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pro vyhledávání: '"Kevin J Harrington"'
Publikováno v:
Critical Issues in Head and Neck Oncology ISBN: 9783031231742
Until recently, radiotherapy was viewed solely from a tumour cell-autonomous perspective, whereby successful therapy resulted from inflicting breaks in nuclear DNA above an unspecified threshold that exceeded the tumour cell’s capacity for repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc55a8b2c4f66de927e82ac2b696c550
https://doi.org/10.1007/978-3-031-23175-9_3
https://doi.org/10.1007/978-3-031-23175-9_3
Autor:
Kevin J. Harrington
Publikováno v:
Critical Issues in Head and Neck Oncology ISBN: 9783030632335
Despite significant technical improvements in the management of patients with locoregionally-advanced head and neck cancers, too many patients fail to achieve durable remissions that ultimately translate into cures. Loco-regional recurrence and/or me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b374f2218f3cd148c729b8db8794311
https://doi.org/10.1007/978-3-030-63234-2_14
https://doi.org/10.1007/978-3-030-63234-2_14
Autor:
Kevin J. Harrington
Publikováno v:
Critical Issues in Head and Neck Oncology ISBN: 9783319988535
Homologous recombination repair (HRR) is a normal cellular process by which spontaneous (endogenous) and exogenous DNA damage is corrected and, as such, it is essential to maintenance of normal tissue homeostasis. HRR function is very frequently disr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1cb9a218665b0def0383d67afdaa0a
https://doi.org/10.1007/978-3-319-98854-2_5
https://doi.org/10.1007/978-3-319-98854-2_5
Autor:
Kevin J. Harrington, Magnus T. Dillon
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9783319758343
ATR inhibitors are a new class of anti-cancer compounds reaching early phase clinical trials. They are predicted to have anti-cancer activity as monotherapy, and in combination with DNA damaging chemotherapies and ionizing radiation. We outline the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3bd20e7a51b3529ba9dac0a50870440
https://doi.org/10.1007/978-3-319-75836-7_5
https://doi.org/10.1007/978-3-319-75836-7_5
Autor:
Kevin J. Harrington
Publikováno v:
Critical Issues in Head and Neck Oncology ISBN: 9783319429076
Cancer is a genetic disease that arises when the information in cellular DNA is corrupted, leading to abnormal patterns of gene expression. As a result, the effects of normal genes that control normal cellular functions, such as growth, survival and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc10ee92579245ba36398d0b6a2b6648
https://doi.org/10.1007/978-3-319-42909-0_3
https://doi.org/10.1007/978-3-319-42909-0_3