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Autor:
Vincent M. Carroll, Daniel Holden, Seth C. Hopkins, Kenneth S. Koblan, Robert Lew, Richard E. Carson, Cristian Constantinescu, Gerald Galluppi
Publikováno v:
Psychopharmacology
Rationale Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains uncle
Autor:
Tian-zi Wei, Xueqing Wu, Sheng-hui Guan, Chenle Dong, Yi Lu, Guanyu Wang, Hao Wang, Hai-ying Li, Feng-quan Dong, Yu-zhou Bao, Jian Zhang, Gu-li Zhu
Publikováno v:
Chinese Journal of Integrative Medicine
Objective To select potential molecules that can target viral spike proteins, which may potentially interrupt the interaction between the human angiotension-converting enzyme 2 (ACE2) receptor and viral spike protein by virtual screening. Methods The
Publikováno v:
Chinese Journal of Integrative Medicine
Objective To study the protective mechanism of Chinese medicine Suxiao Jiuxin Pills (速效救心丸, SXJ) on myocardial ischemia and reperfusion (I/R) injury. Methods Mouse myocardial I/R injury model was created by 30-min coronary artery occlusion
Autor:
G. Tridente, Martin Raithel, Leonard B. Weinstock, H.-J. Hertfelder, Franz Ludwig Dumoulin, Jürgen Homann, G. J. Qagish, Gerhard J. Molderings, J. Textor, V. S. Schäfer, R. Barion, D. Klingmüller, Lawrence B. Afrin, B. Sido, D. Berdel, M. Mücke
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
Omalizumab is an effective therapeutic humanized murine IgE antibody in many cases of primary systemic mast cell activation disease (MCAD). The present study should enable the clinician to recognize when treatment of MCAD with omalizumab is contraind
Autor:
Jason T. Lee, András Füredi, Oliver Langer, R. Michael van Dam, Divya Maheshwari, Theresa Falls, Pavitra Kannan, Gergely Szakács, Severin Mairinger, Sabina Dizdarevic, Jeffrey Collins, Thomas Wanek
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher
Publikováno v:
AMB Express
AMB Express, Vol 11, Iss 1, Pp 1-11 (2021)
AMB Express, Vol 11, Iss 1, Pp 1-11 (2021)
The present study aimed at isolation of endophytic basidiomycetous fungi and evaluation of their in-vitro and in-vivo antidiabetic potential. Preliminary screening for in-vitro activity was carried out using α-glucosidase inhibition assay. An endoph
Autor:
Susan M. Abdel-Rahman, Jonathan B. Wagner, Kayode Ogungbenro, Aleksandra Galetin, J. Steven Leeder
Publikováno v:
European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-y, https://doi.org/10.1007/s00228-019-02697-y
Purpose Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic mo
Publikováno v:
Pflugers Archiv
Prostacyclin, or PGI2, is a product of PGI synthase (PGIS), down-stream of cyclooxygenase pathway. PGI2 has been demonstrated to play an important role in maintaining renal blood flow. Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclo
Autor:
Byung Won Yoo, Byung Hak Jin, J. M. Park, Min Soo Park, Jun Yeon Lee, Jae Soo Shin, Jung Hye Kim
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety
Publikováno v:
European Journal of Clinical Pharmacology
Background and objectives N-acetyltransferase 2 (NAT2) metabolize several drugs including isoniazid. We investigated the effect of genotype, geographical difference, and smoking habit on NAT2 phenotype in Ethiopians. Methods Genotyping for NAT2 191G