Zobrazeno 1 - 10
of 11
pro vyhledávání: ''
Autor:
Rushika C. Wirasinha, Hong Ying Teh, Adam E. Handel, Stephen R. Daley, Benoit Roch, Saulius Žuklys, Stuart H. Orkin, Thomas Barthlott, Jean-Pierre de Villartay, Katrin Hafen, Georg A. Holländer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Thymic T cell development and T cell receptor repertoire selection are dependent on essential molecular cues provided by thymic epithelial cells (TEC). TEC development and function are regulated by their epigenetic landscape, in which the repressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9e2439df69c3a497fbd82be6559f2d
https://doi.org/10.1038/s41467-021-24158-w
https://doi.org/10.1038/s41467-021-24158-w
Autor:
Yohei Kawana, Kei Takahashi, Keizo Kaneko, Shinjiro Kodama, Vladimir V. Kalinichenko, Tetsuya Yamada, Shojiro Sawada, Junta Imai, Yoichiro Asai, Akira Endo, Tomohito Izumi, Kenji Uno, Hideki Katagiri, Junpei Yamamoto, Junhong Gao, Masato Kohata, Hiroto Sugawara, Yasushi Ishigaki
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The liver possesses a high regenerative capacity. Liver regeneration is a compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that a vagus-macrophage-hepatocyte link regulates acute liver re
Autor:
Martina Schifferer, Ludovico Cantuti-Castelvetri, Susanne A. Schneider, Sabina Tahirovic, Andrew P. Lieberman, Jasmin König, Lina Dinkel, Silva Hećimović, Laura Sebastian Monasor, Tatiana Bremova-Ertl, Lea Vidatic, Alessio Colombo, Stephan A. Müller, Stefan F. Lichtenthaler, Michael Strupp, Mikael Simons
Publikováno v:
Nature communications
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Nature Communications 12(1), 1158 (2021). doi:10.1038/s41467-021-21428-5
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Colombo, Alessio; Dinkel, Lina; Müller, Stephan A; Sebastian Monasor, Laura; Schifferer, Martina; Cantuti-Castelvetri, Ludovico; König, Jasmin; Vidatic, Lea; Bremova-Ertl, Tatiana; Lieberman, Andrew P; Hecimovic, Silva; Simons, Mikael; Lichtenthaler, Stefan F; Strupp, Michael; Schneider, Susanne A; Tahirovic, Sabina (2021). Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications, 12(1), p. 1158. Springer Nature 10.1038/s41467-021-21428-5
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f3dd22cdadfd9d9d515dc2698deab
http://fulir.irb.hr/6941/
http://fulir.irb.hr/6941/
Autor:
Jianhua Li, Sebastian A. Leidel, Kenjiro Adachi, Karina Mildner, Rui Fan, Dagmar Zeuschner, Jie Wu, Yung Su Kim, Hans R. Schöler, Rui Chen, Styliani Galatidou, Guangming Wu, Ivan Bedzhov
Publikováno v:
Fan, Rui; Kim, Yung Su; Wu, Jie; Chen, Rui; Zeuschner, Dagmar; Mildner, Karina; Adachi, Kenjiro; Wu, Guangming; Galatidou, Styliani; Li, Jianhua; Schöler, Hans R.; Leidel, Sebastian A.; Bedzhov, Ivan (2020). Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nature Communications, 11(1) Springer Nature 10.1038/s41467-020-19353-0
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The epiblast, which provides the foundation of the future body, is actively reshaped during early embryogenesis, but the reshaping mechanisms are poorly understood. Here, using a 3D in vitro model of early epiblast development, we identify the canoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c7d65da8a54a7621a5f7a7ab5e2651
https://boris.unibe.ch/151555/1/s41467-020-19353-0.pdf
https://boris.unibe.ch/151555/1/s41467-020-19353-0.pdf
Autor:
Lamberto Maffei, M. Panniello, Silvia Landi, Maria Spolidoro, Sabrina Chierzi, L. De Vivo, Tommaso Pizzorusso, Letizia Mariotti, Laura Baroncelli, Gian Michele Ratto
Publikováno v:
Nature Communications
Nature Communications; Vol 4
Nature communications (2013). doi:10.1038/ncomms2491
info:cnr-pdr/source/autori:De Vivo L.; Landi S.; Panniello M.; Baroncelli L.; Chierzi S.; Mariotti L.; Spolidoro M.; Pizzorusso T.; Maffei L.; Ratto GM./titolo:Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex/doi:10.1038%2Fncomms2491/rivista:Nature communications/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume
Nature Communications; Vol 4
Nature communications (2013). doi:10.1038/ncomms2491
info:cnr-pdr/source/autori:De Vivo L.; Landi S.; Panniello M.; Baroncelli L.; Chierzi S.; Mariotti L.; Spolidoro M.; Pizzorusso T.; Maffei L.; Ratto GM./titolo:Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex/doi:10.1038%2Fncomms2491/rivista:Nature communications/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume
Brain cells are immersed in a complex structure forming the extracellular matrix. The com- position of the matrix gradually matures during postnatal development, as the brain circuitry reaches its adult form. The fully developed extracellular environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b360bc6cffa8f053d8e442d7e2b165ec
https://doi.org/10.1038/ncomms2491
https://doi.org/10.1038/ncomms2491
Autor:
Norbert Leitinger, Jian Sun, Tammy H. Cummings, Siddharth Narendran, James W. Hardin, Christian Röver, Nagaraj Kerur, Hannah Leung, Dongxu Fu, Chris Andrews, Bradley D. Gelfand, Felipe Pereira, S Scott Sutton, Joshua D. Stein, Shuichiro Hirahara, Charles L. Bennett, Joseph Magagnoli, Jayakrishna Ambati, Srabani Sahu, Kameshwari Ambati, Babatunde Edun, Shinichi Fukuda, Akshat Pandey, Akhil Varshney, Benjamin J. Fowler, Lekha Pandya, Meenakshi Ambati, Shaobin Wang, Brian C. Werner
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs
Autor:
Hironori Haga, Hirofumi Shibata, Bunya Kuze, Mio Kabata, Shingo Komura, Takuya Yamamoto, Akito Tanaka, Nao Sankoda, Yosuke Yamada, Satoko Sakurai, Knut Woltjen, Tomoyo Ukai, Yoshiya Kawaguchi, Yasuhiro Yamada, Yatsuji Ito
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
The faithful shutdown of the somatic program occurs in the early stage of reprogramming. Here, we examined the effect of in vivo reprogramming on Kras-induced cancer development. We show that the transient expression of reprogramming factors (1–3 d
Autor:
Maximilian Kleinert, Josefine Reber, Tim Gruber, Emmani B.M. Nascimento, Timo D. Müller, Stephan Sachs, Patrick Schrauwen, Martin Jastroch, Susanna M. Hofmann, Brian Finan, Vasilis Ntziachristos, Christoffer Clemmensen, Matthias H. Tschöp, Gerald Grandl, Annette Feuchtinger, Michael A. Cowley, Carmelo Quarta, Stephanie E. Simonds, Sigrid Jall, Angelos Karlas, Susanne Keipert, Daniela Loher, Eva Sanchez-Quant, Katrin Fischer
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Clemmensen, C, Jall, S, Kleinert, M, Quarta, C, Gruber, T, Reber, J, Sachs, S, Fischer, K, Feuchtinger, A, Karlas, A, Simonds, S E, Grandl, G, Loher, D, Sanchez-Quant, E, Keipert, S, Jastroch, M, Hofmann, S M, Nascimento, E B M, Schrauwen, P, Ntziachristos, V, Cowley, M A, Finan, B, Müller, T D & Tschöp, M H 2018, ' Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes ', Nature Communications, vol. 9, 4304 . https://doi.org/10.1038/s41467-018-06769-y
Nature Communications, 9:4304. Nature Publishing Group
Nat. Commun. 9:4304 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Clemmensen, C, Jall, S, Kleinert, M, Quarta, C, Gruber, T, Reber, J, Sachs, S, Fischer, K, Feuchtinger, A, Karlas, A, Simonds, S E, Grandl, G, Loher, D, Sanchez-Quant, E, Keipert, S, Jastroch, M, Hofmann, S M, Nascimento, E B M, Schrauwen, P, Ntziachristos, V, Cowley, M A, Finan, B, Müller, T D & Tschöp, M H 2018, ' Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes ', Nature Communications, vol. 9, 4304 . https://doi.org/10.1038/s41467-018-06769-y
Nature Communications, 9:4304. Nature Publishing Group
Nat. Commun. 9:4304 (2018)
Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101ff71e3282c5fe6bf40d3b607f7b73
https://mediatum.ub.tum.de/doc/1510435/document.pdf
https://mediatum.ub.tum.de/doc/1510435/document.pdf
Autor:
Javier Rangel-Moreno, Shabaana A. Khader, Kristin L. Griffiths, Maxim N. Artyomov, Terry D. Connell, Mushtaq Ahmed, Shibali Das, Jay K. Kolls, Kelly D. Moynihan, William Horne, Radha Gopal, Darrell J. Irvine
Publikováno v:
Nature
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039a941640f2f8f9ece4994982f1a14
http://hdl.handle.net/1721.1/107719
http://hdl.handle.net/1721.1/107719
Autor:
Jonathan T. Eggenschwiler, Cullen Timmons, Jie Li, Andrew T. Sornborger, Yousuke Takahama, Floria I. Lupu, Nancy R. Manley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present