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Autor:
Roy Nitulescu, Tripthi Kamath, Marjolaine Gauthier-Loiselle, Annie Guerin, Anthony Masaquel, Kenneth More, Raluca Ionescu-Ittu, Nicholas Sicignano, Brian Barnett, Christopher Gallagher, Elizabeth Butts, Eric Q. Wu
Publikováno v:
Breast Cancer Research and Treatment
Trastuzumab reduces the risk of relapse in women with HER2-positive non-metastatic breast cancer, but little information exists on the timing of trastuzumab initiation. The study investigated the impact of delaying the initiation of adjuvant trastuzu
Autor:
Magda A Blaut, Thilo Dörk, Michael Bremer, Natalia Bogdanova, Evgeny N. Imyanitov, Hans Christiansen, Aglaya G. Iyevleva, Svetlana N. Abysheva, Anna P. Sokolenko, Margret Rave-Fränk
Publikováno v:
Breast Cancer Research and Treatment
Since germline mutations in the PALB2 (Partner and Localizer of BRCA2) gene have been identified as breast cancer (BC) susceptibility alleles, the geographical spread and risks associated with PALB2 mutations are subject of intense investigation. Pat
Autor:
Shirley W. Flatt, Cynthia A. Thomson, Vicky A. Newman, Ruth E. Patterson, Lisa A. Cadmus Bertram, Cheryl L. Rock, Nazmus Saquib, Wayne A. Bardwell, John P. Pierce, Loki Natarajan, Marcia L. Stefanick
Publikováno v:
Cancer Causes & Control
Cancer causes & control : CCC, vol 22, iss 3
Cancer causes & control : CCC, vol 22, iss 3
Objective Research suggests that physical activity is associated with improved breast cancer survival, yet no studies have examined the association between post-diagnosis changes in physical activity and breast cancer outcomes. The aim of this study
Autor:
Ahmad Awada, A. Douglas Laird, Geoffrey I. Shapiro, Patrick Schöffski, Sara M. Tolaney, Hovav Nechushtan, Chris A. Yasenchak, Eric P. Winer, Bridget O’Keeffe, I. G. Ron
Publikováno v:
Breast Cancer Research and Treatment
Breast cancer research and treatment, 160 (2
Breast cancer research and treatment, 160 (2
Purpose: Cabozantinib (XL184), a multi-targeted oral tyrosine kinase inhibitor with activity against MET, VEGFR2, AXL, and other tyrosine kinases, was assessed in a cohort of metastatic breast cancer (MBC) patients in a phase II randomized discontinu
Autor:
Hans-Peter Goertz, Amy Pugh, Juan Marcos Gonzalez, Vincent Antao, Christine Poulos, Eleftherios P. Mamounas
Publikováno v:
Annals of Surgical Oncology
Background This study aimed to assess the influence of disease- and patient-related factors on surgeons’ decisions to refer patients with early-stage breast cancer (EBC) for neoadjuvant systemic therapy (NST). Methods An online survey of United Sta
Autor:
Jae Hoo Park, In Sil Choi, In Hae Park, Jee Hyun Kim, Ki Hyeong Lee, Hee Jun Kim, Keon Uk Park, Hye Sook Han, Jiyeon Kim, So Young Yoon, Seock-Ah Im, Si Young Kim, Kyung Hae Jung, Moon Hee Lee, Eun Kyung Cho, Young Jin Choi, Joo Han Lim, Do-Youn Oh
Publikováno v:
Supportive Care in Cancer
Purpose Pegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted to determine the ad
Autor:
Guy Jerusalem, Bjørn Naume, Camilo Garcia, Robert E. Coleman, Marcus Thuresson, Martine Piccart, Anne Kirsti Aksnes, Patrick Flamen, Nancy Vobecky
Publikováno v:
Breast cancer research and treatment, 145 (2
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
Radium-223 dichloride (radium-223) mimics calcium and emits high-energy, short-range alpha-particles resulting in an antitumor effect on bone metastases. This open-label, phase IIa nonrandomized study investigated safety and short-term efficacy of ra
Autor:
Ji Yeon Sohn, Eun Sook Lee, Boyoung Park, Moon Jung Yang, Keun Seok Lee, Dong Ock Lee, Soo Jin Park, Moo Hyun Lee, Sun-Young Kong, See Youn Lee, Kyong-Ah Yoon, Myong Cheol Lim, Eun Hae Cho, Yoon Jung Chang
Publikováno v:
Breast Cancer Research and Treatment
Purpose We investigated the prevalence of BRCA1/2 small mutations and large genomic rearrangements in high risk breast cancer patients who attended a genetic counseling clinic. Methods In total 478 patients were assessed for BRCA1/2 mutations by dire
Autor:
Rachel McFarland, Shuwei Li, Jill S. Dolinsky, Mary Pritzlaff, Pia Summerour, Elizabeth C. Chao, David E. Goldgar, Fergus J. Couch, Hermela Shimelis, Patrick Reineke, Holly LaDuca
Publikováno v:
Breast Cancer Research and Treatment
Pritzlaff, Mary; Summerour, Pia; McFarland, Rachel; Li, Shuwei; Reineke, Patrick; Dolinsky, Jill S; et al.(2017). Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.. Breast cancer research and treatment, 161(3), 575-5586. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6n16d1bp
Pritzlaff, Mary; Summerour, Pia; McFarland, Rachel; Li, Shuwei; Reineke, Patrick; Dolinsky, Jill S; et al.(2017). Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.. Breast cancer research and treatment, 161(3), 575-5586. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6n16d1bp
Purpose Genetic predisposition to male breast cancer (MBC) is not well understood. The aim of this study was to better define the predisposition genes contributing to MBC and the utility of germline multi-gene panel testing (MGPT) for explaining the
Autor:
Nora Trabulsi, Robyn Tamblyn, Kristen Reidel, Ari N. Meguerditchian, Nancy E. Mayo, Mohammed O. Nassif, Stanimira Krotneva
Publikováno v:
Breast Cancer Research and Treatment
Radiotherapy (RT) after breast conserving surgery (BCS) represents the standard for local control of breast cancer (BC). However, variations in practice persist. We aimed to characterize the rate of RT consideration (or referral) after BCS and identi