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of 494
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Autor:
Yan Zhang, Gang Wei, Yingmeng Ni, Yue Lu, Bin Li, Dan Li, Song Guo Zheng, Fuxiang Zhu, Ruihong Zhu, Zhijun Han, Qibin Leng, Yangyang Li, Shuaiwei Wang, Rui Liang, Guochao Shi, Andy Tsun, Haikun Wang, Hong-Xi Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
FOXP3+ Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector T-cell-like function. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ad2a5ee15b3c340bde12f4513c3f3
https://ora.ox.ac.uk/objects/uuid:1996d6b4-b2cc-4777-97ca-3e329d01e6bb
https://ora.ox.ac.uk/objects/uuid:1996d6b4-b2cc-4777-97ca-3e329d01e6bb
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Scientific Reports
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a18f50d25232d779a03a6ffd0ec8d2a
https://doi.org/10.1038/s41598-020-79813-x
https://doi.org/10.1038/s41598-020-79813-x
Autor:
Ivan Ahel, John Brognard, Evgeniia Prokhorova, Alessandra Peters, Ian Gibbs-Seymour, Sébastien Huet, Siham Zentout, Florian Zobel, Rebecca Smith, Valentina Zorzini, Thomas Agnew, Kira Schützenhofer, Marcin J. Suskiewicz, Joséphine Groslambert, Michael L. Nielsen, Dragana Ahel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Nature Communications, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, M L, Ahel, D, Huet, S, Suskiewicz, M J & Ahel, I 2021, ' Serine-linked PARP1 auto-modification controls PARP inhibitor response ', Nature Communications, vol. 12, no. 1, 4055 . https://doi.org/10.1038/s41467-021-24361-9
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Nature Communications, 2021, 12 (1), pp.4055. ⟨10.1038/s41467-021-24361-9⟩
Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, M L, Ahel, D, Huet, S, Suskiewicz, M J & Ahel, I 2021, ' Serine-linked PARP1 auto-modification controls PARP inhibitor response ', Nature Communications, vol. 12, no. 1, 4055 . https://doi.org/10.1038/s41467-021-24361-9
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins. Several PARP1 and PARP2 inhibitors are currently employed in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23a9429d24efc41f73633abb3451ab8
https://doi.org/10.1038/s41467-021-24361-9
https://doi.org/10.1038/s41467-021-24361-9
Autor:
A S Walker, Brian D. Marsden, T Peto, I Bell, Alison Howarth, Ruth Studley, E Y Jones, John N Newton, David I. Stuart, Emma Rourke, Koen B. Pouwels, Sarah Hoosdally, Philippa C Matthews, Jeremy Farrar, David W Eyre, Jia Wei, Nicole Stoesser, John Bell, Daniel Ayoubkhani, Ian Diamond, D Crook
Publikováno v:
Nature Microbiology
We report that in a cohort of 45,965 adults, who were receiving either the ChAdOx1 or the BNT162b2 SARS-CoV-2 vaccines, in those who had no prior infection with SARS-CoV-2, seroconversion rates and quantitative antibody levels after a single dose wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1871384515e8b2b32c5b67cd6b1386
https://doi.org/10.1038/s41564-021-00947-3
https://doi.org/10.1038/s41564-021-00947-3
Autor:
Rosa D. Hernansaiz-Ballesteros, Csenge Földi, Luca Cardelli, Attila Csikász-Nagy, László Nagy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
In eukaryotes the entry into mitosis is initiated by activation of cyclin-dependent kinases (CDKs), which in turn activate a large number of protein kinases to induce all mitotic processes. The general view is that kinases are active in mitosis and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b38aaf128ab0038c14d0d48657f956
https://ora.ox.ac.uk/objects/uuid:bd7e4367-dc64-4eaa-b534-25201a255c8f
https://ora.ox.ac.uk/objects/uuid:bd7e4367-dc64-4eaa-b534-25201a255c8f
Autor:
Sara Thodberg, Rita Del Giudice, Matias E. Moses, Tomas Laursen, Nikos S. Hatzakis, Amit V. Pandey, Yanet G. Bustamante, Flemming Jørgensen, Maria Natalia Rojas Velazquez, Cecilie Cetti Hansen, Shaheena Parween, Birger Lindberg Møller, Simon Bo Jensen, Camilla Knudsen, Magnus Berg Sletfjerding, Philip M. Lund, Johannes Thomsen, Patricia Rodríguez Castaño
Publikováno v:
Jensen, Simon Bo; Thodberg, Sara; Parween, Shaheena; Moses, Matias E.; Hansen, Cecilie C.; Thomsen, Johannes; Sletfjerding, Magnus B.; Knudsen, Camilla; Del Giudice, Rita; Lund, Philip M.; Castaño, Patricia R.; Bustamante, Yanet G.; Rojas Velazquez, Maria Natalia; Jørgensen, Flemming Steen; Pandey, Amit Vikram; Laursen, Tomas; Møller, Birger Lindberg; Hatzakis, Nikos S. (2021). Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase. Nature Communications, 12(1), p. 2260. Springer Nature 10.1038/s41467-021-22562-w
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Jensen, S B, Thodberg, S, Parween, S, Moses, M E, Hansen, C C, Thomsen, J, Sletfjerding, M B, Knudsen, C, Del Giudice, R, Lund, P M, Castaño, P R, Bustamante, Y G, Velazquez, M N R, Jørgensen, F S, Pandey, A V, Laursen, T, Møller, B L & Hatzakis, N S 2021, ' Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase ', Nature Communications, vol. 12, no. 1, 2260 . https://doi.org/10.1038/s41467-021-22562-w
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Jensen, S B, Thodberg, S, Parween, S, Moses, M E, Hansen, C C, Thomsen, J, Sletfjerding, M B, Knudsen, C, Del Giudice, R, Lund, P M, Castaño, P R, Bustamante, Y G, Velazquez, M N R, Jørgensen, F S, Pandey, A V, Laursen, T, Møller, B L & Hatzakis, N S 2021, ' Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase ', Nature Communications, vol. 12, no. 1, 2260 . https://doi.org/10.1038/s41467-021-22562-w
Metabolic control is mediated by the dynamic assemblies and function of multiple redox enzymes. A key element in these assemblies, the P450 oxidoreductase (POR), donates electrons and selectively activates numerous (>50 in humans and >300 in plants)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01559cb2dc61b0b1595ccbe1e3266cd4
https://boris.unibe.ch/155910/1/2021_NatureCommunications_s41467-021-22562-w.pdf
https://boris.unibe.ch/155910/1/2021_NatureCommunications_s41467-021-22562-w.pdf
Autor:
Rita Alonaizan, Sophia Malandraki-Miller, Lisa C. Heather, Carolyn A. Carr, Colleen Lopez, Sonia Iftekhar, Arne A. N. Bruyneel, Fatemeh Kermani, Matthew Kerr, Ujang Purnama, Maria da Luz Sousa Fialho, Jan T. Czernuszka, Heba Hussain A. A. Al-Siddiqi, Rabia Nazir
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the properties of adult cardiomyocytes. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960ef522e39221777096e12365d4810
https://ora.ox.ac.uk/objects/uuid:27ea348b-1957-4a24-8a09-6d7cd1f726f2
https://ora.ox.ac.uk/objects/uuid:27ea348b-1957-4a24-8a09-6d7cd1f726f2
Autor:
Anne E. Kiltie, Chee Kin Then, Sophie Ellermann, J.A. Newman, Junetha Syed, Ignacio Torrecilla, Iolanda Vendrell, Kristijan Ramadan, Juri Na, Roman Fischer
Publikováno v:
Cell Death & Disease
Cell death & disease, 12(2). Nature Publishing Group
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Cell death & disease, 12(2). Nature Publishing Group
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e55e65e62a3c0343b3c0eabc9e8bfa
https://doi.org/10.1038/s41419-021-03437-w
https://doi.org/10.1038/s41419-021-03437-w
Autor:
Sophie C. van der Horst, Fabrizio Martino, Haico van Attikum, Fred van Leeuwen, George M.C. Janssen, Kees Vreeken, Hanneke Vlaming, Leonie Kollenstart, Peter A. van Veelen
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, 11(1). NATURE RESEARCH
Scientific reports, 11(1):12795. Nature Publishing Group
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports, 11(1). NATURE RESEARCH
Scientific reports, 11(1):12795. Nature Publishing Group
17 p.-7 fig.
The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations, such as crotonylation, succinylation and butyrylation, yet their regulation
The collection of known posttranslational modifications (PTMs) has expanded rapidly with the identification of various non-acetyl histone lysine acylations, such as crotonylation, succinylation and butyrylation, yet their regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4531cda97f896631c39bdd32e2c9c3a3
http://hdl.handle.net/10261/244616
http://hdl.handle.net/10261/244616
Autor:
Jarkko Koivunen, Anne Heikkinen, Mikko A. J. Finnilä, Padmanabhan Anbazhagan, André H. Juffer, Hongmin Tu, Donald Gullberg, Jarmo Käpylä, Antti Kemppainen, Jyrki Heino, Ning Lu, Simo Saarakkala, Taina Pihlajaniemi
Publikováno v:
Cell and Tissue Research
Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that collagen XIII modulates tissue development and homeostasis. Integrins are a family of receptors that mediate signals from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c3bc7a4efd89e69237844b1855f3d
https://static-content.springer.com/esm/art:10.1007/s00441-020-03300-y/MediaObjects/441_2020_3300_MOESM1_ESM.pdf
https://static-content.springer.com/esm/art:10.1007/s00441-020-03300-y/MediaObjects/441_2020_3300_MOESM1_ESM.pdf