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Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Biblos-e Archivo. Repositorio Institucional de la UAM
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Scientific Reports
Biblos-e Archivo. Repositorio Institucional de la UAM
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The biological mechanisms involved in aseptic loosening include inflammation-associated and bone resorption-associated processes. Coordinated cellular actions result in biochemical imbalances with devastating consequences for the joint. Given that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a18f50d25232d779a03a6ffd0ec8d2a
https://doi.org/10.1038/s41598-020-79813-x
https://doi.org/10.1038/s41598-020-79813-x
Autor:
Sissel Ida Schmidt, Alberto Martínez-Serrano, Brent J. Ryan, Justyna Okarmus, Helle Bogetofte, Poul Hyttel, Morten Meyer, Matias Ryding, Silvia García-López
Publikováno v:
Scientific Reports
Okarmus, J, Bogetofte, H, Schmidt, S I, Ryding, M, García-López, S, Ryan, B J, Martínez-Serrano, A, Hyttel, P & Meyer, M 2020, ' Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation ', Scientific Reports, vol. 10, 10278 . https://doi.org/10.1038/s41598-020-67091-6
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
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Okarmus, J, Bogetofte, H, Schmidt, S I, Ryding, M, García-López, S, Ryan, B J, Martínez-Serrano, A, Hyttel, P & Meyer, M 2020, ' Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation ', Scientific Reports, vol. 10, 10278 . https://doi.org/10.1038/s41598-020-67091-6
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd5b25f7e042edf0f1ac3e6d8ea98f8
https://ora.ox.ac.uk/objects/uuid:dcd9c4e9-8459-438e-9d9b-2afb48b4266d
https://ora.ox.ac.uk/objects/uuid:dcd9c4e9-8459-438e-9d9b-2afb48b4266d
Autor:
Yuichi Sakamori, Naoki Nakajima, Toyohiro Hirai, Takahiro Tsuji, Akihiko Yoshizawa, Toshi Menju, Hiroaki Ozasa, Hitomi Ajimizu, Hiroshi Date, Hironori Yoshida, Yuto Yasuda, Tomoko Funazo, Masatoshi Yamazoe, Takashi Nomizo, Young Hak Kim
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expre
Autor:
Christopher F. Bennett, Steven P. Gygi, Elizabeth A. Perry, Pere Puigserver, John G. Doench, Eduardo Balsa, Mark P. Jedrychowski
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions. This bioenergetic failure is thought to underlie pathologies assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95f128f878290842de9ec12cc621065
http://hdl.handle.net/10261/222158
http://hdl.handle.net/10261/222158
Autor:
Miryam Cadenas, María Negrete, Victor M. Victor, Raquel Chapresto-Garzón, Francisco J. Padillo, Elena Navarro-Villarán, Jordi Muntané, María A. Rodríguez-Hernández, Miguel Ángel Gómez-Bravo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-10 (2020)
instname
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-10 (2020)
Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and Cabozantinib have shown non-inferior antitumoral activities compared with the corresponding recomm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae544078e88cc08defb3d5d97a8520d
http://hdl.handle.net/10261/235700
http://hdl.handle.net/10261/235700
Autor:
Stine Figenschau, János Haskó, Marit Seppola, Imola Wilhelm, Gunbjørg Svineng, Synnøve Magnussen, Judit Molnár, Tonje S. Steigedal, Elin Synnøve Hadler-Olsen, Jimita Prashant Toraskar, István A. Krizbai, Sonja E. Steigen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8d66b275e0a8d38a06bf8d6d8b834
https://hdl.handle.net/10037/18912
https://hdl.handle.net/10037/18912
Autor:
Susumu Inamoto, Yoshiro Itatani, Gen Nishikawa, Jun Nakagawa, Rei Mizuno, Kenji Kawada, Yoshiharu Sakai, Ryotaro Ogawa, Kosuke Toda
Publikováno v:
Cell Death and Disease, Vol 10, Iss 4, Pp 1-13 (2019)
Cell Death & Disease
Cell Death & Disease
Mesenchymal stem cells (MSCs) are recruited from BM to the stroma of developing tumors, where they serve as critical components of the tumor microenvironment by secreting growth factors, cytokines, and chemokines. The role of MSCs in colorectal cance
Autor:
Elena Gómez-Marín, Sabrina Rivero, José A. Guerrero-Martínez, José C. Reyes, Jorge García-Martínez
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 2, Pp 1-12 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation. To identify chromatin and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0cd2f27d3087907ada3b110e995e03
Autor:
Jonathan Schneider, Carol V. Robinson, Matthew K. Higgins, Harriet Lane-Serff, Shahid Mehmood, Mark Carrington, Sebastian Zoll
Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4b2190b8d336739ff37ff9c0317295
https://ora.ox.ac.uk/objects/uuid:2df7ab90-1194-4c34-a4ea-54033f855b60
https://ora.ox.ac.uk/objects/uuid:2df7ab90-1194-4c34-a4ea-54033f855b60
Autor:
Hirotaka Takahashi, Fuminori Tokunaga, Hidefumi Ito, Izuho Hatada, Takashi Ayaki, Seshiru Nakazawa, Kiyoko Kamei, Ryuichiro Ishitani, Ryohei Ishii, Kazuhiro Iwai, Izumi Takeyoshi, Tatsuya Sawasaki, Daisuke Oikawa, Hiroyuki Takeda, Hideshi Kawakami, Osamu Nureki
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the