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Senescent cells promote tissue NAD + decline during ageing via the activation of CD38 + macrophages.
Autor:
Covarrubias AJ; Buck Institute for Research on Aging, Novato, CA, USA.; UCSF Department of Medicine, San Francisco, CA, USA., Kale A; Buck Institute for Research on Aging, Novato, CA, USA., Perrone R; Buck Institute for Research on Aging, Novato, CA, USA., Lopez-Dominguez JA; Buck Institute for Research on Aging, Novato, CA, USA., Pisco AO; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kasler HG; Buck Institute for Research on Aging, Novato, CA, USA., Schmidt MS; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Heckenbach I; Buck Institute for Research on Aging, Novato, CA, USA.; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Kwok R; Buck Institute for Research on Aging, Novato, CA, USA., Wiley CD; Buck Institute for Research on Aging, Novato, CA, USA., Wong HS; Buck Institute for Research on Aging, Novato, CA, USA., Gibbs E; Buck Institute for Research on Aging, Novato, CA, USA., Iyer SS; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Basisty N; Buck Institute for Research on Aging, Novato, CA, USA., Wu Q; Buck Institute for Research on Aging, Novato, CA, USA., Kim IJ; Buck Institute for Research on Aging, Novato, CA, USA., Silva E; Buck Institute for Research on Aging, Novato, CA, USA., Vitangcol K; Buck Institute for Research on Aging, Novato, CA, USA., Shin KO; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.; Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea., Lee YM; College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea., Riley R; Buck Institute for Research on Aging, Novato, CA, USA., Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA., Ott M; Gladstone Institutes, Virology and Immunology, San Francisco, CA, USA., Schilling B; Buck Institute for Research on Aging, Novato, CA, USA., Scheibye-Knudsen M; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Ishihara K; Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Japan., Quake SR; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Newman J; Buck Institute for Research on Aging, Novato, CA, USA.; UCSF Department of Medicine, San Francisco, CA, USA., Brenner C; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Diabetes & Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, USA., Campisi J; Buck Institute for Research on Aging, Novato, CA, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA, USA. everdin@buckinstitute.org.; UCSF Department of Medicine, San Francisco, CA, USA. everdin@buckinstitute.org.
Publikováno v:
Nature metabolism [Nat Metab] 2020 Nov; Vol. 2 (11), pp. 1265-1283. Date of Electronic Publication: 2020 Nov 16.