Zobrazeno 1 - 10
of 204
pro vyhledávání: ''
Autor:
Waleed S. Al Amri, William E. Hughes, James L. Thorne, Geoff Wells, Ian M. Carr, Brian V Hogan, Thomas A. Hughes, Fiona Langlands, Arindam Pramanik, Layla K. Younis, Stacey J. Jones, Sarah A. Harris, Eldo T. Verghese, Rebecca Millican-Slater, Nevine M.F. El Deeb, Mervat A. Hamza, Baek Kim, Noha Gwili
Publikováno v:
British Journal of Cancer
Background Breast cancer stem cells (BCSCs) are drivers of therapy-resistance, therefore are responsible for poor survival. Molecular signatures of BCSCs from primary cancers remain undefined. Here, we identify the consistent transcriptome of primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a64defdd7881cec05092b3963a5ac9
https://eprints.whiterose.ac.uk/174958/7/s41416-021-01484-w.pdf
https://eprints.whiterose.ac.uk/174958/7/s41416-021-01484-w.pdf
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Shichina Kannambath, Joy Burchell, Natalie Woodman, Fabio Grundland Freile, Julie Owen, Ester Pfeifer, Sarah E Pinder, Ulla Mandel, Thomas Noll, Richard Beatson, Rosamond Nuamah, Joyce Taylor-Papadimitriou, Cheryl Gillett, Rosalind Graham, Ihssane Bouybayoune, Domenico Cozzetto
Publikováno v:
Communications Biology
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee333a13b7e86e9384b8c9eaed7802b
https://pub.uni-bielefeld.de/record/2948753
https://pub.uni-bielefeld.de/record/2948753
Autor:
Nelofar Nargis, Gunjan Mandal, Samir Jana, Thomas A. Hughes, Soumya Chatterjee, Annesha Chatterjee, Laura M. Wastall, Himansu Roy, Arindam Bhattacharyya
Publikováno v:
British Journal of Cancer
BACKGROUND: Cancer-associated fibroblasts (CAFs) are known to impact on tumour behaviour, but the mechanisms controlling this are poorly understood. METHODS: Breast normal fibroblasts (NFs) or CAFs were isolated from cancers by laser microdissection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957384df57b4414e3eef66fa38c6c18b
https://eprints.whiterose.ac.uk/149993/8/s41416-019-0566-7.pdf
https://eprints.whiterose.ac.uk/149993/8/s41416-019-0566-7.pdf
Autor:
Rebeca M. Torrente-Rodríguez, Virginia Albiñana, Luisa María Botella, Francisco Sánchez-Sancho, Rosario Granados, Susana Campuzano, Tania Aguado, Angel Cuesta, José-María Sánchez-Puelles, Jose A. Garcia-Sanz, José M. Pingarrón, Silvia Santamaría, José A. Romero-Revilla
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
13 p.-5 fig-1 tab.
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236868995761f9671b3afde6e250aa62
http://hdl.handle.net/10261/188732
http://hdl.handle.net/10261/188732
Autor:
Elena Gómez-Marín, Sabrina Rivero, José A. Guerrero-Martínez, José C. Reyes, Jorge García-Martínez
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation. To identify chromatin and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0cd2f27d3087907ada3b110e995e03
Autor:
Carmen Citterio, Jesús M. Paramio, L. Francisco Lorenzo-Martín, Pedro M. Fernández-Salguero, Romain M. Larive, Javier Robles-Valero, Javier Conde, Xosé R. Bustelo, María J. Montero, Myriam Cuadrado, Mauricio Menacho-Márquez, Mª Ángeles Sevilla, Isabel Fernández-Pisonero, Sonia Rodríguez-Fdez, Mercedes Dosil, Ramón García-Escudero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncogene
instname
Oncogene
The bidirectional regulation of epithelial–mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that impinge on the stability of cell-to-cell contacts, cytoskeletal dynamics, and cell invas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469910d984fe5688feeee1cb2c4772cc
http://hdl.handle.net/10261/204097
http://hdl.handle.net/10261/204097
Publikováno v:
Breast Cancer Research : BCR
We read with interest the recent article by Roth and colleagues [1] reporting the findings of altered tumorspecific microRNAs (miRNAs) in sera of breast cancer patients. This report further substantiates emerging data suggesting that blood-based miRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37de41d6ad927b9cb6665402fe5e878
http://hdl.handle.net/10379/11894
http://hdl.handle.net/10379/11894
Autor:
Qiongchao Jiang, Bing Ou, Fengtao Liu, Jiyi Yao, Hui Zhi, Shao-Yun Hao, Xin Pan, Xiao-yun Xiao, Zizhuo Zhao, Bao-Ming Luo
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background There is an unmet need for specific and sensitive imaging techniques to assess the efficacy of breast cancer therapy, particularly Her-2-expressing cancers. Ultrasonic microbubbles are being developed for use as diagnostic and therapeutic
Autor:
Reiner Laus, Lisa Do, John R. Lombardo, Ulrike Dirmeier, Katie Dalpozzo, Alain Delcayre, Peter L. Schoonmaker, Ryan Rountree, Robin Steigerwald, Stefanie Mandl, Thierry Giffon
Publikováno v:
Cancer Immunology, Immunotherapy
MVA-BN®-HER2 is a new candidate immunotherapy designed for the treatment of HER-2-positive breast cancer. Here, we demonstrate that a single treatment with MVA-BN®-HER2 exerts potent anti-tumor efficacy in a murine model of experimental pulmonary m