Zobrazeno 31 - 40
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Publikováno v:
BMC Cancer
BMC Cancer, Vol 12, Iss 1, p 257 (2012)
BMC Cancer, Vol 12, Iss 1, p 257 (2012)
Background Sulfotransferase 1A1 (SULT1A1) participates in the elimination of 4-hydroxy-tamoxifen (4-OH-TAM), which is one of the major active metabolites of tamoxifen (TAM). Homozygous SULT1A1 variant allele genotype has been associated with lower ca
Publikováno v:
Breast cancer research : BCR
Background Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may
Autor:
Rodney C.P. Go, James C. Barton, William W Hollowell, Ronald T. Acton, Amy L Dreibelbis, Ellen H Barton
Publikováno v:
BMC Cancer, Vol 4, Iss 1, p 47 (2004)
BMC Cancer
BMC Cancer
Background We sought to evaluate the hypothesis that the high incidence of cutaneous melanoma in white persons in central Alabama is associated with a predominance of Irish and Scots descent. Methods Frequencies of country of ancestry reports were ta
Autor:
Monika Mueller, Michael Pfreundschuh, Lynn Kerschenmeyer, Lorenz Truemper, Klaus Roemer, Markus Kreuz, Olfert Landt, Alain Wabo, Joerg Thomas Bittenbring, Frédérique Parisot, Alain Menzel
Publikováno v:
BMC Cancer
BMC Cancer, Vol 8, Iss 1, p 116 (2008)
BMC Cancer, Vol 8, Iss 1, p 116 (2008)
Background SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to induce apoptosis. Both polymorphis
Autor:
Carl H. June, Emily K. Bergsland, Jeffrey Schlom, Andy Lin, John Nemunaitis, Robert S. Warren, Kristen Hege, Stephen A. Sherwin, George A. Fisher, James G. Mcarthur
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, vol 5, iss 1
Journal for immunotherapy of cancer, vol 5, iss 1
BackgroundT cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CA
Autor:
Katarzyna Gębura, Katarzyna Bogunia-Kubik, Grzegorz Mazur, Tomasz Wróbel, Justyna Dzietczenia, Kazimierz Kuliczkowski
Publikováno v:
Medical Oncology (Northwood, London, England)
Among a variety of angiogenic factors involved in the B cell chronic lymphocytic leukemia (B-CLL), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were identified. Their levels have been regarded as prognostic mark
Publikováno v:
BMC Cancer
Background The simultaneous Occurrence of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) has been rarely reported. Most of these cases have been occurring more frequently as a secondary event in patients receiving chemotherapeuti
Autor:
Rosa M. Michel Ortega, Geraldine Villanueva-Rodríguez, Maria G Serna-Thomé, Consuelo Diaz-Romero, Luis Martinez, Oscar Arrieta, Diana Flores-Estrada, Karla Sánchez-Lara, Cindy M Rodríguez
Publikováno v:
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 50 (2010)
BMC Cancer, Vol 10, Iss 1, p 50 (2010)
Background A frequent manifestation of advanced NSCLC is malnutrition, even though there are many studies which relate it with a poor survival, its relation with toxicity has not yet been consistently reported. The aim of this study was to associate
Autor:
Kaouther Snoussi, Wijden Mahfoudh, Meriem Fekih, Ahmed Noureddine Helal, Hedi Khairi, Lotfi Chouchane, Noureddine Bouaouina
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 283 (2010)
BMC Cancer
BMC Cancer
Background Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implication of polymorphism (-251)
Autor:
Rolandas Gerbutavičius, Tadas Žvirblis, Ilma Tavorienė, Laimonas Griskevicius, Tumas Beinortas, Mindaugas Jurgutis
Publikováno v:
BMC Cancer
Background Currently available chronic myeloid leukaemia (CML) survival reports have originated from more affluent countries. Herein we report the entire country data on incidence and survival of CML, as well as penetrance of tyrosine kinase inhibito