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Publikováno v:
Journal of Human Genetics
Breast cancer is a heterogeneous disease that develops through a multistep process via the accumulation of genetic/epigenetic alterations in various cancer-related genes. Current treatment options for breast cancer patients include surgery, radiother
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Hege Edvarsen, Ana Lluch, Antonio Falcó, Laura J. van't Veer, Carlos Lozano-Asencio, Allan Balmain, Anne Lise Børresen-Dale, Joan Climent, Raimundo Cervera-Vidal, Vita Fedele, Rafa Tabares-Seisdedos, Irene Tadeo-Cervera, Sten Cornelissen, Jaume Forés-Martos, Julia Sierra-Roca, Marjanka Schmidt, Vessela N. Kristensen, Pilar Eroles, David A. Quigley
Publikováno v:
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
NPJ breast cancer, vol 7, iss 1
Fundación Universitaria San Pablo CEU (FUSPCEU)
npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
NPJ breast cancer, vol 7, iss 1
Polymorphisms in the PER3 gene have been associated with several human disease phenotypes, including sleep disorders and cancer. In particular, the long allele of a variable number of tandem repeat (VNTR) polymorphism has been previously linked to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe28842d1952d5013093a97ab6d336f5
https://doi.org/10.1038/s41523-021-00329-2
https://doi.org/10.1038/s41523-021-00329-2
Autor:
Shichina Kannambath, Joy Burchell, Natalie Woodman, Fabio Grundland Freile, Julie Owen, Ester Pfeifer, Sarah E Pinder, Ulla Mandel, Thomas Noll, Richard Beatson, Rosamond Nuamah, Joyce Taylor-Papadimitriou, Cheryl Gillett, Rosalind Graham, Ihssane Bouybayoune, Domenico Cozzetto
Publikováno v:
Communications Biology
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, 644 . https://doi.org/10.1038/s42003-020-01359-5
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Beatson, R, Graham, R, Grundland Freile, F, Cozzetto, D, Kannambath, S, Pfeifer, E, Woodman, N, Owen, J, Nuamah, R, Mandel, U, Pinder, S, Gillett, C, Noll, T, Bouybayoune, I, Taylor-Papadimitriou, J & Burchell, J M 2020, ' Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype ', Communications Biology, vol. 3, no. 1, 644 . https://doi.org/10.1038/s42003-020-01359-5
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee333a13b7e86e9384b8c9eaed7802b
https://pub.uni-bielefeld.de/record/2948753
https://pub.uni-bielefeld.de/record/2948753
Autor:
Stine Figenschau, János Haskó, Marit Seppola, Imola Wilhelm, Gunbjørg Svineng, Synnøve Magnussen, Judit Molnár, Tonje S. Steigedal, Elin Synnøve Hadler-Olsen, Jimita Prashant Toraskar, István A. Krizbai, Sonja E. Steigen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8d66b275e0a8d38a06bf8d6d8b834
https://hdl.handle.net/10037/18912
https://hdl.handle.net/10037/18912
Autor:
María Teresa Sánchez-Barrón, Ana I. Álvarez-Mercado, Carmen M Ruiz-Marín, Cándido Robles-Sánchez, Saturnino Reyes Lartategui, María José Sáez-Lara, María Belén Sánchez-Andujar, Mariana F. Fernández, Alejandro J. Pérez-Alonso, Ana Moreno-Delgado, Tania Gallart-Aragón, Natalia Chueca, Katia Torres-Martínez, Julio Plaza-Díaz, Federico García, Iris Reina-Pérez, Luis Fontana, Pablo Torné
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Cancer
instname
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Cancer
We would like to thank M Luisa Puertas-Martin and Isabel Manzano-Jimenez, nurses at the Unit of Mammary Pathology, General Surgery Service, San Cecilio University Hospital (Granada), without whose enthusiasm the enrolment of participants in Granada w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8509963333b0ca31ea8159ad28a282
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. The present study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c6999b0faba50194b29ac42fa622b8
https://hdl.handle.net/10919/86493
https://hdl.handle.net/10919/86493
Autor:
Michailidou, K., Hall, P., Gonzalez-Neira, A., Ghoussaini, M., Dennis, J., Milne, R.L., Schmidt, M.K., Chang-Claude, J., Bojesen, S.E., Bolla, M.K., Wang, Q., Dicks, E., Lee, A., Turnbull, C., Rahman, N., Fletcher, O., Peto, J., Gibson, L., Silva, I.D., Nevanlinna, H., Muranen, T.A., Aittomaki, K., Blomqvist, C., Czene, K., Irwanto, A., Liu, J.J., Waisfisz, Q., Meijers-Heijboer, H., Adank, M., Luijt, R.B. van der, Hein, R., Dahmen, N., Beckman, L., Meindl, A., Schmutzler, R.K., Muller-Myhsok, B., Lichtner, P., Hopper, J.L., Southey, M.C., Makalic, E., Schmidt, D.F., Uitterlinden, A.G., Hofman, A., Hunter, D.J., Chanock, S.J., Vincent, D., Bacot, F., Tessier, D.C., Canisius, S., Wessels, L.F.A., Haiman, C.A., Shah, M., Luben, R., Brown, J., Luccarini, C., Schoof, N., Humphreys, K., Li, J.M., Nordestgaard, B.G., Nielsen, S.F., Flyger, H., Couch, F.J., Wang, X.S., Vachon, C., Stevens, K.N., Lambrechts, D., Moisse, M., Paridaens, R., Christiaens, M.R., Rudolph, A., Nickels, S., Flesch-Janys, D., Johnson, N., Aitken, Z., Aaltonen, K., Heikkinen, T., Broeks, A., Van't Veer, L.J., Schoot, C.E. van der, Guenel, P., Truong, T., Laurent-Puig, P., Menegaux, F., Marme, F., Schneeweiss, A., Sohn, C., Burwinke, B., Zamora, M.P., Perez, J.I.A., Pita, G., Alonso, M.R., Cox, A., Brock, I.W., Cross, S.S., Reed, M.W.R., Sawyer, E.J., Tomlinson, I., Kerin, M.J., Miller, N., Henderson, B.E., Schumacher, F., Marchand, L. le, Andrulis, I.L., Knight, J.A., Glendon, G., Mulligan, A.M., Lindblom, A., Margolin, S., Hooning, M.J., Hollestelle, A., Ouweland, A.M.W. van den, Jager, A., Bui, Q.M., Stone, J., Dite, G.S., Apicella, C., Tsimiklis, H., Giles, G.G., Severi, G., Baglietto, L., Fasching, P.A., Haeberle, L., Ekici, A.B., Beckmann, M.W., Brenner, H., Muller, H., Arndt, V., Stegmaier, C., Swerdlown, A., Ashworth, A., Orr, N., Jones, M., Figueroa, J., Lissowska, J., Brinton, L., Goldberg, M.S., Labreche, F., Dumont, M., Winqvist, R., Pylkas, K., Jukkola-Vuorinen, A., Grip, M., Brauch, H., Hamann, U., Bruning, T., Radice, P., Peterlongo, P., Manouldan, S., Bonanni, B., Devilee, P., Tollenaar, R.A.E.M., Seynaeve, C., Asperen, C.J. van, Jakubowska, A., Lubinski, J., Jaworska, K., Durda, K., Mannermaa, A., Kataja, V., Kosma, V.M., Hartikainen, J.M., Bogdanova, N.V., Antonenkova, N.N., Dork, T., Kristensen, V.N., Anton-Culver, H., Slager, S., Toland, A.E., Edge, S., Fostira, F., Kang, D., Yoo, K.Y., Noh, D.Y., Matsuo, K., Ito, H., Iwata, H., Sueta, A., Wu, A.H., Tseng, C.C., Berg, D. van den, Stram, D.O., Shu, X.O., Lu, W., Gao, Y.T., Cai, H., Teo, S.H., Yip, C.H., Phuah, S.Y., Cornes, B.K., Hartman, M., Miao, H., Lim, W.Y., Sng, J.H., Muir, K., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Shen, C.Y., Hsiung, C.N., Wu, P.E., Ding, S.L., Sangrajrang, S., Gaborieau, V., Brennan, P., Mckay, J., Blot, W.J., Signorello, L.B., Cai, Q.Y., Zheng, W., Deming-Halverson, S., Shrubsole, M., Long, J.R., Simard, J., Garcia-Closas, M., Pharoah, P.D.P., Chenevix-Trench, G., Dunning, A.M., Benitez, J., Easton, D.F., Breast Ovarian Canc Susceptibility, Hereditary Breast Ovarian Canc Res, kConFab Investigators, Australian Ovarian Can Study Grp, GENICA Gene Environm Interaction B
Publikováno v:
Nature genetics, 45(4). Nature Publishing Group
Nature Genetics; Vol 45
Nature Genetics, 45(4), 353-361
Nature Genetics, 45(4), 353-361. Nature Publishing Group
Michailidou, K, Hall, P, Gonzalez-Neira, A, Ghoussaini, M, Dennis, J, Milne, R L, Schmidt, M K, Chang-Claude, J, Bojesen, S E, Bolla, M K, Wang, Q, Dicks, E, Lee, A, Turnbull, C, Rahman, N, Fletcher, O, Peto, J, Gibson, L, Silva, I D, Nevanlinna, H, Muranen, T A, Aittomaki, K, Blomqvist, C, Czene, K, Irwanto, A, Liu, J J, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, R B, Hein, R, Dahmen, N, Beckman, L, Meindl, A, Schmutzler, R K, Muller-Myhsok, B, Lichtner, P, Hopper, J L, Southey, M C, Makalic, E, Schmidt, D F, Uitterlinden, A G, Hofman, A, Hunter, D J, Chanock, S J, Vincent, D, Bacot, F, Tessier, D C, Canisius, S, Wessels, L F A, Haiman, C A, Shah, M, Luben, R, Brown, J C, Luccarini, C, Schoof, N, Humphreys, K, Li, J M, Nordestgaard, B G, Nielsen, S F, Flyger, H, Couch, F J, Wang, X S, Vachon, C, Stevens, K N, Lambrechts, D, Moisse, M, Paridaens, R, Christiaens, M R, Rudolph, A, Nickels, S, Flesch-Janys, D, Johnson, N, Aitken, Z, Aaltonen, K, Heikkinen, T, Broeks, A, van 't Veer, L J, van der Schoot, C E, Guenel, P, Truong, T, Laurent-Puig, P, Menegaux, F, Marme, F, Schneeweiss, A, Sohn, C, Burwinke, B, Zamora, M P, Perez, J I A, Pita, G, Alonso, M R, Cox, A, Brock, I W, Cross, S S, Reed, M W R, Sawyer, E J, Tomlinson, I, Kerin, M J, Miller, N, Benitez, J & Easton, D F 2013, ' Large-scale genotyping identifies 41 new loci associated with breast cancer risk ', Nature Genetics, vol. 45, no. 4, pp. 353-361 . https://doi.org/10.1038/ng.2563
Nature Genetics
Nature Genetics; Vol 45
Nature Genetics, 45(4), 353-361
Nature Genetics, 45(4), 353-361. Nature Publishing Group
Michailidou, K, Hall, P, Gonzalez-Neira, A, Ghoussaini, M, Dennis, J, Milne, R L, Schmidt, M K, Chang-Claude, J, Bojesen, S E, Bolla, M K, Wang, Q, Dicks, E, Lee, A, Turnbull, C, Rahman, N, Fletcher, O, Peto, J, Gibson, L, Silva, I D, Nevanlinna, H, Muranen, T A, Aittomaki, K, Blomqvist, C, Czene, K, Irwanto, A, Liu, J J, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, R B, Hein, R, Dahmen, N, Beckman, L, Meindl, A, Schmutzler, R K, Muller-Myhsok, B, Lichtner, P, Hopper, J L, Southey, M C, Makalic, E, Schmidt, D F, Uitterlinden, A G, Hofman, A, Hunter, D J, Chanock, S J, Vincent, D, Bacot, F, Tessier, D C, Canisius, S, Wessels, L F A, Haiman, C A, Shah, M, Luben, R, Brown, J C, Luccarini, C, Schoof, N, Humphreys, K, Li, J M, Nordestgaard, B G, Nielsen, S F, Flyger, H, Couch, F J, Wang, X S, Vachon, C, Stevens, K N, Lambrechts, D, Moisse, M, Paridaens, R, Christiaens, M R, Rudolph, A, Nickels, S, Flesch-Janys, D, Johnson, N, Aitken, Z, Aaltonen, K, Heikkinen, T, Broeks, A, van 't Veer, L J, van der Schoot, C E, Guenel, P, Truong, T, Laurent-Puig, P, Menegaux, F, Marme, F, Schneeweiss, A, Sohn, C, Burwinke, B, Zamora, M P, Perez, J I A, Pita, G, Alonso, M R, Cox, A, Brock, I W, Cross, S S, Reed, M W R, Sawyer, E J, Tomlinson, I, Kerin, M J, Miller, N, Benitez, J & Easton, D F 2013, ' Large-scale genotyping identifies 41 new loci associated with breast cancer risk ', Nature Genetics, vol. 45, no. 4, pp. 353-361 . https://doi.org/10.1038/ng.2563
Nature Genetics
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ce99d85e1e04916e33425529f5e91
http://hdl.handle.net/10379/12885
http://hdl.handle.net/10379/12885
Autor:
Cecilia Gelfi, Luigi Minafra, Valentina Bravatà, Rossana Norata, Carmelo Lupo, Massimo Viola, Cristina Messa
Publikováno v:
BMC research notes 5 (2012): 343. doi:10.1186/1756-0500-5-343
info:cnr-pdr/source/autori:Luigi Minafra; Rossana Norata; Valentina Bravatà; Massimo Viola; Carmelo Lupo; Cecilia Gelfi; Cristina Messa./titolo:Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: a study report./doi:10.1186%2F1756-0500-5-343/rivista:BMC research notes/anno:2012/pagina_da:343/pagina_a:/intervallo_pagine:343/volume:5
BMC Research Notes
BMC Research Notes, Vol 5, Iss 1, p 343 (2012)
info:cnr-pdr/source/autori:Luigi Minafra; Rossana Norata; Valentina Bravatà; Massimo Viola; Carmelo Lupo; Cecilia Gelfi; Cristina Messa./titolo:Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: a study report./doi:10.1186%2F1756-0500-5-343/rivista:BMC research notes/anno:2012/pagina_da:343/pagina_a:/intervallo_pagine:343/volume:5
BMC Research Notes
BMC Research Notes, Vol 5, Iss 1, p 343 (2012)
Background Immortalized cancer cell lines are now well-established procedures in biomedicine for a more complete understanding of cellular processes in cancer. However, they are more useful in preparation of fresh tumour tissue, in order to obtain ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879cc7aa8288ebe6181e5c13b2617698
http://hdl.handle.net/10281/37353
http://hdl.handle.net/10281/37353
Autor:
Ana Luísa Correia, Ana Sofia Ribeiro, Fernando Schmitt, Marc Bracke, Bárbara Sousa, Raquel Seruca, Joana Paredes, André Albergaria
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell-cell adhesion is an elementary process in normal epithelial cellular architecture. Several studies have shown the role mediated by cadherins in this process, besides their role in the maintenance of cell polarity, differentiation and cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678d05d177b8757189b519b779289408
https://hdl.handle.net/1822/67565
https://hdl.handle.net/1822/67565