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Autor:
Marta G. Montero, Rocio Sotillo, Pablo Lujan, Andreas Hoffmann, Teresa Rubio, Maja Köhn, Martin Jechlinger, Judith Weyershaeuser
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Molecular Medicine (Berlin, Germany)
Universidad de Barcelona
Journal of Molecular Medicine (Berlin, Germany)
Expression of the phosphatase of regenerating liver-3 (PRL-3) is known to promote tumor growth in gastrointestinal adenocarcinomas, and the incidence of tumor formation upon inflammatory events correlates with PRL-3 levels in mouse models. These carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed807464d3c3245931f59389ac0d27c
http://hdl.handle.net/2445/178674
http://hdl.handle.net/2445/178674
Autor:
Yuko Kitano, Akira Ohta, Maki Kotaka, Katsutaro Yasuda, Akira Watanabe, Chihiro Okada, Motonari Uesugi, Taro Toyoda, Kenji Osafune
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Current induction methods of hepatocytes from human induced pluripotent stem cells (hiPSCs) are neither low cost nor stable. By screening a chemical library of 1,120 bioactive compounds and known drugs, we identified the α1-adrenergic receptor agoni
Publikováno v:
Science China Life Sciences. 58(11):1126-1134
In heart disease, transforming growth factor-b1 (TGF-b1) converts fibroblasts into myofibroblasts, which synthesize and secrete fibrillar type I and III collagens. The purpose of the present study was to investigate how hydrogen sulfide (H 2 S) suppr
Autor:
Hui-Min Hu, Liu Yang, Yan-Wu Liu, Zhuojing Luo, Bo-Yuan Wei, Yan-shui Lin, Jin-Kang Zhang, Jing Fan, Shi Chen, Jin-Zhu Fan, Qi-Zhen He, Jian Liu, Guolin Meng
Publikováno v:
Molecular and Cellular Biochemistry
Estrogen deficiency is the main reason of bone loss, leading to postmenopausal osteoporosis, and estrogen replacement therapy (ERT) has been demonstrated to protect bone loss efficiently. Notch signaling controls proliferation and differentiation of
Publikováno v:
Saeed, H, Qiu, W, Chen, L, Flyvbjerg, A, Abdallah, B & Kassem, M 2015, ' Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway ', Biogerontology, vol. 16, no. 6, pp. 733-745 . https://doi.org/10.1007/s10522-015-9596-6
Saeed, H, Qiu, W, Li, C, Flyvbjerg, A, Abdallah, B M & Kassem, M 2015, ' Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway ', Biogerontology, vol. 16, no. 6, pp. 733-45 . https://doi.org/10.1007/s10522-015-9596-6
Biogerontology
Saeed, H, Qiu, W, Li, C, Flyvbjerg, A, Abdallah, B M & Kassem, M 2015, ' Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway ', Biogerontology, vol. 16, no. 6, pp. 733-45 . https://doi.org/10.1007/s10522-015-9596-6
Biogerontology
The contribution of deficient telomerase activity to age-related decline in osteoblast functions and bone formation is poorly studied. We have previously demonstrated that telomerase over-expression led to enhanced osteoblast differentiation of human
Publikováno v:
Stem Cell Reviews
Pluripotent stem cells offer an abundant and malleable source for the generation of differentiated cells for transplantation as well as for in vitro screens. Patterning and differentiation protocols have been developed to generate neural progeny from
Autor:
Cheng Cheng Zhang, JingJing J. Xie
Publikováno v:
Science China Life Sciences. 58(9):839-853
Ex vivo expansion of hematopoietic stem cells (HSCs) would benefit clinical applications in several aspects, to improve patient survival, utilize cord blood stem cells for adult applications, and selectively propagate stem cell populations after gene
Autor:
Grzegorz Kreiner, Rosanna Parlato
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Nucleoli are the sites where synthesis of rRNA and ribosomal assembly take place. Along with these “traditional” roles, the nucleolus controls cellular physiology and homeostasis. The cellular and molecular alterations associated with impaired nu
Autor:
Tomoki Naoe, Tomohiro Itoh, Yukihiro Akao, Yoshinori Ohtsuki, Masashi Ando, Yuko Ito, Nami Yamada, Yasuyuki Tsukamasa
Publikováno v:
Journal of Molecular Histology
Bone metastasis is often occurs in patients with prostate cancer. There is a vicious cycle for bone metastases involving prostate cancer cells, osteoblasts, and osteoclasts. Acting among those cells during the process of metastasis are several molecu
Autor:
Silvia Kurtovic, Daniel L. Farkas, Yao He, Ankur Gupta, Donald C. Dafoe, Jae Youn Hwang, Tina T. Ng, Gordon D. Wu, Dodanim Talavera-Adame
Publikováno v:
Stem cell reviews and reports, vol 7, iss 3
Stem Cell Reviews
Stem Cell Reviews
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentiation of insulin-producing β cells in vivo. However, it is unknown if ECs promote such differentiation in vitro. We investig