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Autor:
Sally Tan, Pasi A. Jänne, John J. Wright, Katherine Larrabee, Hao Guo, Eric P. Winer, Sara M. Tolaney, Eliezer M. Van Allen, Elena Ivanova, Ian E. Krop, Beth Overmoyer, William H. Barry, Jane E. Brock, Geoffrey I. Shapiro, Cloud P. Paweletz, Nikhil Wagle
Publikováno v:
Investigational New Drugs
SummaryBackground MET expression and activation appear to be important for initiation and progression of triple-negative breast cancer. Tivantinib (ARQ 197) is an orally administered agent that targets MET, although recent preclinical data suggests t
Autor:
V. Bongers, Marike C. Kokke, Frits van den Wildenberg, Bob van Wely, Sjoerd G. Elias, Thijs van Dalen, Miranda F. Ernst, Inne H.M. Borel Rinkes, E. B. M. Theunissen, Joost van Gorp, J. H. Wijsman, Paul D. Gobardhan, Carmen C. van der Pol, Eva V. E. Madsen
Publikováno v:
Annals of Surgical Oncology
Background To evaluate the prognostic meaning of lymph node micrometastases in breast cancer patients. Methods Between January 2000 and January 2003, 1411 patients with a cT1-2N0 invasive breast carcinoma underwent surgery in 7 hospitals in the Nethe
Autor:
Bilge Pakiz, Cheryl L. Rock, Jeanne F. Nichols, Deborah L. Taylor, Shirley W. Flatt, Wayne A. Bardwell
Publikováno v:
Taylor, Deborah L.; Nichols, Jeanne F.; Pakiz, Bilgé; Bardwell, Wayne A.; Flatt, Shirley W.; & Rock, Cheryl L.(2010). Relationships Between Cardiorespiratory Fitness, Physical Activity, and Psychosocial Variables in Overweight and Obese Breast Cancer Survivors. International Journal of Behavioral Medicine: Official Journal of the International Society of Behavioral Medicine, 17(4), pp 264-270. doi: 10.1007/s12529-010-9076-y. Retrieved from: http://www.escholarship.org/uc/item/6c8526pp
International Journal of Behavioral Medicine
International Journal of Behavioral Medicine
Background Breast cancer survivors not only experience distressing physical symptoms associated with treatments, but also are faced with psychosocial challenges. Despite growing scientific evidence that physical activity (PA) may mitigate psychosocia
Publikováno v:
Supportive Care in Cancer
Purpose The aim of this study is to characterize the patterns of medication use by early-stage breast cancer (ESBC) survivors from diagnosis to 1 year post-chemotherapy. Methods A single-center longitudinal study was conducted with ESBC patients diag
Autor:
Hideyuki Harada, Satoshi Horiguchi, Koichi Mitsuya, Sachiko Yuen, Koiku Asakura, Yoko Nakasu, Tetsuo Nishimura, Masahiro Endo
Publikováno v:
Journal of Neuro-Oncology
Skull metastases are malignant bone tumors which are increasing in incidence. The objectives of this study were to characterize the MR imaging features, locations, and extent of metastatic skull tumors to determine the frequency of the symptomatic di
Autor:
Michał Matysiewicz, Anna Cieślińska, Jadwiga Snarska, Michał Tenderenda, Konrad Wroński, Elżbieta Kostyra, Edyta Sienkiewicz-Szłapka, Ewa Fiedorowicz, Beata Jarmołowska
Publikováno v:
Tumour Biology
Structure-dependent μ-opioid receptor (MOR) activity is an important element in cancer opioid analgesic effectiveness. It is widely accepted that guanine (G) substitution for adenine (A) at OPRM1 gene sequence position 118 changes receptor glycosyla
Autor:
Gunnar Mellgren, Sara Gandini, Andrea Decensi, Jennifer Gjerde, Aliana Guerrieri-Gonzaga, Line L. Haugan Moi, Ernst A. Lien, Valentina Aristarco
Publikováno v:
Breast Cancer Research and Treatment
Tamoxifen dosage is based on the one-dose-fits-all approach. The anticancer effect of tamoxifen is believed to be due to the metabolites, 4-hydroxytamoxifen (4OHtam), and 4-hydroxy-N-desmethyltamoxifen (4OHNDtam/endoxifen). These demethylated metabol
Autor:
Tarek Sahmoud, Yutaka Tokuda, Yoshiaki Rai, Hirotaka Iwase, Shozo Ohsumi, Hirofumi Mukai, Ashok Panneerselvam, Woo Chul Noh, Yoshinori Ito, Puttisak Puttawibul, Hideo Inaji, Tetiana Taran, Vichien Srimuninnimit, Hiroji Iwata, Norikazu Masuda, Takahiro Nakayama, Mona El-Hashimy, Shinzaburo Noguchi, Jun Horiguchi, Shinji Ohno, Katsumasa Kuroi, Byeong Woo Park
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background The addition of mTOR inhibitor everolimus (EVE) to exemestane (EXE) was evaluated in an international, phase 3 study (BOLERO-2) in patients with hormone-receptor-positive (HR+) breast cancer refractory to letrozole or anastrozole. The safe
Autor:
Lisette Stork-Sloots, Paul Richards, Stephanie Akbari, Femke A. de Snoo, Mark A. Gittleman, Jennifer Beatty, Charles Nash, Laura A. Lee, Danielle Boselli, Angela Mislowsky, Mary Murray, James T. Symanowski, Peter D. Beitsch, Pat Whitworth, Paul L. Baron, James Pellicane
Publikováno v:
Annals of Surgical Oncology
Background The prospective Neoadjuvant Breast Symphony Trial (NBRST) study found that MammaPrint/BluePrint functional molecular subtype is superior to conventional immunohistochemistry/fluorescence in situ hybridization subtyping for predicting patho
Publikováno v:
Familial Cancer
Triple-negative breast cancer (TNBC) is characterised by worse clinical outcome and poor prognosis. The alterations in the oncogenes and tumor suppressor genes as well as microsatellite instability (MSI) have been associated with breast cancer develo