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Autor:
James L. Thorne, Melina C. Teske, Robyn V. Broad, Andrew M. Hanby, Laura M. Wastall, Stacey J. Jones, Thomas A. Hughes
Publikováno v:
British Journal of Cancer
Background Triple negative breast cancers (TNBC) have poor prognoses despite aggressive treatment with cytotoxic chemotherapy. Cancer-associated fibroblasts (CAFs) are prominent in tumour stroma. Our hypothesis was that CAFs modulate chemotherapy sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027115557c95f3f47f1ecb119dec9f3d
Autor:
Hisashi Motomura, Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Shuhei Tomita, Koji Takada, Masahiko Ohsawa, Katsuyuki Takahashi, Kosei Hirakawa, Masaichi Ohira, Tsutomu Takashima, Takaharu Hatano
Publikováno v:
British Journal of Cancer
Background Immune responses in a tumour microenvironment can be evaluated by analysing tumour-infiltrating lymphocyte (TIL) density; this has been verified in the clinical setting. Although there are many reports on TIL density in primary tumours, li
Autor:
Zsuzsanna Varga, Thomas Ruhstaller, Ulrike Perriard, Dirk Klingbiel, Tilman T. Rau, Jean-Christophe Tille, Beat Thuerlimann, Hanne Hawle, Qiyu Li, Wolfram Jochum
Publikováno v:
Varga, Zsuzsanna; Li, Qiyu; Jochum, Wolfram; Perriard, Ulrike; Rau, Tilman; Tille, Jean-Christoph; Hawle, Hanne; Klingbiel, Dirk; Thuerlimann, Beat; Ruhstaller, Thomas (2019). Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort. Scientific reports, 9(1), p. 13534. Springer Nature 10.1038/s41598-019-49638-4
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol. 9, No 1 (2019) P. 13534
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol. 9, No 1 (2019) P. 13534
Scientific Reports
The assessment of Ki-67 in early-stage breast cancer has become an important diagnostic tool in planning adjuvant therapy, particularly for the administration of additional chemotherapy to hormone-responsive patients. An accurate determination of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ed0eb6c511bb431eb561f8c240921
Autor:
J. van Gorp, Th. van Dalen, E. V. E. Madsen, P. de Hooge, Paul D. Gobardhan, D. Geertsema, M. Albregts
Publikováno v:
Annals of Surgical Oncology
Background In breast cancer surgery, intraoperative frozen section (FS) analysis of sentinel lymph nodes (SLNs) enables axillary lymph node dissection (ALND) during the same operative procedure. In case of discordance between a “negative” FS anal
Autor:
Annemieke Witteveen, Imh Ingrid Vliegen, Joost M. Klaase, Gabe S. Sonke, Maarten Joost IJzerman, Sabine Siesling
Publikováno v:
Breast cancer research and treatment, 152(3), 627-636. Springer
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
The objective of this study was to develop and validate a time-dependent logistic regression model for prediction of locoregional recurrence (LRR) of breast cancer and a web-based nomogram for clinical decision support. Women first diagnosed with ear
Autor:
Lisa Vandermeer, Stan Z. Gertler, Nathaniel Bouganim, John Hilton, Roanne J. Segal, Daylily S. Ooi, Mark Clemons, G. Dranitsaris, Gregory R. Pond, Susan Dent, Iryna Kuchuk, Eitan Amir, Xinni Song, Sasha Mazzarello, Sean Hopkins, Christina L. Addison
Publikováno v:
Breast Cancer Research and Treatment
The optimal frequency of intravenous (IV) bisphosphonate administration is unclear. We thus performed a study evaluating the effects of switching from 3–4 to 12 weekly therapy in patients with biochemically defined low-risk bone metastases. Patient
Autor:
Sergio Maluta, Melvin J. Silverstein, Donald A. Goer, Gerd Fastner, Roland Reitsamer, Frank A. Vicini, David E. Wazer
Publikováno v:
Annals of Surgical Oncology
Background Two randomized intraoperative radiation therapy trials for early-stage breast cancer were recently published. The ELIOT Trial used electrons (IOERT), and the TARGIT-A Trial Update used 50-kV X-rays (IORT). These studies were compared for s
Autor:
Lisette Stork-Sloots, Paul Richards, Stephanie Akbari, Femke A. de Snoo, Mark A. Gittleman, Jennifer Beatty, Charles Nash, Laura A. Lee, Danielle Boselli, Angela Mislowsky, Mary Murray, James T. Symanowski, Peter D. Beitsch, Pat Whitworth, Paul L. Baron, James Pellicane
Publikováno v:
Annals of Surgical Oncology
Background The prospective Neoadjuvant Breast Symphony Trial (NBRST) study found that MammaPrint/BluePrint functional molecular subtype is superior to conventional immunohistochemistry/fluorescence in situ hybridization subtyping for predicting patho
Autor:
Robert A. Goldschmidt, Lisette Stork-Sloots, Massimo Cristofanilli, Jelle Wesseling, Katharine Yao, Mary Turk, Femke De Snoo
Publikováno v:
Breast Cancer Research and Treatment
Combined use of MammaPrint and a molecular subtyping profile (BluePrint) identifies disease subgroups with marked differences in long-term outcome and response to neo-adjuvant therapy. The aim of this study was to evaluate the prognostic value of mol
Publikováno v:
Pathology Oncology Research
A considerable subgroup of patients with early breast cancer does not address benefits of anthracycline based chemotherapy. The aim of this retrospective study was to investigate the effect of microvessel density (MVD) and status of p53 protein on 5-