Zobrazeno 1 - 10
of 153
pro vyhledávání: ''
Autor:
Denis Le Bihan, Hiroyoshi Isoda, Masako Kataoka, Mami Iima, Yuji Nakamoto, Hirohiko Imai, Akihiko Yoshizawa, Yuko Someya
Publikováno v:
Scientific Reports. 12
We investigated the associations of time-dependent DWI, non-Gaussian DWI, and CEST parameters with histological biomarkers in a breast cancer xenograft model. 22 xenograft mice (7 MCF-7 and 15 MDA-MB-231) were scanned at 4 diffusion times [Td = 2.5/5
Autor:
Marta Vilalta, Adam J. Krieg, Caiyun G. Li, Eui Jung Moon, Amato J. Giaccia, Jen-Tsan Chi, Edward E. Graves, Jacob G. Kirkland, Stephano S. Mello, Anh N. Diep, Marjan Rafat, Yu Miao, Edward L. LaGory, Laura D. Attardi, Kaushik N. Thakkar, Laura Castellini, Ik Jae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574b64acea8911667a49665037069c39
https://doi.org/10.1038/s41467-021-24631-6
https://doi.org/10.1038/s41467-021-24631-6
Autor:
Stine Figenschau, János Haskó, Marit Seppola, Imola Wilhelm, Gunbjørg Svineng, Synnøve Magnussen, Judit Molnár, Tonje S. Steigedal, Elin Synnøve Hadler-Olsen, Jimita Prashant Toraskar, István A. Krizbai, Sonja E. Steigen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8d66b275e0a8d38a06bf8d6d8b834
https://hdl.handle.net/10037/18912
https://hdl.handle.net/10037/18912
Autor:
Rebeca M. Torrente-Rodríguez, Virginia Albiñana, Luisa María Botella, Francisco Sánchez-Sancho, Rosario Granados, Susana Campuzano, Tania Aguado, Angel Cuesta, José-María Sánchez-Puelles, Jose A. Garcia-Sanz, José M. Pingarrón, Silvia Santamaría, José A. Romero-Revilla
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
instname
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
13 p.-5 fig-1 tab.
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Phenotypic drug discovery must take advantage of the large amount of clinical data currently available. In this sense, the impact of microRNAs (miRs) on human disease and clinical therapeutic responses is becoming increasingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236868995761f9671b3afde6e250aa62
http://hdl.handle.net/10261/188732
http://hdl.handle.net/10261/188732
Autor:
Carmen Citterio, Jesús M. Paramio, L. Francisco Lorenzo-Martín, Pedro M. Fernández-Salguero, Romain M. Larive, Javier Robles-Valero, Javier Conde, Xosé R. Bustelo, María J. Montero, Myriam Cuadrado, Mauricio Menacho-Márquez, Mª Ángeles Sevilla, Isabel Fernández-Pisonero, Sonia Rodríguez-Fdez, Mercedes Dosil, Ramón García-Escudero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncogene
instname
Oncogene
The bidirectional regulation of epithelial–mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that impinge on the stability of cell-to-cell contacts, cytoskeletal dynamics, and cell invas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469910d984fe5688feeee1cb2c4772cc
http://hdl.handle.net/10261/204097
http://hdl.handle.net/10261/204097
Autor:
Qiongchao Jiang, Bing Ou, Fengtao Liu, Jiyi Yao, Hui Zhi, Shao-Yun Hao, Xin Pan, Xiao-yun Xiao, Zizhuo Zhao, Bao-Ming Luo
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background There is an unmet need for specific and sensitive imaging techniques to assess the efficacy of breast cancer therapy, particularly Her-2-expressing cancers. Ultrasonic microbubbles are being developed for use as diagnostic and therapeutic
Publikováno v:
Breast Cancer Research and Treatment
Mammary gland morphology and physiology are supported by an underlying cellular differentiation hierarchy. Molecular features associated with particular cell types along this hierarchy may contribute to the biological and clinical heterogeneity obser
Autor:
Reiner Laus, Lisa Do, John R. Lombardo, Ulrike Dirmeier, Katie Dalpozzo, Alain Delcayre, Peter L. Schoonmaker, Ryan Rountree, Robin Steigerwald, Stefanie Mandl, Thierry Giffon
Publikováno v:
Cancer Immunology, Immunotherapy
MVA-BN®-HER2 is a new candidate immunotherapy designed for the treatment of HER-2-positive breast cancer. Here, we demonstrate that a single treatment with MVA-BN®-HER2 exerts potent anti-tumor efficacy in a murine model of experimental pulmonary m
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Understanding the complex events leading to formation of an epithelial-based organ such as the breast requires a detailed insight into the crosstalk between epithelial and stromal compartments. These interactions occur both through heterotypic cellul
Autor:
Richard Barrett-Jolley, Ali Mobasheri
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia
Aquaporins are membrane proteins that play fundamental roles in water and small solute transport across epithelial and endothelial barriers. Recent studies suggest that several aquaporin proteins are present in the mammary gland. Immunohistochemical