Zobrazeno 1 - 10
of 185
pro vyhledávání: ''
Autor:
Nobuhide Higashino, Mari Nishio, Masaki Shimizu, Yoshihiro Kakeji, Masataka Fujikawa, Takayuki Kodama, Hiroki Sakamoto, Hiroshi Yokozaki, Kohei Tanigawa, Manabu Shigeoka, Yu-ichiro Koma
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain u
Autor:
Kaito Shibata, Junichi Kawakami, Satoshi Hirakawa, Hiroyuki Mineta, Seiji Hosokawa, Koji Suzuki, Takafumi Naito
Publikováno v:
Cancer Chemotherapy and Pharmacology. 87(4):555-565
Purpose: Cetuximab inhibits epidermal growth factor receptor (EGFR) signaling in cancer and skin cells, thereby inducing anti-cancer effects and skin disorders. The present study aimed to evaluate the relationships between serum cetuximab and EGFR-re
Autor:
Dirkje W. Sommeijer, Matthew T. Seymour, Lianne Koens, Cornelis J. A. Punt, Sanne ten Hoorn, David Fisher, Tim Maughan, Louis Vermeulen, Faye Elliott, Anne Trinh, Phil Quirke, Susan D. Richman, Jenny F. Seligmann, Tim R. de Back, Richard Adams
Publikováno v:
British Journal of Cancer
British journal of cancer, 125(8), 1080-1088. Nature Publishing Group
British journal of cancer, 125(8), 1080-1088. Nature Publishing Group
Background Patient selection for addition of anti-EGFR therapy to chemotherapy for patients with RAS and BRAF wildtype metastatic colorectal cancer can still be optimised. Here we investigate the effect of anti-EGFR therapy on survival in different c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329765bd38bc4fb86b004b51f8c16428
https://eprints.whiterose.ac.uk/176152/6/s41416-021-01477-9.pdf
https://eprints.whiterose.ac.uk/176152/6/s41416-021-01477-9.pdf
Autor:
Antonio Garcia-Gomez, Laura San-Segundo, Laura Ciudad, Manel Esteller, Xabier Morales, Esteban Ballestar, Javier Rodríguez-Ubreva, Carlos Ortiz-de-Solorzano, Julen Oyarzabal, Felipe Prosper, Mercedes Garayoa, Tianlu Li, Sandra Muntión, Montserrat Martín-Sánchez, Xabier Agirre, Edurne San José-Enériz, Carlos de la Calle-Fabregat, Gerard Godoy-Tena, Francesc Català-Moll
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digital.CSIC. Repositorio Institucional del CSIC
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digital.CSIC. Repositorio Institucional del CSIC
© The Author(s) 2021.
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epige
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe16b4cd0ce50169152c027ce7ca5a9
http://hdl.handle.net/2445/174307
http://hdl.handle.net/2445/174307
Autor:
Vicente Pérez-Brocal, Gabriela Debesa-Tur, Susana Ruiz-Ruiz, Amparo Latorre, Adela Castillejo, Andrés Moya, José Luis Soto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Scientific Reports
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
An increased risk of developing colorectal cancer (CRC) and other types of tumor is associated to Lynch syndrome (LS), an inherited condition caused by germline mutations in mismatch repair genes. We selected a cohort of LS patients that had develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aefdca9cc74574cd565500887f6c988
http://hdl.handle.net/10261/247311
http://hdl.handle.net/10261/247311
Autor:
Fotios Loupakis, Sara Lonardi, Chiara Cremolini, Afsaneh Barzi, Yuji Miyamoto, Shivani Soni, Satoshi Okazaki, Marta Schirripa, Mitsukuni Suenaga, Wu Zhang, Toshiharu Yamaguchi, Shu Cao, Martin D. Berger, Heinz-Josef Lenz, Alfredo Falcone
Colorectal cancer (CRC) can be classified into subtypes based on gene expression signatures. Patients with stage III enterocyte subtype of the CRC Assigner classifier have been shown to benefit from oxaliplatin adjuvant therapy. Here, we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ff7e6de5b6fd5cfca1baeea302a15d
Autor:
Akihiro Nakahata, Sachiko Iwai, Hanako Ohashi Ikeda, Hiroyuki Yoshitomi, Akira Ito, Shuichi Matsuda, Hiroshi Kuroki, Motoo Saito, Shinichiro Nakamura, Shinichi Kuriyama, Koichi Murata, Kohei Nishitani, Akira Kakizuka, Shigeo Yoshida, Tomoki Aoyama, Xiang Ji, Hiromu Ito
Publikováno v:
Scientific Reports
Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the recovery after intra-articular injuries or surgeries. Currently, no effective treatment is available. In this study, we showed that inhibition of the acute stage ch
Autor:
Yuichi Sakamori, Naoki Nakajima, Toyohiro Hirai, Takahiro Tsuji, Akihiko Yoshizawa, Toshi Menju, Hiroaki Ozasa, Hitomi Ajimizu, Hiroshi Date, Hironori Yoshida, Yuto Yasuda, Tomoko Funazo, Masatoshi Yamazoe, Takashi Nomizo, Young Hak Kim
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expre
Autor:
Beatriz Bellosillo, E. Luño, Cristina Martínez, Carlos Besses, J.M. Hernández-Rivas, Valentín García-Gutiérrez, Juan Carlos Hernández-Boluda, Natalia Estrada, Patricia Velez, Ernesto J Cuenca, Francisca Ferrer-Marín, Rosa Ayala, C García Hernandez, Vicente Vicente, Concepción Fernández-Rodríguez, D V Fiallo-Suárez, Rosa Cifuentes, Lurdes Zamora, R. Gonzalez-Conejero, A.M. De Los Reyes-Garcia, M. T. Gomez-Casares, Ana Kerguelen, Concepción Boqué, Ana B. Arroyo, Raúl Teruel-Montoya, Beatriz Arrizabalaga, Isabel Arcas, Alberto Alvarez-Larrán
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Leukemia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Leukemia
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), and remarkably shortens survival. Although JAK2V617F and CALR allele burden are the main transformation risk factors, inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6250465ffa90640689364e4c074012
http://hdl.handle.net/10261/230890
http://hdl.handle.net/10261/230890
Autor:
Elise Klæstad, Signe Opdahl, Monica J. Engstrøm, Elisabeth Wik, Borgny Ytterhus, Anna M. Bofin, Marit Valla
Publikováno v:
Breast Cancer Research and Treatment
Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 copy number change and molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49102c4df90ac263d4c308ee2094e138
https://hdl.handle.net/11250/2672584
https://hdl.handle.net/11250/2672584