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Publikováno v:
Chinese Journal of Integrative Medicine
Objective To study the protective mechanism of Chinese medicine Suxiao Jiuxin Pills (速效救心丸, SXJ) on myocardial ischemia and reperfusion (I/R) injury. Methods Mouse myocardial I/R injury model was created by 30-min coronary artery occlusion
Autor:
Jason T. Lee, András Füredi, Oliver Langer, R. Michael van Dam, Divya Maheshwari, Theresa Falls, Pavitra Kannan, Gergely Szakács, Severin Mairinger, Sabina Dizdarevic, Jeffrey Collins, Thomas Wanek
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher
Autor:
Franziska Hartung, Luis A. Pardo
Publikováno v:
European Biophysics Journal
Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strategy using Kv10.1 as a target. Kv10.1 is a
Autor:
Gerd A. Kullak-Ublick, Christoph Gubler, Katharina Spanaus, Alexander Jetter, Manfred G. Ismair, Tatiana Claro da Silva
Publikováno v:
European Journal of Clinical Pharmacology
Eur J Clin Pharmacol
Eur J Clin Pharmacol
Purpose In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein expression of the transporter OAT
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Background Doxorubicin treatment is known to cause muscular weakness. However, the cellular mechanisms have not been elucidated. We aimed to determine the effects of acute doxorubicin treatment on proteome lysine acetylation status, an indication of
Publikováno v:
Botanical Studies
Background We reported that yam dioscorin and its peptic hydrolysates exhibited ACE inhibition and antihypertensive effects on SHRs, however, the active peptides are not really isolated until now. Using ACE inhibitory screenings, two penta-peptides,
Autor:
Vino Daniel
Publikováno v:
Drug Discovery and Evaluation: Pharmacological Assays ISBN: 9783642277283
Drug Discovery and Evaluation: Pharmacological Assays ISBN: 9783319053912
Drug Discovery and Evaluation: Pharmacological Assays ISBN: 9783319053912
The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5983f69430a6bb85835ce413ac93ba54
https://doi.org/10.1007/978-3-642-27728-3_41-1
https://doi.org/10.1007/978-3-642-27728-3_41-1
Publikováno v:
Advances in Intelligent and Soft Computing ISBN: 9783642275364
This paper carries on anti-tumor activities research of the ethanol extract of Magnolia officinalis (MEE). Our results showed that MEE has obvious anti-tumor activities to transplanted tumor model of the mouse S180 sarcoma in vivo. The inhibitory rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae4769f78b1ab4535921cbf2fa18d225
https://doi.org/10.1007/978-3-642-27537-1_67
https://doi.org/10.1007/978-3-642-27537-1_67
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642145407
Intestinal P-glycoprotein (P-gp, ABCB1) may significantly influence drug absorption and elimination. Its expression and function is highly variable, regio-selective and influenced by genetic polymorphisms, drug interactions and intestinal diseases. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b7b958875113e152ebce51f7945a36
https://doi.org/10.1007/978-3-642-14541-4_11
https://doi.org/10.1007/978-3-642-14541-4_11
Publikováno v:
IFMBE Proceedings ISBN: 9783642038990
Wound healing is a collaborative process involving a variety of cellular and matrix components which need to interact continually towards a common goal. Growth factors and cytokines are two distinct categories of signaling proteins that modulate woun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977c2189cbd72902b7c98cbc80d30ff0
https://doi.org/10.1007/978-3-642-03900-3_49
https://doi.org/10.1007/978-3-642-03900-3_49