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Autor:
Miguel Muñoz, José A. Pérez-Simón, Estefanía García-Guerrero, P. Trujillo-Hacha, A. Molinos-Quintana, Jose Antonio Bejarano-García, José I. Piruat
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The substance P/neurokinin-1 receptor system has been implicated in tumor cell proliferation. Neurokinin-1 receptor has been identified in different solid tumors but not frequently in hematopoietic malignant cells. We investigated the presence of the
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Background and Objectives Previous pharmacokinetic studies of the inhaled corticosteroid, fluticasone furoate (FF), and the long-acting, beta2-receptor agonist, vilanterol (VI) have been performed in relatively small populations using non-compartment
Autor:
Paulina Koczurkiewicz, Marcin Kołaczkowski, Adam Bucki, Elżbieta Pękala, Kamil Piska, Katarzyna Wójcik-Pszczoła
Publikováno v:
Investigational New Drugs
SummaryAnthracycline antibiotics (ANT), such as doxorubicin or daunorubicin, are a class of anticancer drugs that are widely used in oncology. Although highly effective in cancer therapy, their usefulness is greatly limited by their cardiotoxicity. P
Autor:
Mirella Falconi, Mitch A. Phelps, Gabriella Teti, Jiang Wang, Timothy P. Cripe, Mark A. Currier, Isabella Orienti
Publikováno v:
Pharmaceutical Research
Purpose We describe a novel class of antitumor amphiphilic amines (RCn) based on a tricyclic amine hydrophilic head and a hydrophobic linear alkyl tail of variable length. Methods We tested the lead compound, RC16, for cytotoxicity and mechanism of c
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Recurrent, chemo-resistant ovarian cancer is thought to be due to a subgroup of slow-growing, drug-resistant cancer cells with stem-like properties and a high capacity for tumour repair. Cantrixil targets this sub-population of cells and is b
Autor:
Manuela Licata, Federica Palazzoli, Enrico Silingardi, Anna Ferrari, Daniele Vandelli, Carlo Baraldi, Patrizia Verri, Cecilia Rustichelli, Filippo Marchesi
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The aim of this study was to evaluate the potential of hair analysis to monitor medication adherence in headache patients undergoing chronic therapy. For this purpose, the following parameters were analyzed: the detection rate of 23 therapeut
Publikováno v:
CNS Drugs
Patients with major depression often report pain. In this article, we review the current literature regarding the prevalence and consequences, as well as the pathophysiology, of unexplained painful physical symptoms (UPPS) in patients with major depr
Autor:
E. Brendel, Matthias Ludwig, Caroline Robert, Chetan Lathia, Jean-Charles Soria, Stanislas Ropert, Jean-Pierre Armand
Publikováno v:
Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2010, 68 (1), pp.53-61. 〈10.1007/s00280-010-1423-9〉
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2010, 68 (1), pp.53-61. ⟨10.1007/s00280-010-1423-9⟩
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2010, 68 (1), pp.53-61. 〈10.1007/s00280-010-1423-9〉
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2010, 68 (1), pp.53-61. ⟨10.1007/s00280-010-1423-9⟩
Purpose Sorafenib, a multikinase inhibitor of Raf and several growth factor receptors, is under investigation in combination with dacarbazine, a commonly used chemotherapeutic agent for the treatment of many cancers. The current phase I study investi
Autor:
Irini C. Voudouragkaki, Paraskevas V Kapis, Konstantinos Marinopoulos, Dimitrios G. Mikropoulos, Luciano Quaranta, Anastasios-Georgios Konstas, Konstadinos G. Boboridis, Eirini Pagkalidou, Andreas Katsanos, Anna-Bettina Haidich, Dimitrios Panayiotou
Publikováno v:
Advances in Therapy
The aim of the present study was to evaluate the 24-h efficacy, tolerability, and ocular surface health with preservative-free (PF) tafluprost and a PF triple drug regimen comprising tafluprost and dorzolamide/timolol fixed combination (DTFC) in open
Autor:
Joost P.H. Drenth, David M. Burger, Elise J. Smolders, Bart van Hoek, Joop E. Arends, Clara T. M. M. de Kanter
Publikováno v:
Drug Safety
Drug Safety, 39, 7, pp. 589-611
Drug Safety, 39(7), 589. Adis International Ltd
Drug Safety, 39, 589-611
Drug Safety, 39, 7, pp. 589-611
Drug Safety, 39(7), 589. Adis International Ltd
Drug Safety, 39, 589-611
Contains fulltext : 171181.pdf (Publisher’s version ) (Open Access) Hepatitis C virus (HCV)-infected patients often suffer from liver cirrhosis, which can be complicated by renal impairment. Therefore, in this review we describe the treatment possi