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Autor:
Chandrani Mukhopadhyay, Lesa D. Deonarine, Dennis Huang, Arul M. Chinnaiyan, Deli Liu, Yu Wang, Brian D. Robinson, Christopher E. Barbieri, Joanna Cyrta, Pengbo Zhou, Elai Davicioni, Chenyi Yang, Mark A. Rubin, Limei Xu, Andrea Sboner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Mukhopadhyay, Chandrani; Yang, Chenyi; Xu, Limei; Liu, Deli; Wang, Yu; Huang, Dennis; Deonarine, Lesa Dayal; Cyrta, Joanna; Davicioni, Elai; Sboner, Andrea; Robinson, Brian D; Chinnaiyan, Arul M; Rubin, Mark A; Barbieri, Christopher E; Zhou, Pengbo (2021). G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nature Communications, 12(1), p. 6662. Springer Nature 10.1038/s41467-021-27024-x
Mukhopadhyay, Chandrani; Yang, Chenyi; Xu, Limei; Liu, Deli; Wang, Yu; Huang, Dennis; Deonarine, Lesa Dayal; Cyrta, Joanna; Davicioni, Elai; Sboner, Andrea; Robinson, Brian D; Chinnaiyan, Arul M; Rubin, Mark A; Barbieri, Christopher E; Zhou, Pengbo (2021). G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer. Nature Communications, 12(1), p. 6662. Springer Nature 10.1038/s41467-021-27024-x
SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafb7b6620fd672c80f1eca55319f78b
Autor:
Martina Schifferer, Ludovico Cantuti-Castelvetri, Susanne A. Schneider, Sabina Tahirovic, Andrew P. Lieberman, Jasmin König, Lina Dinkel, Silva Hećimović, Laura Sebastian Monasor, Tatiana Bremova-Ertl, Lea Vidatic, Alessio Colombo, Stephan A. Müller, Stefan F. Lichtenthaler, Michael Strupp, Mikael Simons
Publikováno v:
Nature communications
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f3dd22cdadfd9d9d515dc2698deab
http://fulir.irb.hr/6941/
http://fulir.irb.hr/6941/
Autor:
Bernd J. Pichler, Jörg Köhl, Matthias Mezger, Ruslan Hlushchuk, Oliver Borst, Jeanette Erdmann, Triantafyllos Chavakis, David Haberthür, Roza Meyer-Saraei, Harald F. Langer, Christian M. Karsten, Henry Nording, Johannes Patzelt, Frederic Emschermann, Kai Knoepp, Robert Feil, Manuela Sauter, Ingo Eitel, Admar Verschoor, Moritz Meusel, Philipp von Hundelshausen, Reinhard Sauter, Emmanouil Chavakis, Anne Nording, Daniel Sedding, Lasse Baron, Meinrad Gawaz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nording, Henry; Baron, Lasse; Haberthür, David; Emschermann, Frederic; Mezger, Matthias; Sauter, Manuela; Sauter, Reinhard; Patzelt, Johannes; Knoepp, Kai; Nording, Anne; Meusel, Moritz; Meyer-Saraei, Roza; Hlushchuk, Ruslan; Sedding, Daniel; Borst, Oliver; Eitel, Ingo; Karsten, Christian M.; Feil, Robert; Pichler, Bernd; Erdmann, Jeanette; ... (2021). The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nature Communications, 12(1), p. 3352. Springer Nature 10.1038/s41467-021-23499-w
Nature Communications
Nording, Henry; Baron, Lasse; Haberthür, David; Emschermann, Frederic; Mezger, Matthias; Sauter, Manuela; Sauter, Reinhard; Patzelt, Johannes; Knoepp, Kai; Nording, Anne; Meusel, Moritz; Meyer-Saraei, Roza; Hlushchuk, Ruslan; Sedding, Daniel; Borst, Oliver; Eitel, Ingo; Karsten, Christian M.; Feil, Robert; Pichler, Bernd; Erdmann, Jeanette; ... (2021). The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nature Communications, 12(1), p. 3352. Springer Nature 10.1038/s41467-021-23499-w
Nature Communications
Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphylatoxin C5a-mediated activation of C5a receptor 1 (C5aR1) on platelets a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4266211e357741350719b6b9b7c3e23
Autor:
Christian C. Ruff, Ulrike Ehlert, Nico Stenz, Monika Brodmann Maeder, Marcus Grueschow, Jan Breckwoldt, Hanna Thörn, Birgit Kleim, Roland Bingisser, Aristomenis K. Exadaktylos
Publikováno v:
Grueschow, Marcus; Stenz, Nico; Thörn, Hanna; Ehlert, Ulrike; Breckwoldt, Jan; Brodmann, Monika; Exadaktylos, Aristomenis K.; Bingisser, Roland; Ruff, Christian C.; Kleim, Birgit (2021). Real-world stress resilience is associated with the responsivity of the locus coeruleus. Nature Communications, 12(1), p. 2275. Springer Nature 10.1038/s41467-021-22509-1
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8faa860550f5c4a1e421c6830e9d47c
https://boris.unibe.ch/157205/1/s41467-021-22509-1.pdf
https://boris.unibe.ch/157205/1/s41467-021-22509-1.pdf
Autor:
Theodore S. Jardetzky, Georgios Skiniotis, Chensong Zhang, Luke F. Pennington, Silke Kleinboelting, Pascal Gasser, Alexander Eggel
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Antibody drugs exert therapeutic effects via a range of mechanisms, including competitive inhibition, allosteric modulation, and immune effector mechanisms. Facilitated dissociation is an additional mechanism where antibody-mediated “disruption”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4680202a24536052c4c588fb2ac753
Autor:
Britta Bruegger, Carolin Zitzmann, Christian Luechtenborg, Ji-Young Lee, Mirko Cortese, Cong Si Tran, Uta Haselmann, Keisuke Tabata, Juergen Beneke, Vibhu Prasad, Volker Lohmann, Holger Erfle, Berati Cerikan, David L. Paul, Philip V'kovski, Ralf Bartenschlager, Woan-Ing Twu, Volker Thiel, Katrin Hoermann, André C. Mueller, Giulio Superti-Furga, Minh-Tu Pham, Lars Kaderali, Christopher J. Neufeldt
Publikováno v:
Tabata, Keisuke; Prasad, Vibhu; Paul, David; Lee, Ji-Young; Pham, Minh-Tu; Twu, Woan-Ing; Neufeldt, Christopher J; Cortese, Mirko; Cerikan, Berati; Stahl, Yannick; Joecks, Sebastian; Tran, Cong Si; Lüchtenborg, Christian; V'kovski, Philip; Hörmann, Katrin; Müller, André C; Zitzmann, Carolin; Haselmann, Uta; Beneke, Jürgen; Kaderali, Lars; ... (2021). Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation. Nature Communications, 12(1), p. 7276. Springer Nature 10.1038/s41467-021-27511-1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Double membrane vesicles (DMVs) serve as replication organelles of plus-strand RNA viruses such as hepatitis C virus (HCV) and SARS-CoV-2. Viral DMVs are morphologically analogous to DMVs formed during autophagy, but lipids driving their biogenesis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e0eb24bb13730b45a04c281f834aaf
Autor:
Junyan Lu, Rosó Mares, Thorsten Zenz, Anna Enjuanes, Ryan D. Morin, Alfredo Rivas-Delgado, Julio Delgado, Rut Mas-de-les-Valls, Peter J. Campbell, Neus Villamor, Tycho Baumann, Ferran Nadeu, Helena Suárez-Cisneros, Dolors Colomer, Alba Navarro, Elias Campo, Romina Royo, Marta Aymerich, Francesco Maura, Xose S. Puente, Silvia Martín, Sílvia Beà
Publikováno v:
Nature Communications
Scopus
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Scopus
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are routinely assessed during the characterization of B cell neoplasms and stratification of patients with distinct clinical and biological features, with the assessment done using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c68977f2c518bf220857b028aef5db5
https://hdl.handle.net/2117/328399
https://hdl.handle.net/2117/328399
Autor:
Daniel Brigger, Rahel Ruppli, Pascal Guntern, Theodore S. Jardetzky, Alexander Eggel, Svetlana S. Tarchevskaya, Silke Kleinboelting, Noemi Zbären, Pascal Gasser, Christoph Heusser
Publikováno v:
Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Targeting of immunoglobulin E (IgE) represents an interesting approach for the treatment of allergic disorders. A high-affinity monoclonal anti-IgE antibody, ligelizumab, has recently been developed to overcome some of the limitations associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724f87e01b9a61768d0b922f9bc49897
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf
https://boris.unibe.ch/138505/1/s41467-019-13815-w.pdf