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Publikováno v:
Pflugers Archiv
Prostacyclin, or PGI2, is a product of PGI synthase (PGIS), down-stream of cyclooxygenase pathway. PGI2 has been demonstrated to play an important role in maintaining renal blood flow. Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclo
Autor:
Ralf Gold, Aiden Haghikia, Maren Peschke, Gisa Ellrichmann, Kerstin Hellwig, De-Hyung Lee, Jan Bolz, Alexander Duscha, Ralf A. Linker
Publikováno v:
Journal of Neurology
Background With ocrelizumab another drug is available for the treatment of multiple sclerosis (MS). Little is known on the long-term use of ocrelizumab on immune cell subsets, and no surrogate markers are available. Rituximab (RTX) has been in off-la
Autor:
Rodrigo Correa-Oliveira, David I. Pritchard, Jeffrey M. Bethony, Maria Elena Bottazzi, David Diemert, John M. Hawdon
In this chapter, we describe the scientific, technical, clinical and regulatory aspects of establishing a controlled human hookworm infection (CHHI) model in non-endemic and endemic geographical regions, to facilitate a pathway towards accelerated va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede959308c5f047fe8cf1bca637b7831
https://doi.org/10.1007/82_2021_237
https://doi.org/10.1007/82_2021_237
Autor:
Krishika Sambyal, Rahul Vikram Singh
Publikováno v:
Journal of Genetic Engineering & Biotechnology
Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-11 (2020)
Journal of Genetic Engineering and Biotechnology, Vol 18, Iss 1, Pp 1-11 (2020)
Background Ascomycin is a highly valuable multifunctional drug which exhibits numerous biological properties. Being an immunosuppressant, it is known to prevent graft rejection in humans and has potential to treat varying skin ailments. Its derivativ
Autor:
Masashi Kato, Hiromitsu Suzuki, Motoyuki Shimizu, Hisashi Kajimura, Seitaro Tsutsumi, Yoshihito Suzuki, Yuto Kawai, Sho Tsuzuki, Aya Yamaguchi, Kiyota Sakai, Sadanari Jindou
Publikováno v:
AMB Express
AMB Express, Vol 10, Iss 1, Pp 1-13 (2020)
AMB Express, Vol 10, Iss 1, Pp 1-13 (2020)
Despite the threat of Fusarium dieback posed due to ambrosia fungi cultured by ambrosia beetles such as Euwallacea spp., the wood-degradation mechanisms utilized by ambrosia fungi are not fully understood. In this study, we analyzed the 16S rRNA and
Autor:
David Smith, Frank W. Lewis, Joanna L. Elson, David Tetard, Ilse S. Pienaar, Véronique Hubscher-Bruder, David T. Dexter, Safiya Fairooz, Jérémy Brandel, Meera Soundararajan
Publikováno v:
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02672-y⟩
Archives of Toxicology, Springer Verlag, 2020, ⟨10.1007/s00204-020-02672-y⟩
Ubiquitin proteasome system (UPS) impairment, excessive cellular oxidative stress, and iron dyshomeostasis are key to substantia nigra dopaminergic neuronal degeneration in Parkinson's disease (PD); however, a link between these features remains unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0753df8db8fd0462fcecf77f14fd15
https://shura.shu.ac.uk/26416/1/204_2020_Article_2672.pdf
https://shura.shu.ac.uk/26416/1/204_2020_Article_2672.pdf
Publikováno v:
AMB Express
AMB Express, Vol 10, Iss 1, Pp 1-10 (2020)
AMB Express, Vol 10, Iss 1, Pp 1-10 (2020)
Two novel glycoside hydrolases were cloned from the genomic DNA of alklinphilic bacterium Cellulomonas bogoriensis 69B4T and functionally expressed in Escherichia coli. The two enzymes shared less than 73% of identities with other known glycosidases
Infection of host cells by mammalian reovirus in culture or in tissues of infected animals results in cell death. Cell death of infected neurons and myocytes contributes to the pathogenesis of reovirus-induced encephalitis and myocarditis in a newbor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::891faae26d86839fa144fcc5fec1be92
https://doi.org/10.1007/82_2020_225
https://doi.org/10.1007/82_2020_225
Publikováno v:
Essentials of Diagnostic Pathology ISBN: 9783662603079
The normal red blood cell count is kept by the balance between erythrocyte production and erythrocyte destruction. The regulation of progenitor cells to the erythroid lineage and their maturation are controlled by growth factors, cytokines and, very
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15ff9657540c02a53b23deefb27d3586
https://doi.org/10.1007/978-3-662-60309-3_2
https://doi.org/10.1007/978-3-662-60309-3_2
Autor:
Byung Won Yoo, Byung Hak Jin, J. M. Park, Min Soo Park, Jun Yeon Lee, Jae Soo Shin, Jung Hye Kim
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety