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Autor:
Wiktoria Maria Suchorska, Jacek Kaczmarczyk, Magdalena Richter, Michał Stefan Lach, Tomasz Trzeciak
Publikováno v:
Annals of Biomedical Engineering
To improve the recovery of damaged cartilage tissue, pluripotent stem cell-based therapies are being intensively explored. A number of techniques exist that enable monitoring of stem cell differentiation, including immunofluorescence staining. This s
Autor:
Nissim Benvenisty, Tamar Golan-Lev, Sagiv Shifman, Juan-Carlos Biancotti, Neta Lavon, N. Buehler, Kavita Narwani, David Hill
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal
Human embryonic stem cells are derived from the inner cell mass of pre-implantation embryos. The cells have unlimited proliferation potential and capacity to differentiate into the cells of the three germ layers. Human embryonic stem cells are used t
Publikováno v:
Cellular and Molecular Life Sciences
Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. Stem cells are characterized by self-renewal, pluripotency, and quiescence; their long life span, limited capacity to dilute cellular was
Autor:
Raveh-Amit, H., Berzsenyi, S., Vas, V., Ye, D., Dinnyes, A.J., Biology of Reproductive Cells, Dep Gezondheidszorg Landbouwhuisdieren
Publikováno v:
Biogerontology
Biogerontology, 14, 573. Springer Netherlands
Biogerontology, 14, 573. Springer Netherlands
Aging is accompanied by reduced regenerative capacity of all tissues and organs and dysfunction of adult stem cells. Notably, these age-related alterations contribute to distinct pathophysiological characteristics depending on the tissue of origin an
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal
Bone marrow-derived mesenchymal stem cells can differentiate into a variety of adult cells. Brain-derived neurotrophic factor (BDNF) is briefly active during differentiation and induces mesenchymal stem cells to differentiate into nerve cells. In thi
Publikováno v:
Cellular and Molecular Life Sciences
Induced pluripotent stem (iPS) cells have attracted a great deal attention as a new pluripotent stem cell type that can be generated from somatic cells, such as fibroblasts, by introducing the transcription factors Oct3/4, Sox2, Klf4, and c-Myc. The
Autor:
Ke Huang, Juli Liu, Duanqing Pei, Wenhao Huang, Li Qin, Shubin Chen, Jinglei Cai, Zhenghui Su, Xiang Li, Guangjin Pan, Lihui Wang, Jie Liu, Pengfei Liu, Bei Jia
Publikováno v:
Science China Life Sciences. 57(2):162-170
The breakthrough development of induced pluripotent stem cells (iPSCs) raises the prospect of patient-specific treatment for many diseases through the replacement of affected cells. However, whether iPSC-derived functional cell lineages generate a de
Autor:
Onur Basak, Verdon Taylor
Publikováno v:
Cellular and Molecular Life Sciences. 66(6):1057-1072
The mammalian brain is a paradox of evolution. Although the advance in complexity of the human brain has exceeded the development of other organs, it has practically lost the ability to regenerate, and damage is repaired mainly by functional plastici
Autor:
Alison Murdoch, Oliver Clewes, Andrew Loughney, Kevin R. Gillinder, Maya Sieber-Blum, Alla Narytnyk
Publikováno v:
Stem Cell Reviews
Here we describe the isolation, characterisation and ex-vivo expansion of human epidermal neural crest stem cells (hEPI-NCSC) and we provide protocols for their directed differentiation into osteocytes and melanocytes. hEPI-NCSC are neural crest-deri
Autor:
Clifford Librach, Tanya Barretto, Ekaterina Shlush, Shlomit Kenigsberg, Sonja A. Swanson, Andrée Gauthier-Fisher, Leila Maghen, Sergey I. Moskovtsev
Publikováno v:
Stem Cell Research & Therapy
Background First trimester (FTM) and term human umbilical cord-derived perivascular cells (HUCPVCs), which are rich sources of mesenchymal stem cells (MSCs), can give rise to Sertoli cell (SC)-like as well as haploid germ cell (GC)-like cells in vitr