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pro vyhledávání: ''
Autor:
Maria Teresa Petrucci, Sara Petillo, Rossella Paolini, Chiara Pighi, Fabrizio Antonangeli, Alessandra Soriani, Cristina Capuano, Ricciarda Galandrini, Angela Santoni, Alessandra Zingoni, Rosa Molfetta, Cinzia Fionda, Marco Cippitelli, Abdelilah Mekhloufi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-13 (2021)
Cell Death & Disease
Cell death and disease 12 (2021). doi:10.1038/s41419-021-04104-w
info:cnr-pdr/source/autori:Petillo, Sara; Capuano, Cristina; Molfetta, Rosa; Fionda, Cinzia; Mekhloufi, Abdelilah; Pighi, Chiara; Antonangeli, Fabrizio; Zingoni, Alessandra; Soriani, Alessandra; Petrucci, Maria Teresa; Galandrini, Ricciarda; Paolini, Rossella; Santoni, Angela; Cippitelli, Marco/titolo:Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition/doi:10.1038%2Fs41419-021-04104-w/rivista:Cell death and disease/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Cell Death & Disease
Cell death and disease 12 (2021). doi:10.1038/s41419-021-04104-w
info:cnr-pdr/source/autori:Petillo, Sara; Capuano, Cristina; Molfetta, Rosa; Fionda, Cinzia; Mekhloufi, Abdelilah; Pighi, Chiara; Antonangeli, Fabrizio; Zingoni, Alessandra; Soriani, Alessandra; Petrucci, Maria Teresa; Galandrini, Ricciarda; Paolini, Rossella; Santoni, Angela; Cippitelli, Marco/titolo:Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition/doi:10.1038%2Fs41419-021-04104-w/rivista:Cell death and disease/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Multiple Myeloma (MM) is an incurable hematologic malignancy of terminally differentiated plasma cells (PCs), where immune interactions play a key role in the control of cancer cell growth and survival. In particular, MM is characterized by a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a36c6bd94bd6ee4eb254b7ce50f2b8e
http://hdl.handle.net/11573/1568857
http://hdl.handle.net/11573/1568857
Autor:
Akihiro Nakahata, Sachiko Iwai, Hanako Ohashi Ikeda, Hiroyuki Yoshitomi, Akira Ito, Shuichi Matsuda, Hiroshi Kuroki, Motoo Saito, Shinichiro Nakamura, Shinichi Kuriyama, Koichi Murata, Kohei Nishitani, Akira Kakizuka, Shigeo Yoshida, Tomoki Aoyama, Xiang Ji, Hiromu Ito
Publikováno v:
Scientific Reports
Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage ch
Autor:
Angela Liu, Daniel J. DeAngelo, Thomas Kindler, Katie Parker, Margaret M. Woo, Jeffrey W. Scott, Henry Miles Prince, Oliver G. Ottmann, Kapil N. Bhalla, Tamas Fischer, Kaushal Mishra, Andrew Spencer, Francis J. Giles, Peter Atadja
Panobinostat is a potent oral pandeacetylase inhibitor that leads to acetylation of intracellular proteins, inhibits cellular proliferation and induces apoptosis in leukemic cell lines. A phase Ia/II study was designed to determine the maximum-tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d1bdb7fcc1c3c660aa8c2b3f2dfb63
http://hdl.handle.net/10379/11111
http://hdl.handle.net/10379/11111
Autor:
Lei Jiang, Yanling Chen, Hai-Jie Hong, Liang-Yi Zhou, Ze-Wu Meng, Qiang Du, Feifei She, Min-Chao Liu
Publikováno v:
Tumour Biology
Gallbladder carcinoma (GBC) is the most common cancer of the biliary tract. Lymph node metastasis (LNM) is the major diffusion route of GBC and is a prognosis factor. The aim of study was to assess the potential of the serum VEGF-C and VEGF-D (sVEGF-
Autor:
Łukasz Matusiak, Jacek C Szepietowski, Grazyna Szybejko-Machaj, Aleksandra Zamirska, Piotr Dziegiel
Publikováno v:
Pathology Oncology Research
Metallothioneins (MT) are low-molecular weight proteins implicated in heavy metal detoxification, zinc and cooper homeostasis and cell protection against free radicals. In variety of cancers MT-overexpression was shown, but there are just a few studi
Autor:
Toshinori Chiba, Tappei Takada, Asahi Hishida, Seiko Shimizu, Masayuki Sakiyama, Kenji Wakai, Toru Shimizu, Akiyoshi Nakayama, Yukio Kato, Nariyoshi Shinomiya, Sayo Kawai, Takahiro Nakamura, Hiroshi Nakashima, Katsuhisa Inoue, Hiraku Ogata, Yuzo Takada, Nobuyuki Hamajima, Chisaki Ushiyama, Hirotaka Matsuo, Kimiyoshi Ichida, Takuya Shimizu, Yutaka Sakurai
Publikováno v:
Human Cell
Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels. From a viewpoint of urate handling in humans, gout patients can be divided into those with renal overload (ROL) gout with intestinal urate underexcre
Autor:
Swaminathan Padmanabhan Iyer, Maria R. Baer, Da Zhang, Jennifer Poon, Ivana Gojo, Edward A. Sausville, Yali Zhu, Karen Small, Rena G. Lapidus, Mariola Sadowska, Alison Walker, Ying Ming Jou, Rajat Bannerji, Eric J. Feldman
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Dinaciclib inhibits cyclin-dependent kinases 1, 2, 5, and 9 with a better therapeutic index than flavopiridol in preclinical studies. This study assessed the activity of dinaciclib in acute leukemia both in the clinic and in vitro. Methods Ad
Publikováno v:
BMC Cancer
Background Genetic variations in DNA double-strand break repair genes can influence the ability of a cell to repair damaged DNA and alter an individual’s susceptibility to cancer. We studied whether polymorphisms in DNA double-strand break repair g
Autor:
Niall C. Tebbutt, Joe Stephenson, Y. J. Hei, Ralph V. Boccia, Neil D Belman, Herbert Hurwitz, Cheng-Pang Hsu, Lee S. Rosen, Lori J. Wirth, Timothy J. Price, S. McCoy, Lara Lipton
Publikováno v:
BMC Cancer
Rosen, Lee S; Lipton, Lara; Price, Timothy J; Belman, Neil D; Boccia, Ralph V; Hurwitz, Herbert I; et al.(2013). The effect of different dosing regimens of motesanib on the gallbladder: a randomized phase 1b study in patients with advanced solid tumors. BMC Cancer, 13(1), 242. doi: http://dx.doi.org/10.1186/1471-2407-13-242. Retrieved from: http://www.escholarship.org/uc/item/5j47k5v4
Rosen, Lee S; Lipton, Lara; Price, Timothy J; Belman, Neil D; Boccia, Ralph V; Hurwitz, Herbert I; et al.(2013). The effect of different dosing regimens of motesanib on the gallbladder: a randomized phase 1b study in patients with advanced solid tumors. BMC Cancer, 13(1), 242. doi: http://dx.doi.org/10.1186/1471-2407-13-242. Retrieved from: http://www.escholarship.org/uc/item/5j47k5v4
Background Gallbladder toxicity, including cholecystitis, has been reported with motesanib, an orally administered small-molecule antagonist of VEGFRs 1, 2 and 3; PDGFR; and Kit. We assessed effects of motesanib on gallbladder size and function. Meth
Autor:
Ulf Hinz, Markus W. Büchler, Magdalene Herber, Jürgen Weitz, Moritz Koch, Ulrich Bork, Thomas Schmidt, Christine S. Falk, Nuh N. Rahbari
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 286 (2011)
BMC Cancer
BMC Cancer
Background The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pancreatic cancer. Methods Serum