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Autor:
Katsuhiko Yoshimoto, Toshiaki Sano, Masahiko Nakasono, Eiji Kudo, Toshihito Tanahashi, Mitsuo Shimada, Zhi Rong Qian, El Wang, Yoshimi Bando
Publikováno v:
British Journal of Cancer
Background: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differenti
Autor:
Mauro Piacentini, Matteo Marconi, Steno Sentinelli, Michele Gallucci, Walter Malorni, Laura Falasca, Vincenzo Pompeo, Cristiano Padula, Manuela Costantini, Francesco Torino, Mario Patrizio, Laura De Salvo
Publikováno v:
Apoptosis
Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer
Autor:
Charlotte Aaberg-Jessen, Bo Halle, Stine Skov Jensen, Bjarne Winther Kristensen, Nils Brünner, Unni Maria Rømer, Christian Bonde Pedersen, Sven Müller
Publikováno v:
Journal of Neuro-Oncology
Aaberg-Jessen, C, Halle, B, Jensen, S S, Müller, S, Rømer, U M, Pedersen, C B, Brünner, N & Kristensen, B W 2016, ' Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients ', Journal of Neuro-Oncology, vol. 130, no. 3, pp. 439-448 . https://doi.org/10.1007/s11060-016-2252-4
Aaberg-Jessen, C, Halle, B, Jensen, S S, Muller, S, Rømer, M U K, Pedersen, C B, Brünner, N & Kristensen, B W 2016, ' Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients ', Journal of Neuro-Oncology, vol. 130, no. 3, pp. 439-448 . https://doi.org/10.1007/s11060-016-2252-4
Aaberg-Jessen, C, Halle, B, Jensen, S S, Müller, S, Rømer, U M, Pedersen, C B, Brünner, N & Kristensen, B W 2016, ' Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients ', Journal of Neuro-Oncology, vol. 130, no. 3, pp. 439-448 . https://doi.org/10.1007/s11060-016-2252-4
Aaberg-Jessen, C, Halle, B, Jensen, S S, Muller, S, Rømer, M U K, Pedersen, C B, Brünner, N & Kristensen, B W 2016, ' Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients ', Journal of Neuro-Oncology, vol. 130, no. 3, pp. 439-448 . https://doi.org/10.1007/s11060-016-2252-4
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with poor prognosis and resistance towards chemotherapy in several cancer forms. In a previous study we found an association between a low TIMP-1 tumor immunoreactivity and increas
Autor:
Huan Lu, Jing-Hao Wang, Xiao-Ning Li, Wen-Ming Zhang, Wei-Wei Song, Xiao-Dan Zhang, Yun-Di Guo
Publikováno v:
Tumour Biology
Human epididymis protein 4 (HE4), represented as an epididymis-specific gene and designated a WAP four-disulfide core domain protein 2 (WFDC2), is amplified in many tumors. However, little is known about its clinical significance and biological funct
Autor:
Kazuma Fujimoto, Takayoshi Tsuchiya, Shin Kono, Jun Matsubayashi, Takuji Gotoda, Fuminori Moriyasu, Megumi Hara, Naoyuki Tominaga, Heike I. Grabsch, Matthew D. Hale, Chika Kusano, Takao Itoi
Publikováno v:
Gastric Cancer, 19(2), 553-560. Springer, Cham
Gastric Cancer
Gastric Cancer
Background: National guidelines recommend trastuzumab for treatment of patients with metastatic HER2-positive gastric cancer (GC). There is currently no guideline indicating the number of biopsy specimens and the location from which they should be ob
Autor:
Min Wang, Zhipeng Li, Chengyi Sun, Jie Xiao, Jianxin Jiang, Deng Yazhu, Chao Yu, Xingjun Guo, Feng Peng
Publikováno v:
Cellular Oncology (Dordrecht)
Purpose The prognosis of pancreatic cancer ranks among the worst of all cancer types, which is primarily due to the fact that during the past decades little progress has been made in its diagnosis and treatment. Here, we set out to investigate the ro
Autor:
Matthew J. Ellis, Cynthia X. Ma
Publikováno v:
Breast Cancer Research and Treatment
Neoadjuvant chemotherapy trials have consistently reported lower response rates in hormone receptor-positive (HR+) breast cancer when compared with HR− cases. Preoperative endocrine therapy has therefore become a logical alternative and has gained
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose The aim of this retrospective study was to investigate the effect of B cell lymphoma 2 (BCL-2) expression on disease-free survival (DFS) in 172 early breast cancer (BC) patients treated with anthracycline-based adjuvant chemotherapy. We have
Autor:
Marek Zawadzki, Iwona Bednarz-Misa, Katarzyna Neubauer, Sabina Górska, Andrzej Gamian, Małgorzata Krzystek-Korpacka, Jerzy Wiśniewski, Wojciech Witkiewicz
Publikováno v:
Cancer Immunology, Immunotherapy
Interleukin (IL)-7 is a cytokine essential for protective immunity, and it is considered as a promising agent for cancer immunotherapy. Recent studies, however, appear to associate IL-7 with aggressiveness of solid tumors. The IL-7 has been less stud
Autor:
Cathy B. Moelans, Paul J. van Diest, Anya N. A. Milne, Folkert H.M. Morsink, G. Johan A. Offerhaus
Publikováno v:
Cellular Oncology (Dordrecht)
Background The recent ToGA trial results indicated that trastuzumab is a new, effective, and well-tolerated treatment for HER2-positive gastric cancer (GC). Although GC mainly affects older patients, fewer than 10% of GC patients are considered early