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Autor:
Rodolfo González-Segovia, Birmania Heredia-Rivera, Alfonso Claros-Guzmán, Martín Gerardo Rodríguez
Publikováno v:
Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
Many relevant aspects of mammal’s cardiac physiology have been mainly investigated in insect models such as Drosophila melanogaster and Periplaneta americana. Cardiac function has been poorly studied in the cockroach Gromphadorhina portentosa, whic
Autor:
Vincent M. Carroll, Daniel Holden, Seth C. Hopkins, Kenneth S. Koblan, Robert Lew, Richard E. Carson, Cristian Constantinescu, Gerald Galluppi
Publikováno v:
Psychopharmacology
Rationale Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains uncle
Autor:
Jeremy E. Melanson, Garnet McRae
Publikováno v:
Analytical and Bioanalytical Chemistry
The increase in production of cannabis for medical and recreational purposes in recent years has led to a corresponding increase in laboratories performing cannabinoid analysis of cannabis and hemp. We have developed and validated a quantitative liqu
Publikováno v:
Annals of Hematology
The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is approved for rela
Autor:
Tian-zi Wei, Xueqing Wu, Sheng-hui Guan, Chenle Dong, Yi Lu, Guanyu Wang, Hao Wang, Hai-ying Li, Feng-quan Dong, Yu-zhou Bao, Jian Zhang, Gu-li Zhu
Publikováno v:
Chinese Journal of Integrative Medicine
Objective To select potential molecules that can target viral spike proteins, which may potentially interrupt the interaction between the human angiotension-converting enzyme 2 (ACE2) receptor and viral spike protein by virtual screening. Methods The
Publikováno v:
Infection
Background Dermatomycoses are the most common fungal infections in the world affecting a significant part of the human and animal population. The majority of zoophilic infections in humans are caused by Trichophyton mentagrophytes. Currently, the fir
Autor:
K. Martin Kortüm, Katharina Meckel, Jun Song, Yu Jin, Xiaohua Hou, Tao Bai, Leo Rasche, Xiang Zhou, Hermann Einsele
Publikováno v:
Annals of Hematology
In total, we identified five Caucasian patients from Wurzburg (Nos. 1-5) and three Asian patients from Wuhan (Nos. 6-8). The majority of the patients were male (n = 5, 63%), and the median age at COVID-19 diagnosis was 57 (range 39-83 years). The thr
Autor:
Eiichiro Mori, Joachim Luginbühl, Sonia Sabate-Soler, Jens Christian Schwamborn, Silvia Bolognin, Alexander Skupin, Stefano Magni, Kaoru Kinugawa, Kamil Grzyb, Lisa M. Smits, Jay W. Shin
Publikováno v:
Cell and Tissue Research
Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organization and function of a respective organ or part of an organ. Human midbrain organoids (hMOs) have be
Publikováno v:
Chinese Journal of Integrative Medicine
Objective To study the protective mechanism of Chinese medicine Suxiao Jiuxin Pills (速效救心丸, SXJ) on myocardial ischemia and reperfusion (I/R) injury. Methods Mouse myocardial I/R injury model was created by 30-min coronary artery occlusion
Autor:
G. Tridente, Martin Raithel, Leonard B. Weinstock, H.-J. Hertfelder, Franz Ludwig Dumoulin, Jürgen Homann, G. J. Qagish, Gerhard J. Molderings, J. Textor, V. S. Schäfer, R. Barion, D. Klingmüller, Lawrence B. Afrin, B. Sido, D. Berdel, M. Mücke
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraind