445/178674
http://hdl.handle.net/2445/178674
Autor:
María C. Gómez-García, David Carro, Carolina Lobo, Francisco J. Alonso, Narkhyun Bae, José A. Campos-Sandoval, Raghavendra G. Mirmira, Laura Castilla, Carolina Cardona, José C. Paz, Antonia Gutierrez, Gert Lubec, Ana Peñalver, José M. Matés, Amada R. López de la Oliva, Juan A. Segura, Victoria Enrique, Mercedes Martín-Rufián, Marina García-Frutos, Javier Márquez, Fernando J. Sialana
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ffb163cafa20a6e4f277dae2bf7788
https://hdl.handle.net/10668/3878
https://hdl.handle.net/10668/3878
Autor:
Guillermo de Cárcer, Beatriz Ortigosa, Natalia Sanz-Gómez, David Santamaría, Marcos Malumbres, Alberto Gandarillas, Isabel de Pedro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death and Differentiation
instname
Cell Death and Differentiation
The cellular mechanisms controlling cell fate in self-renewal tissues remain unclear. Cell cycle failure often leads to an apoptosis anti-oncogenic response. We have inactivated Cdk1 or Polo-like-1 kinases, essential targets of the mitotic checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0386e71af1a33e7f60c6009ea5e53c27
http://hdl.handle.net/10261/222343
http://hdl.handle.net/10261/222343
Autor:
Miryam Cadenas, María Negrete, Victor M. Victor, Raquel Chapresto-Garzón, Francisco J. Padillo, Elena Navarro-Villarán, Jordi Muntané, María A. Rodríguez-Hernández, Miguel Ángel Gómez-Bravo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-10 (2020)
instname
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-10 (2020)
Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and Cabozantinib have shown non-inferior antitumoral activities compared with the corresponding recomm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae544078e88cc08defb3d5d97a8520d
http://hdl.handle.net/10261/235700
http://hdl.handle.net/10261/235700
Autor:
Stine Figenschau, János Haskó, Marit Seppola, Imola Wilhelm, Gunbjørg Svineng, Synnøve Magnussen, Judit Molnár, Tonje S. Steigedal, Elin Synnøve Hadler-Olsen, Jimita Prashant Toraskar, István A. Krizbai, Sonja E. Steigen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8d66b275e0a8d38a06bf8d6d8b834
https://hdl.handle.net/10037/18912
https://hdl.handle.net/10037/18912