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Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
BACKGROUND AND OBJECTIVE: Vancomycin is often used in the ICU for the treatment of Gram-positive bacterial infection. In critically ill children, there are pathophysiologic changes that affect the pharmacokinetics of vancomycin. A systematic review o
Autor:
Margherita Bennetts, Michael Moran, Maik Häntschel, Julia Brinkmann, Kato Kambartel, Barbara Melosky, Federico Cappuzzo, Antonin Kayser, Dana J. Nickens
Publikováno v:
Molecular Diagnosis & Therapy
Background Identification of variable epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer (NSCLC) is important for the selection of appropriate targeted therapies. This meta-analysis was conducted to provide a worldwi
Publikováno v:
International Journal of Clinical Pharmacy
Background Previous reports about risk factors for linezolid-induced thrombocytopenia have been insufficient, often due to the variability in study design and population, and some factors have not yet been studied. Aim The aims of this study are to d
Autor:
Barry Koplowitz, Wei H. Yang, Robert Jordan, Keith Barnett, John Dodd, Luana Pesco Koplowitz, Marie Makhlina, Carl Spana
Publikováno v:
Drugs in R&D
Background and Objective PL8177 is a selective melanocortin 1 receptor agonist in development for the treatment of various immunologic and inflammatory conditions. Here we describe the pharmacokinetics of PL8177 after subcutaneous (sc) delivery in an
Autor:
Yuki Isogai, Miki Ishida, Fumihiko Sakai, Chiharu Usuki, Norihiro Suzuki, Xiaoping Ning, Nobuyuki Koga, Katsuhiro Iba
Publikováno v:
Drug Safety
Introduction Early discontinuation and poor adherence are common limitations of conventional preventive migraine medications that limit their long-term efficacy. Therefore, a migraine preventive medication with favorable long-term safety is warranted
Publikováno v:
Inflammopharmacology
Background Malnutrition is seen in COVID-19 patients, and reducing malnutrition with appropriate therapies may improve these patients' health. This case–control study aimed to assess and compare serum levels of some inflammatory factors, oxidative
Publikováno v:
Drugs in R&D
Background and Objective Intravenous (IV) belimumab is the first treatment approved for children ≥5 years of age with active autoantibody-positive systemic lupus erythematosus (SLE) in the USA, Europe, and Japan. Pharmacokinetic data for belimumab
Autor:
Nripen Chanda, Nanne K. H. de Boer, Femke Crouwel, Chris J. J. Mulder, Timothy H. Florin, Ahmed B. Bayoumy, Hans J. C. Buiter
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Bayoumy, A B, Crouwel, F, Chanda, N, Florin, T H J, Buiter, H J C, Mulder, C J J & de Boer, N K H 2021, ' Advances in Thiopurine Drug Delivery: The Current State-of-the-Art ', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 6, pp. 743-758 . https://doi.org/10.1007/s13318-021-00716-x
Bayoumy, A B, Crouwel, F, Chanda, N, Florin, T H J, Buiter, H J C, Mulder, C J J & de Boer, N K H 2021, ' Advances in Thiopurine Drug Delivery: The Current State-of-the-Art ', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 6, pp. 743-758 . https://doi.org/10.1007/s13318-021-00716-x
Thiopurines (mercaptopurine, azathioprine and thioguanine) are well-established maintenance treatments for a wide range of diseases such as leukemia, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE) and other inflammatory and auto