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Publikováno v:
Pflugers Archiv
Prostacyclin, or PGI2, is a product of PGI synthase (PGIS), down-stream of cyclooxygenase pathway. PGI2 has been demonstrated to play an important role in maintaining renal blood flow. Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclo
Publikováno v:
Recent Results in Cancer Research ISBN: 9783642303302
This chapter briefly summarizes the current knowledge about the role of nonsteroidal anti-inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase (COX)-2 (coxibs), on colorectal cancer (CRC) onset, and progression. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e746715352e048d7ec941965cffc276
https://doi.org/10.1007/978-3-642-30331-9_4
https://doi.org/10.1007/978-3-642-30331-9_4
Autor:
Bonny Blackard, Michael J. Thun
Publikováno v:
Cancer Prevention II ISBN: 9783540692966
This paper briefly reviews the pharma-cologic effects of nonsteroidal antiinflammatory drugs (NSAIDs) that influence the risks and benefits of using these drugs prophylactically for cancer. It describes the metabolism of arachidonic acid through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9f66b6613e8bf39e38b660fafac535
https://doi.org/10.1007/978-3-540-69297-3_20
https://doi.org/10.1007/978-3-540-69297-3_20
Autor:
V. Ralevic
Publikováno v:
Purinergic and Pyrimidinergic Signalling II ISBN: 9783540678489
Purine nucleotides and nucleosides were shown in 1929 to have potent effects on the heart and vasculature, in the first indication that these agents can act as extracellular signalling molecules in the cardiovascular system (Drury and Szent-Gyorgi 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc4a611d2a4b42fc7a3f6452f08be06
https://doi.org/10.1007/978-3-642-56921-0_4
https://doi.org/10.1007/978-3-642-56921-0_4
Autor:
Karl Heinz Rahn, Gerd Bönner
Publikováno v:
Prostacyclin and Hypertension ISBN: 9783540521402
The structural elucidation of prostacyclin (PGI2) showed that this substance is to be regarded as a typical cyclooxygenase product of the eicosanoids. The chemical structure of prostacyclin (Fig. 2) is described as 9-deoxo-6,9α-epoxy-delta5-PGF1α [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cdae07d3d2a9d13d4774879bd98894
https://doi.org/10.1007/978-3-642-95608-9_2
https://doi.org/10.1007/978-3-642-95608-9_2
Autor:
H. Ruppin
Publikováno v:
Prostaglandins and Leukotrienes in Gastrointestinal Diseases ISBN: 9783540187448
Endogenous prostaglandin E2 (PGE2) and prostacyclin produced by the gastric mucosa are thought to protect the stomach against the necrotizing effects of various damaging agents including gastric acid and pepsin [1]. Although gastric mucosal protectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744204b44c869efd25edf193ff46dd52
https://doi.org/10.1007/978-3-642-73316-1_43
https://doi.org/10.1007/978-3-642-73316-1_43
Autor:
Fritz Reinhard Matthias
Publikováno v:
Blood Coagulation Disorders ISBN: 9783540178132
Proprietary names: Aspirin, Colfarit, Godamed, Monobeltin. The acetyl-group of acetylsalicylic acid is transferred to a series of plasma proteins (albumin, globulin, hemoglobulin, platelet proteins). The functional limitation of the thrombocytes depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566bdf933ad1f2c3ab487b8df82c79a7
https://doi.org/10.1007/978-3-642-83098-3_14
https://doi.org/10.1007/978-3-642-83098-3_14
Autor:
R. Paoletti
Publikováno v:
Prostaglandin E1 in Atherosclerosis ISBN: 9783540172406
Prostaglandin E1 (PGE1) was discovered by Bergstrom’s group in the 1960s and the structure was originally defined (Fig. 1). PGE1 is a component of the prostaglandin (PG) group and is called a stable prostaglandin; it can be much more active in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3437fc0f407e4713b9ffcc796a943e63
https://doi.org/10.1007/978-3-642-71679-9_1
https://doi.org/10.1007/978-3-642-71679-9_1