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Autor:
Piotr Gruca, Marta Dziedzicka-Wasylewska, Maciej Kuśmider, Joanna Solich, Paulina Pabian, Mariusz Papp, Agata Faron-Górecka, Dariusz Żurawek, Magdalena Kolasa, Kinga Szafran-Pilch
Publikováno v:
Psychopharmacology
Rationale The involvement of somatostatin (SST) and its receptors in the pathophysiology of depression and stress has been evidenced by numerous studies. Objectives The purpose of the present study was to find whether chronic mild stress (CMS), an an
Publikováno v:
Journal of Orthopaedic Surgery and Research
Background Epidural fibrosis often causes serious complications in patients after lumbar laminectomy and discectomy and is associated with the proliferation of fibroblasts. Suramin is known to have an obvious inhibitory effect on the coactions of man
Publikováno v:
Journal of Neuroinflammation
Background Tamoxifen, a selective estrogen receptor modulator, has successfully been used to treat several animal models of brain injury, but the underlying mechanisms remain unclear. This study was undertaken to evaluate the effect of tamoxifen on t
Autor:
Valeria Corradetti, Pasquale Esposito, Chiara Rocca, Francesco Frassoni, Teresa Valsania, Chiara Collesi, Marilena Gregorini, Giulia Bedino, Teresa Rampino, Francesca Bosio, Antonio Dal Canton, Carmelo Libetta, Eleonora Francesca Pattonieri
Publikováno v:
BMC Immunology
Background: In former studies we showed in a rat model of renal transplantation that Mesenchymal Stromal Cells (MSC) prevent acute rejection in an independent way of their endowing in the graft. In this study we investigated whether MSC operate by re
Publikováno v:
BMC Musculoskeletal Disorders
Background Femoral head osteonecrosis is frequently observed in patients treated with excessive corticosteroids. The objective of the current study was to establish a rat model to investigate the disruption of immune response in steroid-induced femor
Publikováno v:
BMC Gastroenterology, Vol 5, Iss 1, p 5 (2005)
BMC Gastroenterology
BMC Gastroenterology
Background Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide, is involved in the autonomic
Publikováno v:
BMC Neuroscience
BMC Neuroscience, Vol 9, Iss 1, p 19 (2008)
BMC Neuroscience, Vol 9, Iss 1, p 19 (2008)
Background Recent in vitro evidence indicates that blockade of 5-hydroxytryptamine (5-HT) receptor 3 (5-HT3) is able to confer protection in different models of neuronal injury. The purpose of the present study was to investigate the effect of tropis
Autor:
Weike Bao, John J. Lepore, Elena DeAngelis, Gavin C. Jones, Rob D Prince, Karpagam Aravindhan, Mathew Szapacs, Robert N. Willette, April M. Barbour, Beat M. Jucker, Lucy J Holt, Larry J. Jolivette
Publikováno v:
Cardiovascular Diabetology
Background Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit their therapeutic use in acut
Autor:
Robert Levenson, Elisabeth J. Van Bockstaele, Saranya Kittanakom, Jay Jin, Igor Stagljar, Victoria Wong, Wade H. Berrettini, Beverly A.S. Reyes
Publikováno v:
BMC Neuroscience, Vol 11, Iss 1, p 33 (2010)
BMC Neuroscience
BMC Neuroscience
Background Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). O