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Autor:
Alireza Soltani, Etienne Koechlin
Publikováno v:
Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, In press, ⟨10.1038/s41386-021-01123-1⟩
Neuropsychopharmacology, Nature Publishing Group, In press, ⟨10.1038/s41386-021-01123-1⟩
The real world is uncertain, and while ever changing, it constantly presents itself in terms of new sets of behavioral options. To attain the flexibility required to tackle these challenges successfully, most mammalian brains are equipped with certai
Publikováno v:
Neuropsychopharmacology
Synaptic dysfunction is a likely proximate cause of subtle cognitive impairment in early Alzheimer’s disease. Soluble oligomers are the most synaptotoxic forms of amyloid ß-protein (Aß) and mediate synaptic plasticity disruption in Alzheimer’s
Autor:
Paolo E. Forni, Raghu Ram Katreddi
Publikováno v:
Cellular and Molecular Life Sciences
The vomeronasal organ (VNO) is sensory organ located in the ventral region of the nasal cavity in rodents. The VNO develops from the olfactory placode during the secondary invagination of olfactory pit. The embryonic vomeronasal structure appears as
Autor:
Patryk Konieczny, Alicja Starosta
Publikováno v:
Cellular and Molecular Life Sciences
Duchenne muscular dystrophy (DMD) is a devastating chromosome X-linked disease that manifests predominantly in progressive skeletal muscle wasting and dysfunctions in the heart and diaphragm. Approximately 1/5000 boys and 1/50,000,000 girls suffer fr
Publikováno v:
Cellular and Molecular Life Sciences
Punovuori, K, Malaguti, M & Lowell, S 2021, ' Cadherins in early neural development ', Cellular and Molecular Life Sciences . https://doi.org/10.1007/s00018-021-03815-9
Punovuori, K, Malaguti, M & Lowell, S 2021, ' Cadherins in early neural development ', Cellular and Molecular Life Sciences . https://doi.org/10.1007/s00018-021-03815-9
During early neural development, changes in signalling inform the expression of transcription factors that in turn instruct changes in cell identity. At the same time, switches in adhesion molecule expression result in cellular rearrangements that de
Autor:
Bilal Ashraf, Daniel Lawson
Publikováno v:
European Journal of Human Genetics
European Journal of Human Genetics, 2021, Vol.29(10), pp.1549-1556 [Peer Reviewed Journal]
European Journal of Human Genetics, 2021, Vol.29(10), pp.1549-1556 [Peer Reviewed Journal]
Most complex traits evolved in the ancestors of all modern humans and have been under negative or balancing selection to maintain the distribution of phenotypes observed today. Yet all large studies mapping genomes to complex traits occur in populati
Autor:
Josefina Felisart, Agustí Camps, Iago Maceda, Sergi Beltran, Miguel Martín Álvarez, Georgios Athanasiadis, Pedro Moral, José Luis Remón, Jordi Fàbrega, Raul Tonda, Oscar Lao, Jordi Camps, Joan Grané, Jordi Serra
Publikováno v:
European Journal of Human Genetics
The area of the Spanish Pyrenees is particularly interesting for studying the demographic dynamics of European rural areas given its orography, the main traditional rural condition of its population and the reported higher patterns of consanguinity o
Autor:
Cenna Doornbos, Ronald Roepman
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 78, 11, pp. 4955-72
Cellular and Molecular Life Sciences, 78, 4955-72
Cellular and Molecular Life Sciences, 78, 11, pp. 4955-72
Cellular and Molecular Life Sciences, 78, 4955-72
Correct timing of cellular processes is essential during embryological development and to maintain the balance between healthy proliferation and tumour formation. Assembly and disassembly of the primary cilium, the cell’s sensory signalling organel
Publikováno v:
Neuropsychopharmacology
Chronic stress is a risk factor for a variety of psychiatric disorders, including depression. Although impairments to motivated behavior are a major symptom of clinical depression, little is known about the circuit mechanisms through which stress imp
Autor:
Alba Roca-Portoles, Stephen W.G. Tait
Publikováno v:
Cellular and Molecular Life Sciences
Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial health, various processes co-operate at both the molecular and organelle level. At the molecular level, mitochondria can sense imbalances in their homeostasis