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Autor:
Hisashi Motomura, Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Shuhei Tomita, Koji Takada, Masahiko Ohsawa, Katsuyuki Takahashi, Kosei Hirakawa, Masaichi Ohira, Tsutomu Takashima, Takaharu Hatano
Publikováno v:
British Journal of Cancer
Background Immune responses in a tumour microenvironment can be evaluated by analysing tumour-infiltrating lymphocyte (TIL) density; this has been verified in the clinical setting. Although there are many reports on TIL density in primary tumours, li
Autor:
J. van Gorp, Th. van Dalen, E. V. E. Madsen, P. de Hooge, Paul D. Gobardhan, D. Geertsema, M. Albregts
Publikováno v:
Annals of Surgical Oncology
Background In breast cancer surgery, intraoperative frozen section (FS) analysis of sentinel lymph nodes (SLNs) enables axillary lymph node dissection (ALND) during the same operative procedure. In case of discordance between a “negative” FS anal
Publikováno v:
Cancer Immunology, Immunotherapy
To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast
Autor:
Christian Schem, Dirk Bauerschlag, Thomas Löning, Olivera Batic, Katharina Tiemann, Walter Jonat, Martin H. Carstensen, Christian Röder, Nicolai Maass
Publikováno v:
Virchows Archiv. 454(2):203-210
Sentinel lymph node (SN) biopsy is part of the staging procedure in breast cancer patients. In this study, we compared an intraoperative tool named one-step nucleic acid amplification (OSNA) to our routine histological investigation. OSNA consists of
Publikováno v:
Breast Cancer Research and Treatment
Certain nuclear morphometric features measured in breast tumor tissue have been shown to predict the prognosis of breast cancer patients. However, the application of these features to predicting risk of breast cancer development has received little a
Publikováno v:
Breast Cancer Research and Treatment
Mammary gland morphology and physiology are supported by an underlying cellular differentiation hierarchy. Molecular features associated with particular cell types along this hierarchy may contribute to the biological and clinical heterogeneity obser
Autor:
Razelle Kurzrock, Maria Schwaederle, Sherri Z. Millis, David Arguello, Zoran Gatalica, Min Yan
Publikováno v:
Cancer Metastasis Reviews
Cancer metastasis reviews, vol 34, iss 1
Cancer metastasis reviews, vol 34, iss 1
Human epidermal growth factor receptor 2 (HER2) amplification/overexpression is an effective therapeutic target in breast and gastric cancer. Although HER2 positivity has been reported in other malignancies, previous studies generally focused on one
Autor:
V. Bongers, Marike C. Kokke, Frits van den Wildenberg, Bob van Wely, Sjoerd G. Elias, Thijs van Dalen, Miranda F. Ernst, Inne H.M. Borel Rinkes, E. B. M. Theunissen, Joost van Gorp, J. H. Wijsman, Paul D. Gobardhan, Carmen C. van der Pol, Eva V. E. Madsen
Publikováno v:
Annals of Surgical Oncology
Background To evaluate the prognostic meaning of lymph node micrometastases in breast cancer patients. Methods Between January 2000 and January 2003, 1411 patients with a cT1-2N0 invasive breast carcinoma underwent surgery in 7 hospitals in the Nethe
Autor:
Richard Barrett-Jolley, Ali Mobasheri
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Aquaporins are membrane proteins that play fundamental roles in water and small solute transport across epithelial and endothelial barriers. Recent studies suggest that several aquaporin proteins are present in the mammary gland. Immunohistochemical
Autor:
Hideyuki Harada, Satoshi Horiguchi, Koichi Mitsuya, Sachiko Yuen, Koiku Asakura, Yoko Nakasu, Tetsuo Nishimura, Masahiro Endo
Publikováno v:
Journal of Neuro-Oncology
Skull metastases are malignant bone tumors which are increasing in incidence. The objectives of this study were to characterize the MR imaging features, locations, and extent of metastatic skull tumors to determine the frequency of the symptomatic di