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Autor:
Hans-Ulrich Humpf, Melanie Esselen, Yannick Hövelmann, Florian Hübner, Jens Köhler, Alexa Zielinski, Annika Jagels
Publikováno v:
Mycotoxin Research
In the course of gaining new insights into the secondary metabolite profile of various Stachybotrys strains, in particular concerning triprenyl phenol-like compounds, so far, unknown metabolites with analogous structural features were discovered. Thr
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology
Purpose The current treatment approaches for Coats’ disease by intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents (ranibizumab or conbercept) combined with laser therapy were evaluated for the efficacy during the treatm
Publikováno v:
Parasitology Research
The objective of this study was to investigate the main clinical signs and symptoms of toxocarosis in children and the treatment results. The study group consisted of 66 seropositive children aged 2 to 16 years, evaluated in an outpatient clinic in n
Publikováno v:
European Journal of Clinical Pharmacology
Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs including isoniazid. We investigated the effect of genotype, geographical difference, and smoking habit on NAT2 phenotype in Ethiopians. Methods Genotyping for NAT2 191G
Autor:
Klaus Schmierer, Francesca Ammoscato, Helen Lock, David Baker, Zhifeng Mao, Bryan Ceronie, Hilary Longhurst, Benjamin Meir Jacobs, Nicolas Dubuisson, Gavin Giovannoni
Publikováno v:
Journal of Neurology
Background The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. Objective To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-mod
Autor:
Happiness Kumburu, Frank Møller Aarestrup, Gibson S. Kibiki, Michael Alifrangis, Marco van Zwetselaar, Blandina T. Mmbaga, Tolbert Sonda, Ole Lund
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
Sonda, T, Kumburu, H, van Zwetselaar, M, Alifrangis, M, Mmbaga, B T, Lund, O, Aarestrup, F M & Kibiki, G 2018, ' Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania ', European Journal of Clinical Microbiology and Infectious Diseases, vol. 37, no. 5, pp. 897-906 . https://doi.org/10.1007/s10096-018-3196-8
Sonda, T, Kumburu, H, van Zwetselaar, M, Alifrangis, M, Mmbaga, B T, Lund, O, Møller Aarestrup, F & Kibiki, G 2018, ' Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania ', European Journal of Clinical Microbiology and Infectious Diseases, vol. 37, no. 5, pp. 897-906 . https://doi.org/10.1007/s10096-018-3196-8
Sonda, T, Kumburu, H, van Zwetselaar, M, Alifrangis, M, Mmbaga, B T, Lund, O, Aarestrup, F M & Kibiki, G 2018, ' Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania ', European Journal of Clinical Microbiology and Infectious Diseases, vol. 37, no. 5, pp. 897-906 . https://doi.org/10.1007/s10096-018-3196-8
Sonda, T, Kumburu, H, van Zwetselaar, M, Alifrangis, M, Mmbaga, B T, Lund, O, Møller Aarestrup, F & Kibiki, G 2018, ' Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania ', European Journal of Clinical Microbiology and Infectious Diseases, vol. 37, no. 5, pp. 897-906 . https://doi.org/10.1007/s10096-018-3196-8
Emergence and spread of extended spectrum beta-lactamase (ESBL)-producing gram-negative bacteria, mainly due to CTX-M, is a major global public health problem. Patients infected with ESBL-producing gram-negative bacteria have an increased risk of tre
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine tra
Autor:
Hiroaki Masuzaki, Masayuki Matsushita, Masato Tsutsui, Keiko Abe, Tadashi Kaname, Chisayo Kozuka, Chitoshi Takayama, Chigusa Shimizu-Okabe
Publikováno v:
Diabetologia
Aims/hypothesis Overeating of dietary fats causes obesity in humans and rodents. Recent studies in humans and rodents have demonstrated that addiction to fats shares a common mechanism with addiction to alcohol, nicotine and narcotics in terms of a d
The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation
Autor:
Erik Renström, Nikolina Papac-Milicevic, Anna M. Blom, Gunilla T. Westermark, Ben C. King, Klaudia Kulak
Publikováno v:
Diabetologia
Aims/hypothesis Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigg
Autor:
Mitsuyoshi Utsugi, Reiko Sakurai, Noriaki Sunaga, Akira Mogi, Yoshio Tomizawa, Tomohito Kuwako, Tomomi Masuda, T. Ishizuka, Kyoichi Kaira, Atsushi Takise, Yosuke Miura, Ryusei Saito, Kimihiro Shimizu, Kaori Seki, Koichi Minato, Masanobu Yamada, Hisao Imai, Shinichi Ishihara, Takeshi Hisada
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose In patients with epidermal growth factor receptor (EGFR)-mutated, advanced, non-small cell lung cancer (NSCLC), common gefitinib-sensitive EGFR mutations that predict a greater response to therapy include the exon 19 deletion and L858R point