Zobrazeno 1 - 10
of 70
pro vyhledávání: ''
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Shichina Kannambath, Joy Burchell, Natalie Woodman, Fabio Grundland Freile, Julie Owen, Ester Pfeifer, Sarah E Pinder, Ulla Mandel, Thomas Noll, Richard Beatson, Rosamond Nuamah, Joyce Taylor-Papadimitriou, Cheryl Gillett, Rosalind Graham, Ihssane Bouybayoune, Domenico Cozzetto
Publikováno v:
Communications Biology
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee333a13b7e86e9384b8c9eaed7802b
https://pub.uni-bielefeld.de/record/2948753
https://pub.uni-bielefeld.de/record/2948753
Autor:
Rebeca M. Torrente-Rodríguez, Virginia Albiñana, Luisa María Botella, Francisco Sánchez-Sancho, Rosario Granados, Susana Campuzano, Tania Aguado, Angel Cuesta, José-María Sánchez-Puelles, Jose A. Garcia-Sanz, José M. Pingarrón, Silvia Santamaría, José A. Romero-Revilla
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
13 p.-5 fig-1 tab.
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236868995761f9671b3afde6e250aa62
http://hdl.handle.net/10261/188732
http://hdl.handle.net/10261/188732
Autor:
Cecilia Gelfi, Luigi Minafra, Valentina Bravatà, Rossana Norata, Carmelo Lupo, Massimo Viola, Cristina Messa
Publikováno v:
BMC research notes 5 (2012): 343. doi:10.1186/1756-0500-5-343
info:cnr-pdr/source/autori:Luigi Minafra; Rossana Norata; Valentina Bravatà; Massimo Viola; Carmelo Lupo; Cecilia Gelfi; Cristina Messa./titolo:Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: a study report./doi:10.1186%2F1756-0500-5-343/rivista:BMC research notes/anno:2012/pagina_da:343/pagina_a:/intervallo_pagine:343/volume:5
BMC Research Notes
BMC Research Notes, Vol 5, Iss 1, p 343 (2012)
info:cnr-pdr/source/autori:Luigi Minafra; Rossana Norata; Valentina Bravatà; Massimo Viola; Carmelo Lupo; Cecilia Gelfi; Cristina Messa./titolo:Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: a study report./doi:10.1186%2F1756-0500-5-343/rivista:BMC research notes/anno:2012/pagina_da:343/pagina_a:/intervallo_pagine:343/volume:5
BMC Research Notes
BMC Research Notes, Vol 5, Iss 1, p 343 (2012)
Background Immortalized cancer cell lines are now well-established procedures in biomedicine for a more complete understanding of cellular processes in cancer. However, they are more useful in preparation of fresh tumour tissue, in order to obtain ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879cc7aa8288ebe6181e5c13b2617698
http://hdl.handle.net/10281/37353
http://hdl.handle.net/10281/37353
Autor:
Razelle Kurzrock, Maria Schwaederle, Sherri Z. Millis, David Arguello, Zoran Gatalica, Min Yan
Publikováno v:
Cancer Metastasis Reviews
Cancer metastasis reviews, vol 34, iss 1
Cancer metastasis reviews, vol 34, iss 1
Human epidermal growth factor receptor 2 (HER2) amplification/overexpression is an effective therapeutic target in breast and gastric cancer. Although HER2 positivity has been reported in other malignancies, previous studies generally focused on one
Autor:
Robert A. Goldschmidt, Lisette Stork-Sloots, Massimo Cristofanilli, Jelle Wesseling, Katharine Yao, Mary Turk, Femke De Snoo
Publikováno v:
Breast Cancer Research and Treatment
Combined use of MammaPrint and a molecular subtyping profile (BluePrint) identifies disease subgroups with marked differences in long-term outcome and response to neo-adjuvant therapy. The aim of this study was to evaluate the prognostic value of mol
Autor:
Heerma van Voss, Marise R., Schrijver, Willemijne A M E, Ter Hoeve, Natalie D., Hoefnagel, Laurien D., Manson, Quirine F., van der Wall, Elsken, Raman, Venu, van Diest, Paul J., Dutch Distant Breast Cancer Metastases Consortium, Distant Breast Cancer Metastases Consortium
Publikováno v:
Clinical & Experimental Metastasis, 34(1), 85–92. Springer Netherlands
Clinical & Experimental Metastasis, 34(1), 85-92. SPRINGER
Clinical & Experimental Metastasis
Clinical & Experimental Metastasis, 34(1), 85-92. SPRINGER
Clinical & Experimental Metastasis
Metastatic breast cancer remains one of the leading causes of death in women and identification of novel treatment targets is therefore warranted. Functional studies showed that the RNA helicase DDX3 promotes metastasis, but DDX3 expression was never
Autor:
Birgitte Bruun Rasmussen, Elisabeth D. Galsgaard, Louise Maymann Nitze, Martin W. Berchtold, Nanni Din, Vibe Luja Lund, Leif Christensen, Svetlana Panina
Publikováno v:
Nitze, L M, Galsgaard, E D, Din, N, Lund, V L, Rasmussen, B B, Berchtold, M W, Christensen, L & Panina, S 2013, ' Reevaluation of the proposed autocrine proliferative function of prolactin in breast cancer ', Breast Cancer Research and Treatment, vol. 142, no. 1, pp. 31-44 . https://doi.org/10.1007/s10549-013-2731-7
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment
The pituitary hormone prolactin (PRL) has been implicated in tumourigenesis. Expression of PRL and its receptor (PRLR) was reported in human breast epithelium and breast cancer cells. It was suggested that PRL may act as an autocrine/paracrine growth
Autor:
Zhaomei Mu, Massimo Cristofanilli, Sandra V. Fernandez, Zaiming Ye, Khoi Chu, Lucy Aburto-Chumpitaz, Jianming Pei, Kimberly M. Boley, Andres J. Klein-Szanto, R. K. Alpaugh, Yu Cao, Sankar Addya, Fredika M. Robertson, Yong Huang, Karthik Devarajan, Kathy Q. Cai
Publikováno v:
Breast Cancer Research and Treatment
Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer characterized by rapid proliferation, early metastatic development and poor prognosis. Since there are few preclinical models of IBC, there is a general lack of un
Autor:
Sungwoong Jang, Han-Byul Lee, Gyungyub Gong, Hee Jin Lee, Jae-Eun Ryu, Hyo-Ju Lee, Hyojin Lee, Woo-Chan Son, Woo-Sung Ahn, Hye-Jin Kim, Hyun-Ji Choi
Publikováno v:
BMC VETERINARY RESEARCH(12)
BMC Veterinary Research
BMC Veterinary Research
Background: Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits of Polycomb repressive compl