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Autor:
Minnamaija Lintunen, Jari Sundström, Eva-Maria Birkman, Olli Carpén, Annika Ålgars, Raija Ristamäki
Publikováno v:
BMC Cancer
Background Approximately 50 % of gastric adenocarcinomas belong to a molecular subgroup characterised by chromosomal instability and a strong association with the intestinal histological subtype. This subgroup typically contains alterations in the re
Autor:
Liankun Gu, Dajun Deng, Jiafu Ji, Jun Zhang, Bu-Dong Zhu, Jin Gu, Baozhen Zhang, Xiang Zheng, Jing Zhou, James A. Wilson
Publikováno v:
BMC Cancer
Background CBX7 is a Polycomb group protein that shows variable expression changes in various cancers that are often contradictive. A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis. The purpose of this study is to
Autor:
Konstantin J. Dedes, Eleftherios P. Samartzis, Mathias K. Fehr, Daniel Fink, Patrick Imesch, Nicolas Samartzis, Rosmarie Caduff, André Fedier
Publikováno v:
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 463 (2011)
BMC Cancer, Vol 11, Iss 1, p 463 (2011)
Background Epigenetic regulation is an important mechanism leading to cancer initiation and promotion. Histone acetylation by histone deacetylases (HDACs) represents an important part of it. The development of HDAC inhibitors has identified the utili
Autor:
Stephen Yip, Howard John Lim, Katayoon Kasaian, Amy Lum, Esther Kong, Ying Ng, Hector Li-Chang, David F. Schaeffer, Steven J.M. Jones, David G. Huntsman
Publikováno v:
BMC Cancer
Background Adenocarcinomas of both the gastroesophageal junction and stomach are molecularly complex, but differ with respect to epidemiology, etiology and survival. There are few data directly comparing the frequencies of single nucleotide mutations
Autor:
Yoshihiro Matsuno, Toshiya Kamiyama, Tatsuzo Mizukami, Yutaka Hatanaka, Akinobu Taketomi, Hirofumi Kamachi, Yosuke Tsuruga, Tomoko Mitsuhashi
Publikováno v:
BMC Cancer
Background Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance. Although the association of CSC markers with clinicopathological outcomes after neoadjuvant chemoradiotherapy (NACRT) has been reported in
Publikováno v:
BMC Cancer
Background Tumor recurrence and metastasis are the most common reason for treatment failure. Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Ald
Autor:
Jo Van Dorpe, Filip Baert, Marc Peeters, Pieter Demetter, Jean-Luc Van Laethem, Nadine Van Roy, Alain Bols, Patrick Pauwels, Nancy Van Damme, Franki Speleman, Philippe Deron
Publikováno v:
BMC cancer, 10
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 189 (2010)
BMC CANCER
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 189 (2010)
BMC CANCER
With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically i
Autor:
Vassiliki Labropoulou, Spyros S. Skandalis, Katalin Dobra, Achilleas D. Theocharis, Nikos K. Karamanos, Eleni Likaki-Karatza, Haralabos P. Kalofonos, Panagiota Ravazoula
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 314 (2011)
BMC Cancer
BMC Cancer
Background Mammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequently over-expressed in variou
Autor:
Andrea Santarelli, Roberta Bacchiocchi, Pasquale Procacci, Domenico Ciavarella, Lorenzo Lo Muzio, Elisa Pierpaoli, Giulia Borghetti, Romina Rocchetti, Corrado Rubini, Francesca Fazioli, Pier Francesco Nocini
Publikováno v:
BMC Cancer, Vol 8, Iss 1, p 220 (2008)
BMC Cancer
BMC Cancer
Background Oral squamous cell carcinoma (OSCC) represents the most common oral malignancy. Despite recent advances in therapy, up to 50% of the cases have relapse and/or metastasis. There is therefore a strong need for the identification of new biolo
Autor:
Jin Seok Ahn, Yoon-La Choi, Hyun Jung Jun, Yeon Hee Park, Myung Hee Chang, Eun Yoon Cho, Min Jae Park, Young-Hyuck Im, Ji Eun Uhm, Do Hyoung Lim, Sang Hoon Ji, Kyoung Ha Kim, Seong Yoon Yi
Publikováno v:
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 527 (2010)
BMC Cancer, Vol 10, Iss 1, p 527 (2010)
Background We analyzed the responses to first line treatment and clinical outcomes of metastatic breast cancer patients treated with palliative doxorubicin/cyclophosphamide (AC) according to molecular cancer subtype. Methods A retrospective analysis