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Autor:
Feng Jin, Fan Yao, Yanan Sun, Ayao Guo, Chong Liu, Quanxiu Jin, Chuifeng Fan, Xiaoyun Mao, Bo Li, Shu Guan
Publikováno v:
Tumour Biology
CXCR4 and its ligand CXCL12 can promote the proliferation, survival, and invasion of cancer cells. They have been shown to play an important role in regulating metastasis of breast cancer to specific organs. High CXCR4 expression was also correlated
Autor:
Zhu Liu, Jie Ran, Jun Zhou, Min Liu, Bing Yan, Youguang Luo, Dengwen Li, Xin Dong, Jie Chen, Ruming Liu
Publikováno v:
Protein & Cell
Paclitaxel is a microtubule-targeting agent widely used for the treatment of many solid tumors. However, patients show variable sensitivity to this drug, and effective diagnostic tests predicting drug sensitivity remain to be investigated. Herein, we
Autor:
Gwyn T. Williams, Carlos Caldas, Mirna Mourtada-Maarabouni, Andrew R. Green, Mark R. Pickard, Ian O. Ellis, Vanessa L. Hedge
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to
Publikováno v:
BMC Cancer
BMC Cancer, Vol 8, Iss 1, p 153 (2008)
BMC Cancer, Vol 8, Iss 1, p 153 (2008)
Background A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed that BCL2 protein expression
Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Publikováno v:
BMC Cancer
Background Although mammary microcalcification is frequently observed and has been associated with poor survival in patients with breast cancer, the genesis of calcification remains unclear. Carbonic anhydrase I (CA1) has been shown to promote calcif
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Autor:
Birgitte Bruun Rasmussen, Anne Katrine Duun-Henriksen, Sarah Larsen, Anne Vibeke Lænkholm, Christina Westmose Yde, Martin Bak, Anne E. Lykkesfeldt, Tove Kirkegaard
Publikováno v:
Larsen, S L, Yde, C W, Laenkholm, A-V, Rasmussen, B B, Duun-Henriksen, A K, Bak, M, Lykkesfeldt, A E & Kirkegaard, T 2015, ' Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer ', B M C Cancer, vol. 15, 239 . https://doi.org/10.1186/s12885-015-1210-4
BMC Cancer
BMC Cancer
BACKGROUND: Resistance to antiestrogen therapy is a major clinical challenge in the treatment of estrogen receptor α (ER)-positive breast cancer. The aim of the study was to explore the growth promoting pathways of antiestrogen resistant breast canc
Serum biomarker profiles and response to neoadjuvant chemotherapy for locally advanced breast cancer
Autor:
Brian M Nolen, Jeffrey R Marks, Shlomo Ta'san, Alex Rand, The Minh Luong, Yun Wang, Kimberly Blackwell, Anna E Lokshin
Publikováno v:
Breast Cancer Research : BCR
Introduction Neoadjuvant chemotherapy has become the standard of care for the diverse population of women diagnosed with locally advanced breast cancer. Serum biomarker levels are increasingly being investigated for their ability to predict therapy r
Publikováno v:
BMC Cancer
Background Breast cancer is one of the most deadly diseases in women. Inhibiting the synthesis of estrogen is effective in treating patients with estrogen-responsive breast cancer. Previous studies have demonstrated that use of cyclooxygenase (COX) i