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Publikováno v:
British Journal of Cancer
Background Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. Methods UK Biobank was used. Hormone concentrations were measured in serum collected in 2006–2010, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d482614b3e60f0e3b3fcf0d952cf3d1b
https://ora.ox.ac.uk/objects/uuid:2298adb9-eb05-46ad-ae36-48abd7ac39d1
https://ora.ox.ac.uk/objects/uuid:2298adb9-eb05-46ad-ae36-48abd7ac39d1
Autor:
James L. Thorne, Melina C. Teske, Robyn V. Broad, Andrew M. Hanby, Laura M. Wastall, Stacey J. Jones, Thomas A. Hughes
Publikováno v:
British Journal of Cancer
Background Triple negative breast cancers (TNBC) have poor prognoses despite aggressive treatment with cytotoxic chemotherapy. Cancer-associated fibroblasts (CAFs) are prominent in tumour stroma. Our hypothesis was that CAFs modulate chemotherapy sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027115557c95f3f47f1ecb119dec9f3d
Autor:
Zsuzsanna Varga, Thomas Ruhstaller, Ulrike Perriard, Dirk Klingbiel, Tilman T. Rau, Jean-Christophe Tille, Beat Thuerlimann, Hanne Hawle, Qiyu Li, Wolfram Jochum
Publikováno v:
Varga, Zsuzsanna; Li, Qiyu; Jochum, Wolfram; Perriard, Ulrike; Rau, Tilman; Tille, Jean-Christoph; Hawle, Hanne; Klingbiel, Dirk; Thuerlimann, Beat; Ruhstaller, Thomas (2019). Ki-67 assessment in early breast cancer: SAKK28/12 validation study on the IBCSG VIII and IBCSG IX cohort. Scientific reports, 9(1), p. 13534. Springer Nature 10.1038/s41598-019-49638-4
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol. 9, No 1 (2019) P. 13534
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol. 9, No 1 (2019) P. 13534
Scientific Reports
The assessment of Ki-67 in early-stage breast cancer has become an important diagnostic tool in planning adjuvant therapy, particularly for the administration of additional chemotherapy to hormone-responsive patients. An accurate determination of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ed0eb6c511bb431eb561f8c240921
Autor:
Arja Jukkola-Vuorinen, Anniina Jääskeläinen, Kirsi-Maria Haapasaari, Päivi Auvinen, Ylermi Soini, Peeter Karihtala
Publikováno v:
BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Background: The subtype of claudin-low breast cancer can be reliably determined only by gene-expression profiling. Attempts have been made to develop immunohistochemical surrogates, which nearly always focus on membranous claudin expression. Methods:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0882fc6ea4b5d717997d116945eea4b4
http://urn.fi/urn:nbn:fi-fe201804196713
http://urn.fi/urn:nbn:fi-fe201804196713
Autor:
Rezvan Esmaeili, Hassan Fazilaty, Ali-Akbar Zare, Mehrdad Asghari Estiar, Ali Zekri, Narges Jafarbeik-Iravani, Keivan Majidzadeh-A, Leila Farahmand
Carcinoembryonic antigen (CEA) family members play important roles in malignancies and are introduced as biomarkers in different types of cancers. Among them CEACAM19 (CEAL1) gene, a new member of the CEA family, remains to be fully elucidated. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1808b0df50460e3c4e3fc63b2eb78444
http://hdl.handle.net/10261/308379
http://hdl.handle.net/10261/308379
Autor:
A. Mc Cann, O. Mc Cormack, A Mc Goldrick, Michael J. Kerin, F. J. Cooke, Patricia Fitzpatrick, B. Flynn, Peter A. Dervan, Michele Harrison, Wen Y. Chung, E. Gallagher, Edward J. Fox
Publikováno v:
British Journal of Cancer
Growth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ Tyro3 receptor family has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed01896775f03c49259bece5931e206
http://hdl.handle.net/10379/12693
http://hdl.handle.net/10379/12693
Autor:
Mads Hald Andersen, Cathrin Ritter, Per thor Straten, Jürgen C. Becker, Rikke Sick Andersen, Inge Marie Svane, Rikke Bæk Sørensen
Publikováno v:
Cancer Immunology, Immunotherapy
With the aim to identify cyclin B1-derived peptides with high affinity for HLA-A2, we used three in silico prediction algorithms to screen the protein sequence for possible HLA-A2 binders. One peptide scored highest in all three algorithms, and the h
Autor:
Reiner Laus, Lisa Do, John R. Lombardo, Ulrike Dirmeier, Katie Dalpozzo, Alain Delcayre, Peter L. Schoonmaker, Ryan Rountree, Robin Steigerwald, Stefanie Mandl, Thierry Giffon
Publikováno v:
Cancer Immunology, Immunotherapy
MVA-BN®-HER2 is a new candidate immunotherapy designed for the treatment of HER-2-positive breast cancer. Here, we demonstrate that a single treatment with MVA-BN®-HER2 exerts potent anti-tumor efficacy in a murine model of experimental pulmonary m
Autor:
Pawel Jozwiak, Anna Krzeslak, Hanna Romanowicz, Katarzyna Wójcik-Krowiranda, Ewa Forma, Andrzej Bieńkiewicz, Magdalena Brys
Publikováno v:
Pathology Oncology Research
Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycoly
Autor:
Mark Laible, Päivi Auvinen, Sebastian Eidt, Harri Sihto, Heikki Joensuu, Taina Turpeenniemi-Hujanen, Ugur Sahin, Sirkku Jyrkkiö, Kornelia Schlombs, Ralph M. Wirtz, Stefan Weber, Pirkko-Liisa Kellokumpu-Lehtinen, Sotiris Lakis, Jorma Isola, Päivi Heikkilä
Publikováno v:
Breast Cancer Research and Treatment
The biological subtype of breast cancer influences the selection of systemic therapy. Distinction between luminal A and B cancers depends on consistent assessment of Ki-67, but substantial intra-observer and inter-observer variability exists when imm