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Publikováno v:
Human Genetics
Hemophilia is caused by various mutations in blood coagulation factor genes, including factor VIII (FVIII) and factor IX (FIX), that encode key proteins in the blood clotting pathway. Although the addition of therapeutic genes or infusion of clotting
Autor:
Franziska Hartung, Luis A. Pardo
Publikováno v:
European Biophysics Journal
Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strategy using Kv10.1 as a target. Kv10.1 is a
Autor:
Felix Lötsch, Klaus Kaczirek, Fredrik Waneck, Herbert Auer, Judith Naderer, Mirjam Groger, Tomislava Skuhala, Michael Ramharter
Publikováno v:
Parasitology Research
Cystic echinococcosis (CE) is a widespread zoonosis caused by the species complex Echinococcus granulosus. Albendazole (ABZ)—the first-line anthelminthic drug for medical treatment of CE—is metabolized in vivo to the active derivative ABZ-sulphox
Autor:
Waleria Hryniewicz, Ewa Sadowy, Katarzyna Bojarska, Iwona Gawryszewska, D. Żabicka, K. Malinowska
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
The aim of this study was to investigate human invasive isolates of enterococci, obtained through prospective surveillance in Poland. The consecutive enterococcal isolates were collected in 30 hospitals between May 2010 and June 2011, and studied by
Autor:
Gerd A. Kullak-Ublick, Christoph Gubler, Katharina Spanaus, Alexander Jetter, Manfred G. Ismair, Tatiana Claro da Silva
Publikováno v:
European Journal of Clinical Pharmacology
Eur J Clin Pharmacol
Eur J Clin Pharmacol
Purpose In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein expression of the transporter OAT
Publikováno v:
Analytical and Bioanalytical Chemistry
Seeds of plants from Ipomoea genera contain numerous ergot alkaloids, including psychoactive ergine and ergometrine, and are often abused as so-called “legal highs.” In this work, an analytical method for determination of ergine and ergometrine,
Autor:
Bengt Sjögren, Eva Andersson, Karine Elihn, Lennart Andersson, Bodil Persson, Håkan Westberg, Cathe Karlsson, Ing Liss Bryngelsson
Publikováno v:
International Archives of Occupational and Environmental Health
To study the relationship between exposure to airborne particles in a pulp and paper mill and markers of inflammation and coagulation in blood. Personal sampling of inhalable dust was performed for 72 subjects working in a Swedish pulp and paper mill
Publikováno v:
Histochemistry and Cell Biology
We gratefully acknowledge financial support from the Wellcome Trust (Grant No. WT089803MA to J.M.L.) and the School of Medicine, University of St Andrews. Neurite growth is central to the formation and differentiation of functional neurons and recent
Autor:
Gary R. Matyas, Carl R. Alving, Rashmi Jalah, Fuying Li, Arthur E. Jacobson, Oscar B. Torres, Joshua F. G. Antoline, Kenner C. Rice
Publikováno v:
Analytical and Bioanalytical Chemistry
The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a challenging task. A simple nonradioactive method that uses deuterium-labeled drug tracers and equilib
Autor:
Myrna Virreira, Nicolas Markadieu, Abdullah Sener, Philippe Golstein, Alain Boom, Raphaël Crutzen, Willy Malaisse, Vadim Shlyonsky, Renaud Beauwens
Publikováno v:
Pflugers Archiv
Pflügers Archiv, 468 (4
Pflügers Archiv
Pflügers Archiv, 468 (4
Pflügers Archiv
Anions such as Cl− and HCO3 − are well known to play an important role in glucose-stimulated insulin secretion (GSIS). In this study, we demonstrate that glucose-induced Cl− efflux from β-cells is mediated by the Ca2+-activated Cl− channel a