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Autor:
Nobuhide Higashino, Mari Nishio, Masaki Shimizu, Yoshihiro Kakeji, Masataka Fujikawa, Takayuki Kodama, Hiroki Sakamoto, Hiroshi Yokozaki, Kohei Tanigawa, Manabu Shigeoka, Yu-ichiro Koma
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain u
Autor:
Yuichi Sakamori, Naoki Nakajima, Toyohiro Hirai, Takahiro Tsuji, Akihiko Yoshizawa, Toshi Menju, Hiroaki Ozasa, Hitomi Ajimizu, Hiroshi Date, Hironori Yoshida, Yuto Yasuda, Tomoko Funazo, Masatoshi Yamazoe, Takashi Nomizo, Young Hak Kim
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 3, Pp 1-15 (2020)
There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expre
Autor:
J H-S Lee, T K-H Chung, T-H Cheung, L K-Y Chan, C S-Y Yeung, T-S Lau, S-F Yim, E C-H Wong, C W-C Hui, Joseph Kwong, K Sneddon
Publikováno v:
Oncogene
Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f1a686d978e5ae72168682f39a0f5f
Autor:
Malgorzata Jarmuz-Szymczak, Magdalena Bodnar, Kinga Bednarek, Magdalena Luczak, Reidar Grénman, Andrzej Marszałek, Lukasz Szylberg, Maciej Giefing, Krzysztof Szyfter
Publikováno v:
Amino Acids
Relapse and metastasis are the main causes of unfavorable outcome in head and neck cancers. Whereas, understanding of the molecular background of these processes is far from being complete. Therefore, in this study we aimed to identify potential biom
Publikováno v:
Tumour Biology
Long noncoding RNA 19 (H19) has been shown to promote bladder cancer cell proliferation and metastasis. However, little is known about how miR-675, mature product of H19, contributes to bladder cancer cell proliferation. In this study, we first evalu
Autor:
Yen Sung Huang, Gu-Jiun Lin, Yuan-Wu Chen, Shing-Hwa Huang, Hsiu Ming Shih, Chih-Kung Lin, Huey-Kang Sytwu
Publikováno v:
Clinical Oral Investigations
Objectives Death domain-associated protein (Daxx) has been recently implicated as a positive factor in ovarian cancer and prostate cancer, but the role of Daxx in oral squamous cell carcinoma (OSCC) has never been addressed. Herein, we investigate th
Publikováno v:
Tumour Biology
Primary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but
Autor:
Xuan Pu, Stewart G. Martin, Emad A. Rakha, Andrew R. Green, Yimin Zhang, Ian O. Ellis, Sarah J. Storr
Publikováno v:
Apoptosis
Impaired apoptosis is one of the hallmarks of cancer. Caspase-3 and -8 are key regulators of the apoptotic response and have been shown to interact with the calpain family, a group of cysteine proteases, during tumorigenesis. The current study sought
Autor:
Rossella Marullo, Rebecca Elstrom, Shao-Ning Yang, Haelee Ahn, Richard R. Furman, John P. Leonard, Leandro Cerchietti, Benet Pera, Jayeshkumar Patel, Jia Ruan, Peter Martin, Tiffany Tang
Publikováno v:
Clinical Epigenetics
Background Refractory and/or relapsed diffuse large B cell lymphoma (RR-DLBCL) patients are incurable with conventional chemotherapy due to the aggressiveness and the chemorefractory state of these tumors. DNA hypermethylation and histone deacetylati
Publikováno v:
BMC Cancer
Background The receptor for advanced glycation endproducts (RAGE) and microvascular status both play a critical role in cancer progression. However, the crosstalk between RAGE and microvascular formation in endometrial cancer remains largely unknown.